ISSN:
0170-2041
Keywords:
Phytochelatins
;
Isopeptide bond
;
Gluthatione
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Phytochelatins which are linear peptide polymers of the γ-glutamylcysteine portion of glutathione with the general formula H-[γ-Glu-Cys]n-Gly-OH (n = 2-11) are the main components for the detoxification of heavy metals in the plant kingdom. So far these peptides have been mostly obtained by isolation from cell suspension cultures. We have now prepared some of these (n = 2-4) by the classical solution synthesis under mild conditions. For the protection of amino, carboxyl and thiol functions Nps, tBu and StBu protecting groups have been employed, respectively. The characterization of the peptide intermediates and final products has been achieved by mass spectrometry, 13C-NMR spectroscopy and amino acid analysis.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199219920157
Permalink