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  • Artikel: DFG Deutsche Nationallizenzen  (22)
  • Digitale Medien  (22)
  • Cell & Developmental Biology  (22)
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  • Artikel: DFG Deutsche Nationallizenzen  (22)
Materialart
  • Digitale Medien  (22)
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  • 1
    Digitale Medien
    Digitale Medien
    Assessment of sister chromatid exchange in mouse embryos produced by microsurgical fertilization (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 38 (1994), S. 142-147 
    Details
    ISSN: 1040-452X
    Schlagwort(e): Micromanipulation ; Zona pellucida ; DNA repair ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie
    Notizen: The treatment of male factor-related infertility has been approached with the advent of several methods for microsurgical fertilization, such as the partial dissection of the zona pellucida (PZD) and the injection of sperm into the perivitelline space (PVSI) of oocytes. These techniques are designed to increase sperm-oolemma interaction by circumventing passage of the sperm through the zona pellucida. The present study was performed to evaluate the influence of PZD and PVSI on the in vitro development of mouse embryos by assessing the rate of sister chromatid exchange (SCE). SCE is considered to be a sensitive indirect indicator of DNA lesions due to various conditions. Oocytes were cultured in vitro after PZD or PVSI and then examined for SCE. There was no significant difference in SCE between control and treatment groups of embryos and the values were similar to those reported by Saito et al. (Fertil Steril 41:460-464, 1984). The rate of SCE was low during the first two mitotic cycles, then increased from cycle two to three before declining slightly between the 3rd and 4th cycles of cell division. These data demonstrate that the direct interaction of sperm and oocyte by PZD or PVSI did not have an adverse effect on the development of mouse embryos as assessed by the rate of SCE. © 1994 Wiley-Liss, Inc.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrd.1080380204
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  • 2
    Digitale Medien
    Digitale Medien
    Local alteration of cortical actin in Xenopus eggs by the fertilizing sperm (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 35 (1993), S. 69-75 
    Details
    ISSN: 1040-452X
    Schlagwort(e): Amphibian ; Microfilaments ; Fertilization ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie
    Notizen: Rhodamine phalloidin (Rph) staining was used to examine the microfilament organization of the Xenopus laevis egg cortex during the early stages of fertilization. Unactivated eggs possessed a cytochalasin B (CR)-insensitive Rph-stained matrix that was reorganized upon egg activation and diminished in the presence of CB. Xenopus laevis sperm caused a temporary local increase in Rph staining on the Xenopus cortex. In CB-treated eggs, the local increases of cortical Rph staining later changed to a Rph-free area. These temporary local increases of cortical Rph staining were also observed when Notophthalmus viridescens sperm fertilized Xenopus and Rana pipiens eggs, and were followed by the appearance of concentric rings of stained and unstained areas. Our data suggest that Xenopus and Notophthalmus sperm have activities that can both organize and disrupt the cortical filamentous actin of the Xenopus egg. © 1993 Wiley-Liss, Inc.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrd.1080350112
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  • 3
    Digitale Medien
    Digitale Medien
    Thrombospondin-4 is expressed by early osteogenic tissues in the chick embryo (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Developmental Dynamics 203 (1995), S. 477-490 
    Details
    ISSN: 1058-8388
    Schlagwort(e): Thrombospondin ; Development ; Extracellular matrix ; In situ hybridization ; Chondrogenesis ; Osteogenesis ; Cornea ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The thrombospondins are a family of related glycoproteins found in the embryonic extracellular matrix. To date, five members of this family have been identified. Thrombospondin-1 and thrombospondin-2 have similar primary structure, but are expressed in different tissues at different times during development. Thrombospondins-3, -4, and cartilage oligomeric protein belong to a second thrombospondin subgroup in which the carboxyl-half of each molecule is most similar to thrombospondin-1 and -2. Here, we report the cloning and sequencing of a novel probe to avian thrombospondin-4. We have used this probe to determine the origins of thrombospondin-4 in the chick embryo by in situ hybridization. Thrombospondin-4 transcripts first appear in the mesenchyme surrounding bone anlage coinciding with the initial stages of osteogenesis. The expression in osteogenic tissues is transient: thrombospondin-4 mRNAs are not seen in the osteoblasts of bone collars in developing long bones. This pattern is distinct from avian thrombospondin-2, which is expressed in perichondrium and embryonic fibrous connective tissues. Our observations indicate that connective tissues are the principal site of thrombospondin-4 expression in the chick. The diverse origins of different thrombospondin gene family members imply distinctive roles for these proteins related to the growth and differentiation of cartilage, tendons, and bone. ©1995 Wiley-Liss, Inc.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aja.1002030410
