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  • 1
    Electronic Resource
    Electronic Resource
    A histopathological study of secondary syphilis (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 7 (1996), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives To study the histology of the skin lesions of secondary syphilis.Background Secondary syphilis is becoming less prevalent in developed countries and clinicians not familiar with the condition may resort to biopsy to elucidate the nature of a rash. It is therefore important that Dermatopathologists are aware of the histological features of secondary syphilis.Design Patients with secondary syphilis, who attended clinics held by one of us during a 10 year period and who consented to biopsy, were studied.Subjects Twenty-eight individuals.Methods Skin biopsies of representative lesions. Routine histological processing.Results The most common finding was that of an erythema multiforme pattern of papillary oedema and perivascular lympho-histiocytic infiltration (19 cases including the 2 men with HIV infection). The tissue reaction was mild in patients with macular lesions. Focal lichenoid tissue reaction (4 cases), a pseudolymphomatous appearance (1 case), and granuloma formation (3 cases) were noted in other patients. The histology of a condyloma latum was typical.Conclusions Our study serves to emphasise the importance of clinicopathological correlation in the assessment of a skin rash and to remind pathologists of secondary syphilis as an aetiological factor in macular and papular skin lesions. The mimicry of several other conditions confounds the specificity of the changes and shows that syphilis is a theoretical candidate in considering the aetiology of the changes seen. Careful scrutiny of all the histopathological features may permit a relatively refined differential diagnosis to be established and, either prospectively or retrospectively, alert the clinician to the appropriate additional investigative techniques which will allow a sound diagnosis to be attained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1996.tb00576.x
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  • 2
    Electronic Resource
    Electronic Resource
    PROFESSOR JOHN ALEXANDER MILNE M.B., Ch.B., F.R.C.P. (Lond., Edin., Glasg.), M.R.C.Path (1977)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 97 (1977), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1977.tb14140.x
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  • 3
    Electronic Resource
    Electronic Resource
    Histological findings in clinically normal skin of patients with insulin-dependent diabetes (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 12 (1987), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Biopsies of clinically normal skin of 22 young patients with insulin-dependent diabetes of varying duration (〉 10 years, n 〈 5 years, n= 10) were examined using a panel of histological stains, and compared with those of 10 non-diabetic control subjects of similar age. Abnormalities under light microscopy were scored for severity. Scores for both groups of diabetics were significantly greater than scores for controls (P 〈 0·001). Increased upper dermal vasculature and PAS posttivity of blood vessel walls were more frequent in diabetic skin than in controls, and increased with duration of disease. PAS positivity was caused in part by deposition of glyeogen in cndotheiinl cells. Clumping of elastic fibres in the upper dermis was observed in seven of the 22 skin biopsies from diabetic patients, but not in control biopsies. An inflammatory infiltrate was more frequent in diabetic skin. No association was demonstrated between the histological scores and the presence of diabetic retinopathy, or the concentration of glycosylated haemoglobin in the diabetic subjects. None of the histological features was specific to diabetic skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1987.tb01913.x
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  • 4
    Electronic Resource
    Electronic Resource
    John Alexander Milne (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 4 (1977), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1977.tb00927.x
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  • 5
    Electronic Resource
    Electronic Resource
    B-group vitamin deficiency in cultured herring
    Amsterdam : Elsevier
    Aquaculture 3 (1974), S. 387-394 
    Details
    ISSN: 0044-8486
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0044-8486(74)90004-0
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  • 6
    Electronic Resource
    Electronic Resource
    Cicatricial pemphigoid treated with intravenous immunoglobulin (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1997.tb03770.x
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  • 7
    Electronic Resource
    Electronic Resource
    A case of bullous pemphigoid and figurate erythema in association with metastatic spread of carcinoma (1973)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 88 (1973), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Clinical and laboratory findings in a case of bullous pemphigoid developing during the course of metastatic spread of rectal adenocarcinoma are presented. In addition a transient figurate erythema occurred. The possibility of a causal relationship between bullous pemphigoid and malignant disease is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1973.tb07561.x
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  • 8
    Electronic Resource
    Electronic Resource
    The histopathology of salmon tagging (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 5 (1973), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1973.tb04496.x
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  • 9
    Electronic Resource
    Electronic Resource
    The histopathology of salmon tagging (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 5 (1973), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The process of tagging large numbers of juvenile salmon Salmo salar (L.) to enable studies of their migratory pathways, is now well established. A description of the usual method used in Scotland and the immediate pathological effects of the tagging trauma on the young salmon are contained in a previous paper (Roberts et al., 1973). The purpose of the present study was to delineate the long term changes which are apparent in the tag wound at the end of the one or two year period which the majority of salmon spend at sea prior to their return to the native river to spawn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1973.tb04495.x
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  • 10
    Electronic Resource
    Electronic Resource
    Studies on the skin of plaice (Pleuronectes platessa L.) (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 5 (1973), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Eighty-nine O-group plaice from a natural population were exposed at 15°C to heavy infection by Cryptocotyle lingua cercariae. Subsequently 45 fish were retained at 15°C, whilst 44 were held at 5°C. Both groups were sampled by killing individual fish at intervals of 6,18,42 h and daily thereafter up to 710 h. Entire fish were fixed immediately in formol saline, transversely sectioned and stained by H & E, PAS, PAS-diastase, JSDB 109, Picro-Mallory, Masson's trichrome, Gram-Weigert and Alcian blue. Histopathological observations showed: (a) epidermal lesions associated with encysted metacercariae in adjacent tissues; (b) myofibrillar necrosis associated with bacteria possibly introduced by the parasite; and (c) a reactive swelling of the intermuscular septa. The progressive development of the parasite cyst and host capsule is described. Development of both was markedly inhibited at the lower temperature, but the inflammatory response at either temperature was slight. This may be evidence of a long-standing host-parasite relationship which has evolved to an advanced state of adaptation on the part of the parasite and tolerance on the part of the host.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1973.tb04453.x
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