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  • 1
    Electronic Resource
    Electronic Resource
    Liquid chromatographic determination of 6-thiopurine metabolites formed in vitro in electrochemical and enzymatic oxidative activation
    Amsterdam : Elsevier
    Analytica Chimica Acta 237 (1990), S. 305-310 
    Details
    ISSN: 0003-2670
    Keywords: Electrochemical activation ; Enzymatic activation ; Oxidation ; Thiopurine
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0003-2670(00)83933-1
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Functional consequences of acute collagen degradation studied in crystalloid perfused rat hearts (1997)
    Springer
    Basic research in cardiology 92 (1997), S. 147-158 
    Details
    ISSN: 1435-1803
    Keywords: Key words Rat – collagen – developed pressure – pressure – volume relationships – extracellular matrix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: The impact of acute collagen disruption by the disulfide donor, 5,5'-dithio-2-nitrobenzoic acid (DTNB) on ventricular properties was tested in rat hearts. Methods: Collagen was degraded acutely in 13 isolated, isovolumically contracting rat hearts by perfusion with 1 mM DTNB added to Krebs-Henseleit solution for 1 hour followed by 2-hour perfusion with normal solution. Another with normal solution for 3 hours (Control). Results: Collagen content was 3.5 ± 0.5 % of ventricular dry weight in control group compared with 2.1 ± 0.4 % in DTNB group (decrease by 40%, p 〈 0.01). Scanning electron micrographs revealed loss of the delicate collagen network surrounding muscle fibers in DTNB treated hearts. Developed pressure at a fixed volume decreased to 86 ± 17 % of the baseline value after 3-hour perfusion in the control group, whereas in DTNB treated hearts developed pressure fell to 68 ± 13 % (p 〈 0.01). End-diastolic pressure was set at 5 mmHg at the beginning of the experiment and rose to 15 ± 8 mmHg in control and 30 ± 13 mmHg (p 〈 0.01) in the treated hearts. Concomitantly, wetto-dry weight ratio increased from 5.63 ± 0.26 in control to 6.07 ± 0.11 (p 〈 0.05) in the DTNB treated hearts. A separate set of experiments on isolated myocytes excluded the possibility of a direct effect of DTNB on myocyte contractile function. Conclusions: These data suggested that with 40% collagen disruption by DTNB there is a significant increase in tissue edema that results in a decrease in chamber capacitance; in addition, there is a significant decrease in systolic performance which reflects the combined effect of edema and loss of collagen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003950050033
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Blood flow capacity via direct acute myocardial revascularization (1997)
    Springer
    Basic research in cardiology 92 (1997), S. 45-51 
    Details
    ISSN: 1435-1803
    Keywords: Dog ; Vineberg procedure ; coronary artery disease ; coronary bypass surgery ; myocardial ischemia ; transmyocardial laser revascularization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The concept of direct myocardial revascularization, achieving myocardial perfusion through means other than the normal coronary vasculature, has a long history with the most widely investigated technique being the Vineberg procedure; current interest centers around the encouraging preliminary clinical results obtained with transmyocardial laser revascularization. Despite significant previous research, the acute blood flow potential through the direct myocardial route remains unknown. Nontransmural laser channels were made in the distal LAD territory from the epicardial surface of 5 mongrel dogs to which an internal mammary artery was connected. A flow probe was placed on the distal most portion of the artery and an intercostal branch was cannulated for infusion of colored microspheres. Measurements were taken under baselin conditions and following LAD and epicardial collateral ligation. Under all conditions, blood flow pattern was of a to-and-fronature. At baseline, there was an average 0.60±0.24 ml/min net flow into the myocardium which was all contained within 0.5 cm of the central channel with a final myocardial perfusion of 0.011±0.016 ml/min/g. Following induction of ischemia average flow increased to 1.41±0.51 ml/min which extended as far as 1 cm from the channel with a final myocardial perfusion of 0.22±0.19 ml/min/g. In conclusion, a limited amount of acute myocardial perfusion can be achieved by the present technique of direct myocardial revascularization and the amount of flow is highly dependent upon the amount of flow through the native circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00803756
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Blood flow capacity via direct acute myocardial revascularization (1997)
    Springer
    Basic research in cardiology 92 (1997), S. 45-51 
    Details
    ISSN: 1435-1803
    Keywords: Key words Dog – Vineberg procedure – coronary artery disease – coronary bypass surgery – myocardial ischemia – transmyocardial laser – revascularization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The concept of direct myocardial revascularization, achieving myocardial perfusion through means other than the normal coronary vasculature, has a long history with the most widely investigated technique being the Vineberg procedure; current interest centers around the encouraging preliminary clinical results obtained with transmyocardial laser revascularization. Despite significant previous research, the acute blood flow potential through the direct myocardial route remains unknown. Nontransmural laser channels were made in the distal LAD territory from the epicardial surface of 5 mongrel dogs to which an internal mammary artery was connected. A flow probe was placed on the distal most portion of the artery and an intercostal branch was cannulated for infusion of colored microspheres. Measurements were taken under baseline conditions and following LAD and epicardial collateral ligation. Under all conditions, blood flow pattern was of a to-and-fro nature. At baseline, there was an average 0.60 ± 0.24 ml/min net flow into the myocardium which was all contained within 0.5 cm of the central channel with a final myocardial perfusion of 0.011 ± 0.016 ml/min/g. Following induction of ischemia average flow increased to 1.41 ± 0.51 ml/min which extended as far as 1 cm from the channel with a final myocardial perfusion of 0.22 ± 0.19 ml/min/g. In conclusion, a limited amount of acute myocardial perfusion can be achieved by the present technique of direct myocardial revascularization and the amount of flow is highly dependent upon the amount of flow through the native circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00803756
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Functional consequences of acute collagen degradation studied in crystalloid perfused rat hearts (1997)
    Springer
    Basic research in cardiology 92 (1997), S. 147-158 
    Details
    ISSN: 1435-1803
    Keywords: Rat ; collagen ; developed pressure ; pressure-volume relationships ; extracellular matrix
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: The impact of acute collagen disruption by the disulfide donor, 5,5′-dithio-2-nitrobenzoic acid (DTNB) on ventricular properties was tested in rat hearts.Methods: Collagen was degraded acutely in 13 isolated, isovlumically contracting rat hearts by perfusion with 1 mM DTNB added to Krebs-Henseleit solution for 1 hour followed by 2-hour perfusion with normal solution. Another 13 hearts were perfused with normal solution for 3 hours (Control).Results: Collagen content was 3.5±0.5% of ventricular dry weight in control group compared with 2.1±0.4% in DTNB group (decrease by 40%, p〈0.01). Scanning electron micrographs revealed loss of the delicate collagen network surrounding muscle fibers in DTNB treated hearts. Developed pressure at a fixed volume decreased to 86±17% of the baseline value after 3-hour perfusion in the control group, whereas in DTNB treated hearts developed pressure fell to 68±13% (p〈0.01). End-diastolic pressure was set at 5 mmHg at the beginning of the experiment and rose to 15±8 mmHg in control and 30±13 mmHg (p〈0.01) in the treated hearts. Concomitantly, wet-to-dry weight ratio increased from 5.63±0.26 in control to 6.07±0.11 (p〈0.05) in the DTNB treated hearts. A separate set of experiments on isolated myocytes excluded the possibility of a direct effect of DTNB on myocyte contractile function.Conclusions: These data suggested that with 40% collagen disruption by DTNB there is a significant increase in tissue edema that results in a decrease in chamber capacitance; in addition, there is a significant decrease in systolic performance which reflects the combined effect of edema and loss of collagen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00788632
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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