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  • 4
    Digitale Medien
    Digitale Medien
    The vacuome of the flagellate Chlamydomonas (1931)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 51 (1931), S. 527-543 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: A vacuome (‘Golgi apparatus’) consisting of small globular inclusions has been demonstrated in Chlamydomonas sp. These inclusions may be seen in the living, unstained organism; they are stainable vitally with neutral red; they have been stained vitally with neutral red and then blackened with osmic vapor under direct observation, and they have been impregnated by osmic and silver methods without previous treatment with neutral red.The reaction of these inclusions to the iodin test for starch suggests that they may play some rǒle, possibly one of storage, in the cycle of starch metabolism.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1050510207
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  • 5
    Digitale Medien
    Digitale Medien
    Histology and histochemistry of the parotid and the principal and accessory submandibular glands of the little brown bat (1982)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 172 (1982), S. 271-285 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The parotid and the principal and accessory submandibular glands of the little brown bat, Myotis lucifugus (Vespertilionidae), were examined using light microscopy and staining methods for mucosubstances. The parotid gland is a compound tubuloacinar seromucous gland. Parotid gland secretory cells contain both neutral and nonsulfated acidic mucosubstances. The principal and accessory submandibular glands are compound tubuloacinar mucus-secreting glands. They contain somewhat atypical mucus-secreting demilunar cells that often appear to be interspersed between mucous tubule cells. The mucous tubule cells in both the principal and accessory submandibular glands contain sulfomucins. Demilunar cells of the principal submandibular gland contain moderate amounts of nonsulfated acidic mucosubstances, but the corresponding cells of the accessory submandibular gland contain considerable neutral mucosubstance with very little acid mucosubstance. Intercalated ducts composed of cuboidal or low columnar epithelial cells are present in all three glands. Striated ducts in all glands are composed of columnar cells whose apices bulge into the ductal lumina. Excretory ducts are composed of simple columnar epithelium, with occasional basal cells that suggest a possible pseudostratified nature. The cells of the excretory ducts also have bulging apices. All duct types contain apical cytoplasmic secretory material that is a periodic acid-Schiff positive, neutral mucosubstance. Ductal apical secretory material is more evident in intercalated and striated ducts than in excretory ducts.
    Zusätzliches Material: 25 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051720303
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  • 6
    Digitale Medien
    Digitale Medien
    Fertilization and aqueous development of the puerto rican terrestrial-breeding frog, Eleutherodactylus coqui (1987)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 193 (1987), S. 217-224 
    Details
    ISSN: 0362-2525
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The Puerto Rican tree frog, Eleutherodactylus coqui, has internal fertilization and direct development on land. In light of these reproductive adaptations, the events of fertilization and early development were studied. Cytological examination of just-fertilized eggs showed that sperm entry is restricted to about 10% of the surface of these large, yolky eggs, and all nuclear events of the first cell cycle occur near the animal pole. Although the oocytes have cortical granules, a number of polyspermic fertilizations were found. One clutch consisted of eggs with a high frequency of polyspermy and of normal development. This raises the possibility that normal development can occur despite multiple sperm entry, a situation not found in other anuran amphibians. With respect to saline requirements, the sperm and the embryo are similar to those in amphibians with external fertilization and aqueous development. Sperm motility was high in low-tonicity conditions, and the normally terrestrial embryo could develop completely from a fertilized egg to a froglet in a low-tonicity aqueous solution.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jmor.1051930208
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  • 7
    Digitale Medien
    Digitale Medien
    The hematological alterations resulting from repeated injections of 6-mercaptopurine into AKR miceThe 6-mercaptopurine was secured in the form of a crystalline hydrate through courtesy and generosity of Dr. George H. Hitchings of the Wellcome Research Laboratories, Tuckahoe, New York. (1958)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 132 (1958), S. 1-23 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Zusätzliches Material: 4 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1091320102
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  • 8
    Digitale Medien
    Digitale Medien
