ISSN:
1573-4927
Keywords:
human diamine oxidase
;
variant genes
;
polymorphism
;
copper amine oxidase
;
amiloride-binding protein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Genes for two forms of human placenta diamine oxidase(dao) were cloned from a cDNA library and sequenced. One gene,pdao 1, is identical in length to human kidneydao but differs from it by two bases in the coding region and differs slightly in the 3′- and 5′-noncoding regions. The second gene,pdao2, is nearly identical to these genes in the coding region, except that it has an extra 57-nucleotide coding segment near the 3′ end of this region. This segment corresponds to the contiguous sequence of the 3′ end of intron 3 of human kidneydao. pdao2 also differs significantly frompdao1 and human kidneydao in a 13-base sequence in the 5′-noncoding region. It is proposed thatpdao1 and human kidneydao are polymorphic forms of the same allele. Whetherpdao2 is a polymorph of these two is not certain, because of the significant differences in the coding and noncoding regions.Pdao2 may represent a different allele.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00553624
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