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  • 1
    Electronic Resource
    Electronic Resource
    Extracellular ATP Causes Changes in Plasma Membrane Permeability of Mouse Lymphocytes (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 603 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb37691.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    LACK OF T-CELL MEDIATED CYTOTOXICITY IN M-MSV SYSTEM DEPENDING ON H-2 HAPLOTYPES (1979)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 6 (1979), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The H-2 restriction phenomenon was evaluated with regard to the immune response to Moloney sarcoma virus (M-MSV)-induced tumours in the mouse. Using an in vitro51Cr release assay the lytic activity of lymphocytes from M-MSV immune strains of mice, including several H-2 recombinant strains, was determined on leukaemic cell lines originally induced in mice of different strains by neconatal infection with Moloney leukaemia virus. In analogy with other experimental models, it was observed that a compatibility between effector and target cells at the K and/or D regions is generally necessary and sufficient to obtain the cytotoxic effect. However, for the H-2d and H-2b haplotypes, identity at the K or D region respectively was not sufficient for lysis to occur. Attempts to demonstrate that this lack of activity might be associated with the absence of H-2-linked Ir responder genes, were not successful.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1979.tb00689.x
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  • 3
    Electronic Resource
    Electronic Resource
    Antitumour efficacy of lymphokine-activated killer cells loaded with ricin against experimentally induced lung metastases (1992)
    Springer
    Cancer immunology immunotherapy 35 (1992), S. 27-32 
    Details
    ISSN: 1432-0851
    Keywords: LAK cells ; Ricin ; Lung metastases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adoptive transfer of tumour-specific T lymphocytes loaded with ricin into tumour-bearing mice exerts a transient therapeutic effect against locally induced tumours [Cerundolo et al. (1987) Br J Cancer 55: 413]. As transferred cells preferentially locate in the lung, we studied the therapeutic effect of ricin-loaded, lymphokine-activated killer (LAK) cells on lung metastases induced by M4 or B16-F1 (F1) tumour cell injection. In vitro studies demonstrated that ricin-treated LAK cells were about 100-fold more efficient than untreated LAK cells in inhibiting growth of the ricin-sensitive M4 tumour cell line. This effect was most likely due to the released ricin, as treated and untreated LAK cells inhibited the relatively toxin-resistant F1 cell line to the same extent. Ricin treatment did not alter the tissue distribution of intravenously (i.v.) injected LAK cells, which selectively localized in the lung early after inoculation, whether or not metastases were present. Adoptive transfer experiments showed that ricintreated LAK cells were significantly more efficient than untreated LAK cells in inhibiting M4- but not F1-induced lung metastases. These results indicate that LAK cells are able to deliver a therapeutic concentration of antineoplastic compounds directly to the lung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01741051
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  • 4
    Electronic Resource
    Electronic Resource
    Leukemia-cell rejection due to T-region encoded antigens (1981)
    Springer
    Immunogenetics 12 (1981), S. 433-443 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The role of H-2- and T-region products in determining allogeneic cell rejection was evaluated inH-2 congenic and recombinant mice by transplanting A1ATH and A6ATL leukemia cell lines induced in A.TH and A.TL strains, respectively, by Moloney murine leukemia virus. — InK- orD-region incompatible hosts transplant failure was observed, while inI +T-region incompatible hosts either rejection or prolonged survival was seen. In mice preimmunized with spleen cells fromI- and/orT-region incompatible donors, leukemia cells were rejected by mice immune only to T-region products, and accepted by mice immune only to I-region products. — Cell-mediated cytotoxicity studies confirmed in vivo results. Secondary CTLs specifically directed against I-region products did not lyse the A1ATH and A6ATL cells, and secondary CTLs from A.TH and A.TL mice sensitized against A6ATL and A1ATH cells respectively exerted a lytic action specific for T-region products, while no activity was observed against I determinants. — The data suggest that tumor-transplant rejection may also be governed by histocompatibility antigens encoded in theT region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01561686
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    Paper (German National Licenses)
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