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  • Articles: DFG German National Licenses  (21)
  • Inorganic Chemistry  (19)
  • Endothelial cells  (2)
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  • Articles: DFG German National Licenses  (21)
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  • 1
    Electronic Resource
    Electronic Resource
    Functional serotonin 5-HT1D receptors and 5-HT1Db receptor mRNA expression in human umbilical vein endothelial cells (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 580-582 
    Details
    ISSN: 1432-1912
    Keywords: Key words 5-Hydroxytryptamine (5-HT ; serotonin) ; 5-HT1D receptors ; 5-HT1Dβ receptors ; Endothelial cells ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pharmacological evidence has suggested the presence of 5-hydroxytryptamine (5-HT, serotonin), 5-HT1D receptors on endothelial cells but these receptors have never been identified unambiguously on this type of cells. We now report that human umbilical vein endothelial cells (HUVEC) express 5-HT1D receptors coupled to inhibition of cyclic AMP formation. 5-HT and the 5-HT1D receptor agonists 5-carboxamidotryptamine (5-CT) and sumatriptan were approximately equipotent at inhibiting forskolin-stimulated cyclic AMP accumulation in HUVEC (mean pEC50 7.6–8.2, maximal effect 30% inhibition). The 5-HT1A receptor agonist, 8-OH-DPAT was clearly less potent (pEC50 6.2) and less efficacious. The selective 5-HT1D receptor antagonist, GR127935 (1 nM) markedly inhibited the effect of 5-HT (apparent pKB 10.8). Reverse transcription-polymerase chain reaction analysis showed the mRNA for 5-HT1Dβ receptors to be expressed in HUVEC. These results demonstrate the presence of functional 5-HT1D receptors and the expression of 5-HT1Dβ receptor mRNA in HUVEC. They support the involvement of 5-HT1Dβ receptors in endothelial-mediated responses to 5-HT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169394
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Functional serotonin 5-HT1D receptors and 5-HT1Dβ receptor mRNA expression in human umbilical vein endothelial cells (1995)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 580-582 
    Details
    ISSN: 1432-1912
    Keywords: 5-Hydroxytryptamine (5-HT, serotonin) ; 5-HT1D receptors ; 5-HT1Dβ receptors ; Endothelial cells ; Cyclic AMP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pharmacological evidence has suggested the presence of 5-hydroxytryptamine (5-HT, serotonin), 5-HT1D receptors on endothelial cells but these receptors have never been identified unamiguously on this type of cells. We now report that human umbilical vein endothelial cells (HUVEC) express 5-HT1D receptors coupled to inhibitiion of cyclic AMP formatin. 5-HT and the 5-HT1D receptor agaonists 5-carboxamidotryptamine (5-CT) and sumatriptan were approximately equipotent at inhibiting forskolin-stimulated cyclic AMP accumulation in HUVEC (mean pEC50 7.6–8.2, maximal effect 30% inhibition). The 5-HT1A receptor agonist, 8-OH-DPAT was clearly less potent (pEC50 6.2) and less efficacious. The selective 5-HT1D receptor antagonist, GR127935 (1 nM) markedly inhibited the effct pf 5-HT (apparent pKB 10.8). Reverse transcription-polymerase chain reaction analysis showed the mRNA for 5-HT1Dβ receptors to be expressed in HUVEC. These results demonstrate the presence of functional 5-HT1D receptors and the expression of 5-HT1Dβreceptor mRNA in HUVEC. They support he involvement of 5-HT1Dβ receptors in endothelial-mediated responses to 5-HT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169394
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Zur Darstellung und Kristallstruktur von CrSO4 · 3 H2O (1990)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 586 (1990), S. 141-148 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation and Crystal Structure of CrSO4 · 3 H2OEvaporating a solution of Cr2+ in dilute sulphuric acid at 70°C light blue crystals of CrSO4 · 3 H2O were grown. Its x-ray powder diffraction pattern is quite similar to that of CuSO4 · 3 H2O. The crystal structure refinement of CrSO4 · 3 H2O (space group Ce, a = 5.7056(8) Å, b = 13.211(2) Å, c = 7.485(1) Å, β = 96.73(1)°, Z = 4) from single crystal data, using the parameters of the copper compound as starting values, results in a final R-value of R = 3.8%.The surrounding of the Cr2+ ion can be described as a strongly elongated octahedron. The basal plane of the CrO6-octahedron consists of three hydrate oxygen atoms and one sulphate oxygen atom. The two more distant axial oxygen atoms also belong to sulphate groups. Thus they are forming chains of alterning CrO6-octahedra and SO4-tetrahedra along [110] and [1-10] linked via common corners. These chains are connected via sulphate groups and by bridging hydrogen bonds to a 3-dimensional network.
