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  • 1
    Electronic Resource
    Electronic Resource
    Flavonoids as superoxide scavengers and antioxidants
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 9 (1990), S. 19-21 
    Details
    ISSN: 0891-5849
    Keywords: Antioxidation ; Flavonoid ; Free radicals ; Scavenger ; Superoxide
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0891-5849(90)90045-K
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lipid peroxidation and antioxidative defense systems in early leaf growth (1991)
    Springer
    Journal of plant growth regulation 10 (1991), S. 187-189 
    Details
    ISSN: 1435-8107
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Changes in lipid peroxidation activities—superoxide dismutase (SOD), peroxidase (POD), and antioxidation—have been studied in leaves ofCucumis sativus during early growth until full expansion in situ. The content of malonyldialdehyde (MDA) rapidly decreased and then increased gradually. The changes in SOD, POD, and antioxidation activities were similar to each other and inverse to the changes in MDA contents. In the first phase, decrease in MDA is accompanied by increase in the activities of antioxidative defense systems, and in the second, exponential growth phase, increase in MDA content is accompanied by the decrease in defense systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279332
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Role of superoxide anion on the proliferation and c-Ha-ras or p53 expression in prostate cancer cell line PC3 (1998)
    Springer
    Urological research 26 (1998), S. 349-353 
    Details
    ISSN: 1434-0879
    Keywords: Key words Superoxide anion ; Proliferation ; Gene expression ; p53 ; c-Ha-ras ; Prostate cancer cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to investigate the role of superoxide anion (O−. 2) in the regulation of p53 or c-Ha-ras expression and proliferation in the prostate cancer cell line PC3. Cell proliferation was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in the presence of O−. 2, basic fibroblast growth factor (bFGF) or their combination. p53 or C-Ha-ras expression in the cells treated with O−. 2 was assayed by fluorescence in situ hybridization (FISH). The proliferation was significantly inhibited by O−. 2 in a concentration-dependent manner ranging from 9 to 36 μmol/l nicotinamide adenine dinucleotid (NADH) combined with 2–8 μmol/l N-methylphenazonium methyl sulfate (PMS). Enhancement of proliferation by 2 ng/ml bFGF was significantly inhibited by O−. 2. Although O−. 2 was not able to alter c-Ha-ras gene expression, O−. 2 at the concentrations of 18 μmol/l NADH and 4 μmol/l PMS upregulated the expression of p53. O−. 2 may modulate proliferation and gene expression in PC3 cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002400050068
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  • 4
    Electronic Resource
    Electronic Resource
    Hydrogen peroxide-induced apoptosis in human hepatoma cells is mediated by CD95(APO-1/Fas) receptor/ligand system and may involve activation of wild-type p53 (2000)
    Springer
    Molecular biology reports 27 (2000), S. 1-11 
    Details
    ISSN: 1573-4978
    Keywords: apoptosis ; CD95 ; human hepatoma cell ; hydrogen peroxide ; p53
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Reactive oxygen species (ROS) play an important role in cell death induced by many different stimuli. Direct exposure of human hepatoma cell line SMMC-7221 to hydrogen peroxide (H2O2) can induce apoptosis characterized by morphological evidence and fragmentation of DNA assayed by terminal deoxynucleotidyl transferase assay (TUNEL assay). Analysis of flow cytometry indicated that H2O2 can decrease the level of CD95(APO-1/Fas), and it is confirmed that H2O2 can also activate the differential expression of some specific gene such as p53 by means of RT-PCR technique. The results indicated that CD95 signal transduction system may be involved in the H2O2-induced apoptosis, and can regulate some specific genes associated with apoptosis in transcription and translation levels such as p53.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007003229171
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    Paper (German National Licenses)
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