ISSN:
1432-0428
Keywords:
Aldose reductase
;
animal models
;
cataracts
;
diabetes
;
red blood cells
;
sorbitol dehydrogenase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Screening for red blood cell sorbitol dehydrogenase deficiency in 12 different mammalian species was performed. A wide inter-species variability in red cell sorbitol dehydrogenase with a virtually complete deficiency in pigs was observed. Aldose reductase and sorbitol dehydrogenase activities in 12 different pig tissues also were measured. Aldose reductase activity was present in all the tissues studied, whereas organ specificity for sorbitol dehydrogenase was observed. Sorbitol dehydrogenase activity was not detectable in lenses, among other tissues, making the pig a potential model for studies in experimental diabetes, particularly for the investigation of sorbitol dehydrogenase deficiency as a risk factor in the development of cataracts.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00273916
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