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  • Articles: DFG German National Licenses  (13)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 12 (1985), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The allotypic markers of immunoglobulin heavy chains (Gm, Am and Em allotypes) provide important contributions to the differentiation between populations, and they are informative for tracing racial origin, migration and admixture of isolates and stray groups. The combined Glm; G2m; G3m; A2m; Em haplotypes are a highly polymorphic system that is a powerful tool in population genetics because of the existence of haplotypes that are unique for a particular race. In this paper, data on Gypsies living in Hungary are compared with those obtained in other populations, in particular Hindus and non-Hindus from India. The analysis agrees with anthropological and philological evidence for population movements from Asia to Europe.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 5 (1978), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 4 (1977), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: An analysis of the HLA data of 100 myasthenia gravis (MG) patients and their first degree relatives and spouses is presented. The family studies confirmed the excess of B8 in the myasthenia gravis patients and showed that the excess was not limited to the A1, B8 haplotype. An excess of B8 homozygous patients was found from the matings of two B8 heterozygous parents, suggesting the existence of a dominant B8 linked MG susceptibility. B8 homozygous individuals run a 4.7 times higher risk of acquiring myasthenia gravis than B8 heterozygous individuals.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Of 118 Dutch patients suffering from ankylosing spondylitis (AS) 81.4% were found to be positive for the HLA antigen B27. The B27 frequency proved to be significantly higher in patients in whom the disease had an early onset.In addition to B27, another HLA antigen may be associated with AS; the antigen Bw16 was found to be significantly increased in B27 negative AS patients.HLA phenotype frequencies were also determined in 109 patients with idiopathic inflammatory bowel disease (IBD). In fifty-eight ulcerative colitis (UC) patients a raised incidence of A11 was noticed. In fifty-one patients with Crohn's disease (CD) the antigen B18 showed an increased frequency. Both deviations were statistically significant. In thirty-nine patients suffering from both AS and IBD 50% proved to be B27 positive, which is significantly different from the B27 frequency in patients with AS alone. In the B27 negative patients with AS and IBD an increased frequency of Bw16 was also shown.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 274 (1976), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 207 (1965), S. 327-328 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Family K. with D-D translocation, studied in the University Laboratory of Genetics in Nijmegen, provided the following information: both parents are heterozygous, Hp 2-1; two out of their seven children are chromosomally normal, Hp 2-2; two are carriers of the translocation, Hp 1-1; three are ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 204 (1964), S. 792-793 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The first observations of the Xga testing in this family were: mother, brother and sister of the patient positive, father and patient very weakly positive or negative. Repeating the tests with the red cell suspensions of father and patient resulted again in doubtful reactions, even when a double ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 89 (1982), S. 1-20 
    ISSN: 1437-1596
    Keywords: Paternity index, paternity cases ; Blood group expertise, paternity index ; Paternitätsindex, Vaterschafts-Fälle ; Blutgruppengutachten, Vaterschaftsindex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung In einer früheren Arbeit erwähnte der Autor einige Aspekte zum Vaterschafts-Index I (=X/Y): Unter falschen Terzetten ist die Frequenz derjenigen mit gleichem oder höherem I als ein (beobachteter) I-Wert von I x beträchtlich niedriger als 1/I x; unter falschen Terzetten ist der Mittelwert von I gleich 1 und unter nicht-ausgeschlossenen Nicht-Vätern ist er gleich der Umkehr einer Möglichkeit des Nicht-Ausschlusses; unter richtigen Terzetten ist der Mittelwert von 1/I (=i) gleich der Möglichkeit des Nicht-Ausschlusses von Nicht-Vätern. In einem statistischen Material werden sehr starke Abweichungen von einigen dieser Erwartungen beobachtet. In der vorliegenden Arbeit werden weitere Charakteristika der Verteilung von I-Werten berücksichtigt, besonders aber jene, die gelten sollten, wenn ln I in eine Normalverteilung passen