    Computer analysis of the human embryo growth curve: Differences between published ultrasound findings on living embryos in utero and data on fixed specimens (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 237 (1993), S. 400-407 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Human embryo ; Crown-rump length ; Greatest length ; Computer analysis ; Vaginal ultrasound ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Accurate information on the normal growth rate of the human embryo is fundamental to a better understanding of the embryonic period of pregnancy. Crown-rump length measured previously in utero (N = 227) with vaginal ultrasound in 107 in vitro fertilization (IVF) or gamete intrafallopian transfer (GIFT) singleton pregnancies was compared to the greatest length of fixed human embryos from the Carnegie collection, of known developmental stage whose postovulatory ages were estimated from menstrual histories. Average crown-rump length in utero was 60% of the greatest length of the fixed specimens prior to postovulation day 33, but were equal after postovulation day 40. The growth rate of in utero embryos and fixed specimens, analyzed by computer using exponential equations, was compared to linear and polynomial equations used in previously published embryo growth tables. The exponential equation, length = exp(a + b/age), fit in utero measurements best, while the equation length = exp[a + b/exp(age)] fit the fixed specimens best. Differences between length in utero and in fixed specimens may be related to distortion of the fixed embryos resulting from the formalin fixation, to ultrasound distortion, to curling of the embryo, or to incorrectly estimated ages of the fixed specimens. Study of human embryos in utero is now practical with vaginal ultrasound. © 1993 Wiley-Liss, Inc.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1092370313
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  • 9
    Digitale Medien
    Digitale Medien
    Ultrastructure of the parotid gland in the little brown bat (1984)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 210 (1984), S. 491-502 
    Details
    ISSN: 0003-276X
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The ultrastructure of the parotid gland was examined in the little brown bat. The seromucous acinar cells contained abundant granules of variable morphology. These granules were characterized by a submembranous dense layer consisting of fine parallel slats. In some bats, the matrix of the granules was structureless, whereas in others it consisted of closely packed but randomly arranged bundles of tubules. The intercalated ducts had a highly developed rough endoplasmic reticulum, often containing large numbers of intracisternal granules. In contrast, only a few secretory granules were present in the supranuclear cytoplasm. The striated ducts, which exhibited the characteristic basal striations consisting of vertically oriented mitochondria and highly folded plasmalemmas, contained numerous small dense granules in a subluminal band. These granules had a paracrystalline substructure with a periodicity of 8 nm. Excretory ducts strongly resembled striated ducts. They showed the same kind of basal striations and about half their constituent cells contained small paracrystalline granules.
    Zusätzliches Material: 16 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/ar.1092100310
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  • 10
    Digitale Medien
    Digitale Medien
    Ultrastructure of the corpus luteum of the white-tailed deer during pregnancyThis research was supported by USPHS grant AM-11376 and NIH grant 69-2136.A portion of this work was presented to the eighty-third annual session of the American Association of Anatomists in March 1970. An abstract has been published (Anat. Rec., 166: 379, '70). (1971)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 132 (1971), S. 189-205 
    Details
    ISSN: 0002-9106
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: The fine structure of corpora lutea from 14 white-tailed deer was studied from early through near-term pregnancy. The corpora contained both thecal and granulosal lutein cells. The small, elongate and cylindrical thecal lutein cells contained many lipid droplets, juxtanuclear Golgi elements, abundant agranular endoplasmic reticulum, and other cytoplasmic organelles. These cells were observed throughout pregnancy. Some of the thecal lutein cells became modified during early to midpregnancy. The modified thecal lutein cells possessed many lipid droplets, several lysosomes, packets of PAS-positive glycogen granules, and numerous small membranous whorls of agranular endoplasmic reticulum. The granulosal lutein cells had highly folded and/or ruffled plasma membranes, abundant tortuous tubular and cisternal agranular endoplasmic reticulum, numerous rod-shaped to round mitochondria with tubular and lamellar cristae, Golgi elements, and a few packets of granular endoplasmic reticulum. Many granulosal lutein cells became modified during mid- to near-term pregnancy by the addition of numerous small membrane-bound osmiophilic droplets and variable numbers of large nonmembrane-bound lipid droplets. The granulosal and thecal lutein cells appeared more active in steroid biosynthesis than the modified granulosal and thecal lutein cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aja.1001320206
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