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  • Artikel: DFG Deutsche Nationallizenzen  (4)
  • breast cancer  (2)
  • ion solvation  (2)
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  • Artikel: DFG Deutsche Nationallizenzen  (4)
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  • 1
    Digitale Medien
    Digitale Medien
    Conductance of 1:1 electrolytes in methyl formate (1987)
    Springer
    Journal of solution chemistry 16 (1987), S. 225-235 
    Details
    ISSN: 1572-8927
    Schlagwort(e): Conductivities ; 1:1 electrolytes ; methyl formate ; ion pairs ; triple ions ; ion solvation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The electrolytic conductivities of LiClO4, LiAlCl4, LiAsF6, NaClO4, NaBPh4, and Bu4NClO4 have been measured in methyl formate at 25°C. Evidence is presented for strong association between the perchlorate ion and the formyl proton of the solvent. Ion association and triple ion formation constants suggest that LiClO4, LiAlCl4, and NaClO4 form solvent separate ion pairs and triple ions. NaBPh4 forms contact ion pairs and triple ions, and the remaining salts appear to form both types of ion pairs and triple ions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00646988
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  • 2
    Digitale Medien
    Digitale Medien
    Conductance of 1∶1 electrolytes in methyl acetate (1989)
    Springer
    Journal of solution chemistry 18 (1989), S. 977-991 
    Details
    ISSN: 1572-8927
    Schlagwort(e): Conductivity ; 1∶1 electrolytes ; methyl acetate ; ion pairs ; triple ions ; ion solvation ; activity coefficients
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract The electrolytic conductances of NaClO4, NaB(C6H5)4, (n-C4H9)4NClO4 and (n-C4H9)4NPF6 have been measured in methyl acetate at 25°C. A dominating feature of these electrolyte solutions is, as expected, strong ion pairing. In addition it is found that the formation of triple ions makes an important contribution to the overall molar conductivities. The data suggest that there are strong ion-solvent interactions leading to structure-enhanced (after Diamond) ion association and triple ion formation which has an exact analogy in the phenomena of salting-in. The effects of increasing solution permittivity and viscosity are discussed, particularly in regard to comparing two models of treating conductivity data. The first model includes ion pairs and triple ions, and the second model ignores triple ion formation ascribing the anomalous increase in molar conductivities to a decrease in the ion association equilibrium constant caused by increasing solution permittivity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00647897
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  • 3
    Digitale Medien
    Digitale Medien
    Pharmacokinetic/pharmacodynamic interactions of intensive cyclophosphamide, cisplatin, and BCNU in patients with breast cancer (1993)
    Springer
    Breast cancer research and treatment 26 (1993), S. S11 
    Details
    ISSN: 1573-7217
    Schlagwort(e): autologous hematopoietic cell support ; BCNU ; breast cancer ; carboplatin ; cisplatin ; cyclophosphamide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Combinations of alkylating agents in intensive doses with autologous hematopoietic cell support (AHCS) are commonly used to treat advanced, solid tumors. Relatively little is known about the pharmacokinetic or pharmacodynamic aspects of their use. The cyclophosphamide, cisplatin, and BCNU (CPA/cDDP/BCNU) regimen is often used in patients with breast cancer. In these individuals, the blood levels of BCNU vary by more than tenfold. In rats given BCNU, the blood level variability is associated with cisplatin pretreatment, and mean levels are much higher than those that occur when cisplatin pretreatment is omitted. These observations suggest that a major elimination pathway for BCNU is metabolic and is subject to cisplatin disruption. Between 30–50% of patients receiving the CPA/cDDP/BCNU regimen experience a steroid-responsive pulmonary injury that can be fatal if untreated. Blood levels of BCNU are positively correlated with the risk of pulmonary injury in these patients. Others have demonstrated that blood levels of CPA can be inversely correlated with the likelihood of cardiac toxicity and 2-year, relapse-free survival in patients with breast cancer. Emerging data suggest that circulating drug levels, rather than the calculated dose, best explain the variability of outcome in patients treated with combination alkylating agents and AHCS.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00668355
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  • 4
    Digitale Medien
    Digitale Medien
    New strategies in marrow purging for breast cancer patients receiving high-dose chemotherapy with autologous bone marrow transplantation (1993)
    Springer
    Breast cancer research and treatment 26 (1993), S. S19 
    Details
    ISSN: 1573-7217
    Schlagwort(e): amifostine ; autologous bone marrow transplantation (ABMT) ; breast cancer ; 4-hydroperoxycyclophoshamide (4-HC) ; marrow purging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary High-dose chemotherapy and autologous bone marrow transplantation (ABMT) are commonly used to treat selected patients with high-risk breast cancer. A limitation of ABMT is that clonogenic cancer cells could be collected with the bone marrow and produce a relapse of disease when reinfused into patients. Purging the marrowex vivo may eliminate the tumor cells, but it can also delay engraftment. We employed two different purging methods whereby breast cancer cells were depleted without delaying engraftment. The addition of WR-2721 (amifostine) to 4-hydroperoxycyclophosphamide (4-HC) reduced the time to engraftment by 10 days compared with marrow purged with 4-HC alone (26 versus 37 days, respectively). The positive selection of CD34+ hematopoietic progenitors produced engraftment within 21 days. The use of granulocyte colony-stimulating factor (G-CSF) accelerated the engraftment time of CD34+ hematopoietic progenitors to 11 days.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00668356
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