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  • 1
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 6966-6974 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A theoretical analysis has been carried out to compare the resonance condition in the asymmetric double-barrier structure with that in the symmetric triple-barrier one. It is found that the triple-barrier structure may be considered as two quasidouble-barrier structures whose resonance condition may decide the resonance levels in the triple-barrier structure. It is confirmed that two modes exist in the triple-barrier structure: one is normal mode consisting of doublet and the other is degenerated mode of singlet. The critical condition between the two modes is given and its physical meaning is examined. Moreover, it is confirmed that both the normal mode and the degenerated mode exist also in symmetric n-fold barrier structures (n≥3). © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary In the past 20 years, more than 20 cases of a type of granulomatous disease have been noticed by dermatologists in different areas of China. The patients had these features in common: (i) the lesions followed a slight trauma to the face; (ii) they were spreading dark-red plaques without pus or ulceration; (iii) new lesions appeared near to or far from the original lesion; (iv) histopathology showed histiocytic granuloma; (v) the patients had severe headache and clouding of consciousness during the later stages of the disease; (vi) all patients died within 1·5–4 years; (vii) treatment with prednisone led to some healing of the lesions but accelerated death; and (viii) all patients were from rural areas. We examined the tissues from two similar patients by electron microscopy and identified two kinds of bacteria as a possible cause of the disease. One was an anaerobic actinomycete, the other was Staphylococcus capitis. The anaerobic actinomycete was sensitive to lincomycin (a forerunner of clindamycin). After a 5-month therapy with lincomycin, one patient survived. We infer that the cause of death is the unknown anaerobic actinomycete. Because the disease is very severe, we suggest the name ‘fatal bacteria granuloma after trauma’ to draw attention.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Antikeratin (AK) autoantibodies, circulating antibodies against epidermal keratins, have been detected in all normal human sera. However, direct evidence on the biological significance of AK autoantibodies is still lacking. Objectives To purify AK autoantibodies from human serum and to make a preliminary study of their biological effects on human keratinocytes. Methods We first extracted keratin polypeptides from human stratum corneum and analysed their purity using sodium dodecyl sulphate–polyacrylamide gel electrophoresis (SDS–PAGE). Next, a keratin affinity column was prepared with the extracted keratins, and AK autoantibodies were purified from pooled normal human serum. Antibodies obtained were identified with SDS–PAGE, enzyme-linked immunosorbent assay, immunoperoxidase staining, immunoelectron microscopy and Western blotting. The biological effect of AK autoantibodies on cultured human keratinocytes was studied using a DNA synthesis assay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric determination and cell cycle analysis. Results On average, 1·83 ± 0·24 mg of antibodies could be purified from 10 mL of pooled human serum. High-titre IgG (about 1 : 70) and low-titre IgM (about 1 : 30) AK autoantibodies were obtained. The DNA synthesis assay and MTT colorimetric determination demonstrated that AK autoantibodies have a significant dose-dependent inhibitory effect on cultured keratinocytes. Correlation coefficients in the two experiments were − 0·583 and − 0·797, respectively. Cell cycle analysis indicated that a small dose of AK autoantibodies leads to inhibition of proliferation of cultured keratinocytes, whereas a large dose of AK autoantibodies causes a visible hypodiploid peak, suggesting apoptosis of keratinocytes. Conclusions The present research lays a solid foundation for further investigation into the biological significance of natural AK autoantibodies.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0630
    Keywords: 73.20.Dx ; 13.40. DK
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Analytical expressions for the transmission coefficient and the resonance condition in unsymmetrical rectangular double-barrier structures are derived theoretically by taking into account the mass difference between well and barrier layers. It is found that resonant tunneling with a transmission peak equal to 1 (unity resonance) and resonant tunneling with a transmission peak less than 1 (below unity resonance) may occur in the unsymmetrical double-barrier structures. Two independent conditions are required for unity-resonant transmission: One is the Phase-Difference Condition for Resonance (PDCR) and the other is the Maximum Condition for the Peak Value (MCPV). The below-unity resonant transmission occurs when only condition PDCR holds. It is believed that the two conditions are useful for calculating values of the transmission coefficient and the resonance energy for the unsymmetrical double-barrier structures. They may be useful for resonant tunneling-device fabrication. Furthermore, wave functions of an electron at resonance level are calculated and the confining phenomenon is confirmed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0630
    Keywords: PACS: 73.20.Dx; 13.40. DK
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract.  Analytical expressions for the transmission coefficient and the resonance condition in unsymmetrical rectangular double-barrier structures are derived theoretically by taking into account the mass difference between well and barrier layers. It is found that resonant tunneling with a transmission peak equal to 1 (unity resonance) and resonant tunneling with a transmission peak less than 1 (below unity resonance) may occur in the unsymmetrical double-barrier structures. Two independent conditions are required for unity-resonant transmission: One is the Phase-Difference Condition for Resonance (PDCR) and the other is the Maximum Condition for the Peak Value (MCPV). The below-unity resonant transmission occurs when only condition PDCR holds. It is believed that the two conditions are useful for calculating values of the transmission coefficient and the resonance energy for the unsymmetrical double-barrier structures. They may be useful for resonant tunneling-device fabrication. Furthermore, wave functions of an electron at resonance level are calculated and the confining phenomenon is confirmed.
    Type of Medium: Electronic Resource
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