ISSN:
1420-9071
Keywords:
Precocene
;
structure-activity relationship
;
effect of C-5-C-8 substitution and their combination
;
Locusta migratoria
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Structure-optimization studies of C-5-C-8-substituted precocene (P) analogues revealed that 1) compounds disubstituted asymmetrically at C-6, C-7 had an anti-allatal effect only if the C-6 side-group was shorter than that at C-7, 2) in the case of C-5, C-7 disubstitution, activity was enhanced by Me at C-5 whereas MeO caused inactivity. Effects of various other substitutions are also discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01959168
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