    Notes: Durch Kristallisieren aus einer schwefelsauren Lösung von Chrom(II)-Sulfat (T ≈ 70°C) ist das hellblaue Trihydrat CrSO4 · 3 H2O erhältlich. Die Verbindung ist isotyp zu CuSO4 · 3 H2O. Die Strukturverfeinerung anhand von Einkristalldaten erfolgte in der Raumgruppe Cc mit a = 5,7056(8) Å, b = 13,211(2) Å, c = 7,485(1) Å, β = 96,73(1)°, Z = 4 und konvergierte bei R = 3,8%.Cr2+ ist verzerrt oktaedrisch koordiniert. Die Basisfläche des Oktaeders wird von drei Hydratsauerstoffatomen und einem Sulfatsauerstoffatom aufgespannt. Zwei weitere Sauerstoffatome von Sulfatgruppen vervollständigen in einem größeren Abstand die elongierten Oktaeder. Diese sind untereinander über gemeinsame Sulfatpolyeder verknüpft. Dadurch ergeben sich Ketten, in denen CrO6-Oktaeder und SO4-Tetraeder abwechseln. Diese Ketten, deren Orientierung jeweils [110] und [1-10] in c-Richtung wechselt, sind über Sulfatgruppen und Wasserstoffbrückenbindungen miteinander verbunden.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19905860119
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  • 4
    Electronic Resource
    Electronic Resource
    Zur Darstellung und Kristallstruktur von CrSO4 · 3 H2O (1990)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 580 (1990), S. 224-224 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19905800127
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  • 5
    Electronic Resource
    Electronic Resource
    Zum Mechanismus des 36Cl- und 82Br- Isotopenaustausches von [Co en2 X2]+ -Komplexen (1967)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 349 (1967), S. 158-163 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The isotopic exchange of Cl- with trans-[Co(en)2, Cl2*]+ and of Br- with trans-[Co(en), Br2*]+ in acid methanolic solutions and its dependence upon temperature (30 bis 60°C ), complex salt-, halide- and acid concentration have been investigated. For trans-[Co(en)2Cl2*]+ in 0.51 N methanolic HCl a reaction velocity k1 (40°C) = 0.53 · 10-3 min-1 and an activation energy EA = 24 kcals./mole have been found, for trans-[Co(en), Br2*]+ in 0.25 N methanolic HBr k1 (40°C) = 3.9 · 10-3 min-1 and EA = 20.0 kcals./mole. From the experimental results the intermediate occurrence of a metastable solvate complex is concluded. The formation of ion pairs at increasing halide ion concentration accelerates the reaction.