soll. Es wurde angenommen, daß mit Hilfe einer solchen Verteilung die oben erwähnten Abweichungen als eine Variabilitätsmöglichkeit erkannt werden können. Es scheint jedoch, daß weder die Logarithmen des Paternitätsindex, noch jene des Zygotie-Index von Zwillingen (ausgesucht als ein analoges Modell, das leichter zu analysieren ist als der Paternitäts-Index) tatsächlich normal verteilt sind. Dies wiederum macht die Bestimmung der Vaterschaftswahrscheinlichkeit, die sich auf solche Annahmen stützt, zweifelhaft. Darüber hinaus wird festgestellt, daß auch aus anderen Gründen andere Schätzungen als Essen-Möllers W (oder I oder i) als wichtigste Irrtumswahrscheinlichkeit in der Praxis zu Annahmen führen, die in ähnlicher Weise a priori-Voraussetzungen wie W-Werte unterworfen sind und tatsächlich häufiger zu Irrtümern führen können als jene. Besondere Aufmerksamkeit wird der statistischen Analyse der Paternitätsstudien mit mehr als einem Putativvater gewidmet, woraus geschlossen wird, daß in solchen Fällen die Formel, die als gleichrangig mit Essen-Möllers Formel für Ein-Mann-Paternitätsfälle erachtet wird, nämlich W=X/(X+Y) oder I/(I+1), wie folgt lauten muß: W 1=I 1/(ΣI+n); W 2=I 2/(ΣI+n) etc. und nicht: W 1=I 1/(ΣI+1); W 2=I 2/(ΣI+1) etc.
    Notes: Summary In a previous paper the author mentioned some aspects of the paternity index I (=X/Y): Among false triplets the frequency of those with I equal to or higher than an (observed) I value of I x is considerably lower than 1/I x; among false triplets the mean value of I is equal to 1, and among non-excluded non-fathers it is equal to the inverse of the chance of non-exclusion; among true triplets the mean value of 1/I (=i) is equal to the chance of non-exclusion of non-fathers. In a statistical material rather strong deviations from some of these expectations were observed. In the present paper further characteristics of the distribution of I values were taken into consideration, and especially those that should hold if lnI would fit in with a normal distribution. It was supposed that with the aid of such a distribution the deviations mentioned above could be recognized as chance variability. It appears, however, that neither the logarithms of the paternity index, nor those of the zygosity index of twins (chosen as an analogous model that is more easily analysable than the paternity index) are really normally distributed. This, in turn, makes that estimates of probability of paternity, based on such a supposition, are of doubtful reliability. Besides it is concluded that also for other reasons other estimates than Essen-Möller's W (or I or i), as probability of first type errors, lead in practice to conclusions that are equally subdue to a priori suppositions as are W values and may be, in fact, much more erroneous than those. Special attention is paid to the statistical analysis of paternity studies with more than one alleged father, and it is concluded that in such cases the general formula that may be considered to be equivalent with Essen-Möller's formula for one-man paternity cases, i.e., W=X/(X+Y) or I/(I+1), must be W 1=I 1/(ΣI+n); W 2=I 2/(ΣI+n) etc. and certainly not W 1=I 1/(ΣI+1); W 2=I 2/(ΣI+1) etc.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A genetic linkage study was performed in a large Dutch kindred with erythrokeratodermia variabilis (EKV, McKusick no. 13320). The autosomal-dominant trait appeared to segregate rather consistently with the cde (r) gene complex of the Rh system. Only one recombinant was found amongst 27 informative individuals. Lod score calculations gave strong evidence for close linkage between the loci for EKV and Rh (with a maximum lod score of 5.55 at a recombination fraction of 0.044).
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 38 (1977), S. 175-182 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A statistical method has been developed which can be used to distinguish between various possible explanations for the associations that have been observed between HLA and certain diseases. By analyzing the numbers of B27 positives with and without a second detectable B locus antigen in patients with ankylosing spondylitis and in a control series, three possible hypotheses have been tested: 1. the B27 antigen itself makes an individual more susceptible; 2. a recessive susceptibility gene is closely linked with HLA; 3. a dominant susceptibility gene is closely linked with HLA. In four groups of patients suffering from another disease the procedure has also been applied and it turns out that at least in some of these the second hypothesis can be rejected while the third seems to be the most likely.
    Type of Medium: Electronic Resource
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