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Digitale Medien

New classes ofStreptomyces coelicolor A3(2) mutants blocked in undecylprodigiosin (Red) biosynthesis (1991)

Coco, E. A. ; Narva, K. E. ; Feitelson, J. S.

Springer

Molecular genetics and genomics 227 (1991), S. 28-32

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Details

ISSN: 1617-4623

Schlagwort(e): Recombinant DNA ; Antibiotic production ; Genetic organization ; Directed mutant screen ; Prodigiosin

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Summary Fifteen mutants ofStreptomyces coelicolor A3(2) blocked in both the bipyrrole branch (redA) and a second site specific to the undecylprodigiosin pathway were characterized. Some of the mutants were ordered biosynthetically based on cosynthesis experiments. Complementation of each of the mutants with wild-type DNA cloned in low- and high-copy number plasmid vectors allowed the mutants to be separated into 12 new classes which are physically clustered within approximately 37 kb on theS. coelicolor genome. Early-step biosynthetic genes are centrally located and are flanked by later-step and regulatory genes.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00260702

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