    Notes: Der Isotopenaustausch von trans-[Co(en)2, Cl2*]+ mit Cl--Ionen und von trans-[Co(en)2Br2*]+ mit Br--Ionen wurde in sauren, methanolischen Lösungen in Abhängigkeit von der Temperatur (30-60°C), der Komplexsalz-, der Wasserstoffionen- und der Halogenionenkonzentration untersucht (1). Für trans-[Co(en)2, Cl2*]+ wurde in 0,51 n methanolischer HCl k1 (40°C) = 0,53 · 10-3 min-1 und eine Aktivierungsenergie EA von 24 kcal/Mol gefunden, für trans-[Co(en)2, Br2*]+ in 0,25 n methanolischer HBr k1 (40°C) = 3,9 · 10-3 · min-1 und EA = 20,0 kcal/Mol. Es wird auf das Vorliegen eines metastabilen Solvatkomplexes als Übergangszustand geschlossen. Die Bildung von Ionenpaaren mit steigender Halogenionenkonzentration beschleunigt die Reaktion.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19673490307
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  • 6
    Electronic Resource
    Electronic Resource
    Neue Beobachtungen zum chemischen Transport von GeO2 IV. Temperaturabhängigkeit mit dem Transportmittel Wasserstoff (1983)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 502 (1983), S. 89-101 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Novel Observations on the Chemical Transport of GeO2. IV. Temperature Dependence with the Transport Agent HydrogenThe chemical transport of GeO2 with H2 proceeds on the basis of reaction (1) \documentclass{article}\pagestyle{empty}\begin{document}$$ \begin{array}{*{20}c} {{\rm GeO}_{2,{\rm S}} + {\rm H}_2 = 1/{\rm n}({\rm GeO})_{{\rm n},{\rm g}} + {\rm H}_2 {\rm O}_{\rm g} {\rm with}\, {\rm n} = 1,2,3} & {(1)} \\ \end{array} $$\end{document}In the case of a filling pressure of 1 atm H2 a micro crystalline coating of GeO2(hex.) is obtained at T1, using a temperature gradient T2 — T1 = 100 K. In addition acicular, colourless crystals are growing. The shape depends on the mean transport temperatures T̄.Besides GeO2 a small amount of Ge is obtained at temperatures T̄ 〈 1023 K in the colder region of the ampoules. This additional Ge-Transport is not to be expected under equilibrium conditions. Model calculations show, that it is due to a kinetic inhibition of the deposition of GeO2. In a wide range of temperature the experimentally determined rates of transport are in accordance with the expected values.
    Notes: Der chemische Transport von GeO2 mit H2 nach Gl. (1) führt bei konstantem H2-Anfangsdruck (P°(H2) = 1 atm) im Temperaturgradienten T2 — T1 = 100 K zur Abscheidung eines feinkristallinen, farblosen Belages aus GeO2(hex.) bei T1, auf dem in Abhängigkeit von der mittleren Transporttemperatur T̄ nadelförmige Kristalle aufgewachsen sind.\documentclass{article}\pagestyle{empty}\begin{document}$$ \begin{array}{*{20}c} {{\rm GeO}_{2,{\rm S}} + {\rm H}_2 = 1/{\rm n}({\rm GeO})_{{\rm n},{\rm g}} + {\rm H}_2 {\rm O}_{\rm g} {\rm mit}\, {\rm n} = 1,2,3} & {(1)} \\ \end{array} $$\end{document}Zusätzlich tritt bei T̄ 〈 1023 K am weniger heißen Ende der Ampulle eine geringe Abscheidung von Ge auf, die unter Gleichgewichtsverhältnissen nicht zu erwarten wäre. Wie Modellrechnungen zeigen, kann der zusätzliche Ge-Transport auf eine kinetische Hemmung der Abscheidung von GeO2 zurückgeführt werden.Die experimentell bestimmten Transportraten sind in einem weiten Temperaturbereich in guter Übereinstimmung mit den Ergebnissen der Modellrechnungen.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19835020713
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  • 7
    Electronic Resource
    Electronic Resource
    Vorbericht (1985)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 521 (1985), S. 240-240 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19855210229
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  • 8
    Electronic Resource
    Electronic Resource
    Neue Beobachtungen zum chemischen Transport von GeO2. VI. Temperaturabhängigkeit mit dem Transportmittel Chlor (1985)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 528 (1985), S. 69-90 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: New Observations on the Chemical Transport of GeO2. VI. Temperature Dependence with the Transport Agent ChlorineIn a temperature gradient T2 - T1 = 100 K the chemical transport of tetragonal GeO2 is kinetically controlled at an average transport temperature T ≤ 1080 K. The same is true for the metastable hexagonal modification at T ≤ 1150 K. An Arrhenius equation describes the rate of deposition in a satisfactory way. The activation energy amounts to 21 kcal/Mol. At higher temperatures diffusion determines the rate of transport whereby GeCl4, Cl2, and O2 are looked upon as prominent gaseous molecules and the formation of a solid solution of hexagonal GeO2 with SiO2 is taken into account.For a transport temperature T 〈 1100 K GeO2 is deposited at T1 only if seeds of the specific modification are present. The deposition of GeO2(hex.) ceases at temperatures lower than T ≈ 1000 K. The formation of GeO2(tetr.) requires not only seeds but also NaCl as mineralizer and the temperature should not be lower than T ≈ 900 K.
