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Digitale Medien

Ultrastructural and immunohistochemical study of degenerate neurite-bearing ghost tangles (1992)

Ikeda, K. ; Haga, C. ; Oyanagi, S. ; [weitere]

Springer

Journal of neurology 239 (1992), S. 191-194

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Details

ISSN: 1432-1459

Schlagwort(e): Ghost tangles ; Degenerate neurites ; Astrocytes ; Senile plaques ; Ultrastructure

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Some ghost tangles in the brains of Alzheimer patients were accompanied by many small argyrophilic structures which were electron microscopically confirmed to be degenerate neurites. In these ghost tangles, roughly dispersed 15 nm straight and occasional twisted tubules were penetrated by proliferated astrocytic processes. Immunohistochemically, these ghost tangles lost immunoreactivities to anti-NFT, -tau and -ubiquitin antibodies, but were thioflavine-S fluorescent, though antigenicity to β-protein was not proved. This similarity in composition of degenerate neurite-bearing ghost tangles to senile plaques might be induced by the amyloid nature of tubules, which probably provokes the reaction of neuropils.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00839138

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