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  • 1
    ISSN: 1619-7089
    Keywords: Radionuclides ; Coronary vessels ; Heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Retrospective analyses of the stress thallium studies of 51 patients with a history of previous infarctions or definite stable angina were performed in order to determine the extent of the coronary-artery disease (CAD). The results were correlated with recent coronary-angiography findings in order to assess the effect of including rightventricule (RV) visualization on the accuracy of the detection of right coronary-artery (RCA) disease, as well as the effect of graded stenosis or occlusion of the RCA and the presence of disease of the other coronary vessels on the visualization of the RV. Eight patients had normal coronary arteries. The other 43 patients had CAD, only 5 of whom had single-vessel RCA disease. With regard to the RV, 6 patients had nonvisualization, 30 had patchy visualization, and 15 had normal visualization in the stress thallium studies. Nonvisualization indicated 100% occlusion of RCA in 6 out of 6 patients. Patchy visualization indicated significant occlusion of the RCA in 25 out of 30 patients (83%), while normal visualization indicated a normal RCA in 13 out of 15 patients (86%). Normal visualization did not mean that the possibility of RCA disease could be excluded. When RV visualization data were added to LV images, the sensitivity for detecting RCA increased from 66% to 94% (P〈0.05), the specificity decreased from 89% to 72% (P〈0.1), and the predictive accuracy increased from 75% to 86% (P〉0.1).
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1619-7089
    Keywords: Heart disease ; Radionuclides ; MUGA study ; Pulmonary hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pulmonary hypertension (PH) produces strain followed by hypertrophy and later dilatation of the right ventricle (RV) and pulmonary artery. The signs and symptoms are nonspecific. There is a need for a noninvasive sensitive way to diagnose PH. The purpose of this study is to evaluate phase abnormalities in radionuclide MUGA studies of patients with referred diagnosis of PH. In a retrospective analysis of 44 patients who had a radionuclide multigated study (MUGA) and contrast ventriculography (CV), 19 had high mean pulmonary pressure (over 20 mmHg) and a high pulmonary vascular resistance index (over 2.0). In 15 patients, a delayed phase segment in the RV corresponding to the pulmonary infundibulum and pulmonary conus was noted “The Pulmonary Tongue” sign (PT), 12 had PH (True positive) and 3 did not (false positive) on CV. No PT was seen in the remaining 29 patients, only 7 of them had PH (False negative). The sensitivity, specificity and accuracy of the PT sign in detecting PH was 80%, 72% and 77% respectively. The number of patients was too small to calculate the correlation of the grade of PT with the severity of PH. We conclude that “The Pulmonary Tongue” sign on a MUGA study is clinically useful in detecting PH.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1619-7089
    Keywords: Cardiac function ; Analysis ; Dual gated tomography ; Contrast ventriculography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A dual gated tomography (DGT) program for end systolic and end diastolic acquisition and subsequent processing for calculation of LVEF, end diastolic and end systolic volumes (EDV, ESV) has been evaluated in 20 healthy volunteers (25 years–40 years) and 45 patients (25 years–60 years): 20 with ischaemic heart disease and 25 with valvular heart disease (VHD). All had biplane multigated blood pool (MUGA) studies in the 40° LAO projection using in vivo 99mTc- RBCs, immediately followed by DGT. The results in the patients group were correlated with contrast ventriculography (CV). In the volunteer group, the normal values for LVEF, EDV and ESV measured with DGT were found to be 63%±10%, 91 ml±6 ml and 30 ml±6 ml and r value for the LVEF=0.91 compared with MUGA. In the IHD group, r values compared with CV were 0.915 and 0.97 for the EDV and ESV and 0.934 for the LVEF. Compared with the MUGA, the r value for LVEF was 0.883. In the VHD group, r values were 0.98 for both the EDV and ESV and 0.948 for the LVEF (P〈0.002) compared with CV and 0.789 for the LVEF compared with the MUGA. We feel that DGT is an accurate and reproducible technique for LV function measurements.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 13 (1988), S. 527-529 
    ISSN: 1619-7089
    Keywords: 201Tl ; Tumour imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Following the intravenous injection of 75 MBq 201Tl-chloride we have assessed the uptake kinetics in the myocardium and in the primary tumour in 56 patients with lung cancer, 26 with breast cancer and 13 with mediastinal lymphoma. The time of maximal tumour uptake ranged from 8–20 min post-injection and did not differ significantly between lung cancer (mean±SD=11.9±3.34 min), breast cancer (11.21±1.88 min) and lymphoma (11.76±3.25 min). The time of maximum cardiac uptake of 201Tl was 11.61±3.25 min. There was no significant washout of 201Tl from the tumours in the first hour after injection in the various malignant lesions studied. The time of maximal tumour to background activity was 18.3±0.59 min for lung cancer, 13.0±1.16 min for breast cancer and 16.7±1.04 min for lymphoma. The time course of 201Tl uptake in the tumours suggests that the mechanism of uptake is similar to that in the myocardium. The optimal time of 201Tl tumour imaging is from 20–60 min following injection and did not differ in various tumours studied.
    Type of Medium: Electronic Resource
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