    Notes: Im Temperaturgradienten T2 - T1 = 100 K ist die Abscheidung von tetragonalem GeO2 bei mittleren Transporttemperaturen T ≤ 1080 K kinetisch kontrolliert; für die (metastabile) hexagonale Modifikation trifft dies bei T ≤ 1150 K ebenfalls zu. In beiden Fällen ist nach Arrhenius für den geschwindigkeitsbestimmenden Schritt der Abscheidung die Aktivierungsenergie 21 kcal/Mol. Bei höheren Temperaturen entsprechen die Transportraten erwartungsgemäß einem diffusionskontrollierten Modell, wenn GeCl4, Cl2 und O2 als maßgebliche gasförmige Teilchen sowie eine Mischkristallbildung von hexagonalem GeO2 mit SiO2 in Betracht gezogen werden.Bei Experimenten mit T 〈 1100 K ließ sich GeO2 bei T1 nur in Gegenwart von Keimkristallen der jeweiligen Modifikation abscheiden. Die untere Grenze der Entstehung von GeO2(hex.) wurde dabei mit T ≈ 1000 K beobachtet. Zur Bildung von GeO2(tetr.) ist außer Keimkristallen auch NaCl als Mineralisator erforderlich; die untere Grenze lag bei T ≈ 900 K.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19855280908
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  • 9
    Electronic Resource
    Electronic Resource
    Neue Beobachtungen zum chemischen Transport von GeO2. III. Transportraten mit dem Transportmittel Wasserstoff (1981)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 475 (1981), S. 271-271 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19814750429
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  • 10
    Electronic Resource
    Electronic Resource
    Neue Beobachtungen zum chemischen Transport von GeO2. III. Transportraten mit dem Transportmittel Wasserstoff (1981)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 478 (1981), S. 111-118 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Novel Observations on the Chemical Transport of GeO2. III. Rates of Transport with HydrogenIn the course of a chemical transport in the system GeO2/H2 the composition of the solid phases can change until a steady state is reached. In this case an iterative calculation of the equilibrium is now possible. The method takes into acount the mutual interaction of the processes in the source and in the zone of deposition and allows a general application.The participation of H2 implies a large difference in the coefficients of diffusion which demands the estimation of the interaction of diffusion and laminar flow. The comparision of experimentally determined rates of transport with calculated values shows now that the increasing laminar flow is antagonistic to the deposition of GeO2.
    Notes: Transportbeobachtungen im System GeO2/H2, bei denen sich die Bodenkörperzusammensetzung mit dem Übergang vom Anfangszustand in den stationären Zustand änderte, lassen sich jetzt auf iterativem Wege rechnerisch erfassen. Das Verfahren, das auf der Grundlage einer exakten Massenbilanz die gegenseitige Beeinflussung der Vorgänge im Quellenraum und im Abscheidungsraum berücksichtigt, ist allgemein anwendbar. Die Beteiligung von H2 und die dadurch bedingte große Differenz der Diffusionskoeffizienten machte eine Abschätzung der Wechselwirkung zwischen Diffusion und Strömung erforderlich. Wie ein Vergleich experimenteller und berechneter Transportraten bestätigt, wirkt eine zunehmende Strömung der Abscheidung von GeO2 entgegen.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19814780713
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