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Freestyle Valve Experience: Technical Considerations and Mid-term Results (1998)

Sintek, Colleen F. ; Pfeffer, Thomas A. ; Kochamba, Gary S. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Journal of cardiac surgery 13 (1998), S. 0

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ISSN: 1540-8191

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract Background: Many studies have demonstrated the superior hernodynamics of stentless porcine aortic valves compared to stented valves. This article describes the operative techniques and reviews our 5-year experience with the Medtronic Freestyle stentless valve. Methods: Between January 1993 and November 1997, 95 patients underwent implantation of the Medtronic Freestyle valve at a mean age of 76 years. All patients were seen at 6 months, 1 year, and annually thereafter for clinical assessment and Doppler echocardiography. Results: There were three operative and ten late deaths (two cardiac and eight noncardiac). Three strokes and four transient ischemic attacks occurred in the follow-up period. Four patients had bacteremia that was treated successfully with antibiotics. No patient required reoperation for valve-related problems. Serial echocardiograms revealed a decrease in mean systolic gradients across the valve during the first year and an increase in effective orifice areas. Ninety-one percent of patients had no, or trace, aortic insufficiency at the time of discharge and this has not increased over time. Conclusion: The Medtronic Freestyle valve has excellent hemodynamics and good clinical results. In our experience, no patient has required reoperation in a 5-year follow-up.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1540-8191.1998.tb01098.x

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γδ-Mediated deletions of chromosomal segments on F-prime plasmids (1983)

Deonier, Richard C. ; Yun, Kwok ; Kuppermann, Miriam

Springer

Molecular genetics and genomics 190 (1983), S. 42-50

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ISSN: 1617-4623

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary Deleted derivatives of F lac + proC + tsx +/− purE + plasmids ORF203 and F13 were isolated and physically characterized. Among 31 deletions, 24 were adjacent to the γδ element on F, four were associated with IS2 or IS3 elements normally present on F, and three displayed additional DNA rearrangements. With the genetic selection employed, the deletion endpoints in the chromosomal segment could fall anywhere within a 210 kb (5 min) region between proC and lac. The distribution of endpoints in this region was not random: the endpoints primarily occurred in an extended region near purE, and a 50 kb segment between tsx and purE was devoid of deletion endpoints. Deletion termini for mutants obtained from F13, which contains an additional 48 kb-segment interposed between γδ and the target region on ORF203, displayed a distribution similar to that seen for ORF203. Among simple deletions, there was no marked tendency for the chromosomal deletion endpoints to fall at IS1, IS3, or IS5 elements normally present in this chromosomal region. Point mutations and mutations caused by γδ or IS transposition into lac appeared in a small proportion of all plasmids studied.