Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Die Elektrophysiologie der Atmung (1997)
    Springer
    Der Nervenarzt 68 (1997), S. 945-955 
    Details
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Atemmuskelinsuffizienz ; Elektrophysiologie der Atmung ; Diagnostik ; Key words Neurological respiratory insufficiency ; Electrophysiological diagnosis methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Neurological respiratory insufficiency may be the primary cause of admission to an intensive care unit or may develop during care in an intensive care ward. Severe respiratory insufficiency due to nervous system causes either involves a lack of central drive or weakness of the respiration muscles. The former are induced by a wide variety of encephalopathies and the latter by diseases of anterior horn cells, peripheral nerve, the neuromuscular junction, or muscles of the chest wall or diaphragm. In an intensive care unit, it is often not possible clinically to determine whether there is a lack of central drive or a neuromuscular problem. It is now possible by electrophysiological methods to pinpoint the site of nervous system cause of respiratory insufficiency. This review will describe the various electrophysiological techniques currently available and describe how they have been successfully applied in investigating some conditions that cause severe respiratory failure.
    Notes: Zusammenfassung Die neurologisch bedingte Atemmuskelinsuffizienz kann sowohl Ursache zur Aufnahme an der Intensivstation sein als auch sekundär im Rahmen der Intensivtherapie auftreten. Das Spektrum neurologisch bedingter Atemstörungen umfaßt eine Vielzahl von Erkrankungen des zentralen und peripheren Nervensystems. Die klinische Differenzierung der Genese neurologischer Atemstörungen ist insbesondere bei Patienten der Intensivstation häufig nicht möglich. Neu entwickelte elektrophysiologische Techniken erlauben eine präzise Lokalisationsdiagnostik der Atemstörung, welche für das Management dieser Patienten nützlich ist. In dieser Übersicht werden die elektrophysiologischen Untersuchungen zur Diagnostik der Atemmuskelfunktion und deren Einsatz bei neurologisch bedingten Atemstörungen vorgestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001150050221
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Vinorelbine-induced neurotoxicity in patients with advanced breast cancer pretreated with paclitaxel – a phase II study (1996)
    Springer
    Cancer chemotherapy and pharmacology 39 (1996), S. 150-156 
    Details
    ISSN: 1432-0843
    Keywords: Key words Neurotoxicity ; Vinorelbine ; Paclitaxel ; Breast cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Vinorelbine (VNB) shows high antitumoral activity in advanced breast cancer due to its high affinity for mitotic tubulin and differs from the other vinca alkaloids with regard to its low degree of neurotoxicity because of its low affinity for axonal tubulin. Preclinical data show the existence of different binding sites on tubulin for vinca alkaloids and paclitaxel (P), suggesting a lack of cross-resistance. Thus, VNB was chosen eligible for a phase II study to evaluate both the therapeutic efficacy and the toxicity of VNB in patients (pts) with advanced breast cancer failing first-or second-line chemotherapy with P. A total of 14 pts with advanced breast cancer pretreated with P were entered into the study. Therapy consisted of VNB at 30 mg/m2 diluted in 500 ml of normal saline given over 30 min after a minimal interval of 4 weeks since the last application of P. For the first four cycles, injections were repeated at 2-week intervals; thereafter they were repeated at 3-week intervals until evidence of progressive disease or severe toxicity developed. All but one pt was considered assessable for response and all pts were evaluable for toxicity. No objective response was observed; two pts showed no change in their disease. In four pts therapy had to be stopped because peripheral neurotoxicity increased from a pretherapeutic level after therapy with P from National Cancer Institute Common Toxicity Criteria (NCI-CTC) grade 1 (n=3) and 2 (n=1) to neurotoxicity grade 3 after 1, 2 (n=2), and 3 cycles of therapy with VNB, respectively. In addition, constipation of grade 2 occurred in 10 pts. Hematologic toxicity was negligible. No other evaluable toxicity exceeded NCI-CTC grade 1. Both observations of this study, the complete resistance to VNB and the increase in peripheral neuropathy, let us assume the existence of a preclinically not anticipated but clinically relevant cross-resistance between these two spindle poisons and the presence of common functional targets. Therefore, P-pretreated pts should be excluded from consecutive VNB-containing therapies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050551
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    High dose immunoglobulin therapy is effective in the Miller Fisher syndrome (1994)
    Springer
    Journal of neurology 241 (1994), S. 178-179 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00868348
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    MRI in patients with general paresis (1996)
    Springer
    Neuroradiology 38 (1996), S. 120-123 
    Details
    ISSN: 1432-1920
    Keywords: Key words Neurosyphilis ; General paresis ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Few cases of MRI in neurosyphilis have been reported. We examined the value of MRI in patients with general paresis; MRI was performed on four HIV-negative patients with parenchymatous neurosyphilis. It demonstrated frontal and temporal atrophy, subcortical gliosis and, in one patient, increased ferritin in the basal ganglia. The progression of the lesions on MRI correlated well with the neuropsychiatric disturbances. The MRI findings correlated with the well-known neuropathological findings. This combination of pathological findings in neurosyphilis has not been described before and we suggest that MRI is of prognostic value in patients with general paresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00604794
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    MRI in patients with general paresis (1996)
    Springer
    Neuroradiology 38 (1996), S. 120-123 
    Details
    ISSN: 1432-1920
    Keywords: Neurosyphilis ; General paresis ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Few cases of MRI in neurosyphilis have been reported. We examined the value of MRI in patients with general paresis; MRI was performed on four HIV-negative patients with parenchymatous neurosyphilis. It demonstrated frontal and temporal atrophy, subcortical gliosis and, in one patient, increased ferritin in the basal ganglia. The progression of the lesions on MRI correlated well with the neuropsychiatric disturbances. The MRI findings correlated with the wellknown neuropathological findings. This combination of pathological findings in neurosyphilis has not been described before and we suggest that MRI is of prognostic value in patients with general paresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00604794
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Brain mapping of median nerve somatosensory evoked potentials with combined99mTc-ECD single-photon emission tomography and magnetic resonance imaging (1996)
    Springer
    European journal of nuclear medicine 23 (1996), S. 579-582 
    Details
    ISSN: 1619-7089
    Keywords: Somatosensory cortex ; Brain mapping ; Electrically evoked potentials ; Single-photon emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Single-photon emission tomography (SPET) was performed during electrical median nerve stimulation and used to detect focal neuronal activation in the somatosensory pathways. Intravenously administered technetium-99m ethyl cysteinate dimer (ECD) was used as a blood flow tracer to obtain baseline and activated images in each of three subjects. After image registration, baseline images were compared voxel by voxel with the activation images. In addition, the mean summation of the activated-state images of the subjects was compared with the mean summation of the baseline-state images of ten normal subjects. Discrete brain regions occupying 0.9%–1.6% of total brain volume showed an increase in signal from 33.6% to 35.0%. For further anatomical localization of regional increases in signal, the MRI scan of each subject was registered and superimposed on the activated-state SPET image. This method may be used to localize lesions in various disorders of the central nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00833396
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...