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  • 1
    Electronic Resource
    Electronic Resource
    Immunity to influenza in ferrets (1974)
    Springer
    Medical microbiology and immunology 160 (1974), S. 33-45 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ferrets were infected with recombinant influenza A viruses which possessed either the haemagglutinin or neuraminidase antigens of A/Hong Kong/68 influenza virus. After five weeks the immunity of the animals was challenged by infection with A/HK/68 virus. Immunity to challenge infection was greatest in those ferrets with serum HI antibody to A/HK/68; the presence of NI antibody conferred a measurably lower degree of immunity. A small degree of heterotypic immunity was observed following challenge infection of ferrets previously infected with influenza virus A/PR/8/34, although the surface antigens of this virus are completely different from those of A/HK/68. Experiments in which ferrets were infected with A/HK/68 virus and subsequently challenged with the recombinant viruses confirmed the results of the first experiment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02124341
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  • 2
    Electronic Resource
    Electronic Resource
    The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection (1974)
    Springer
    Medical microbiology and immunology 160 (1974), S. 295-309 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02121445
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  • 3
    Electronic Resource
    Electronic Resource
    A histopathological study of secondary syphilis (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 7 (1996), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives To study the histology of the skin lesions of secondary syphilis.Background Secondary syphilis is becoming less prevalent in developed countries and clinicians not familiar with the condition may resort to biopsy to elucidate the nature of a rash. It is therefore important that Dermatopathologists are aware of the histological features of secondary syphilis.Design Patients with secondary syphilis, who attended clinics held by one of us during a 10 year period and who consented to biopsy, were studied.Subjects Twenty-eight individuals.Methods Skin biopsies of representative lesions. Routine histological processing.Results The most common finding was that of an erythema multiforme pattern of papillary oedema and perivascular lympho-histiocytic infiltration (19 cases including the 2 men with HIV infection). The tissue reaction was mild in patients with macular lesions. Focal lichenoid tissue reaction (4 cases), a pseudolymphomatous appearance (1 case), and granuloma formation (3 cases) were noted in other patients. The histology of a condyloma latum was typical.Conclusions Our study serves to emphasise the importance of clinicopathological correlation in the assessment of a skin rash and to remind pathologists of secondary syphilis as an aetiological factor in macular and papular skin lesions. The mimicry of several other conditions confounds the specificity of the changes and shows that syphilis is a theoretical candidate in considering the aetiology of the changes seen. Careful scrutiny of all the histopathological features may permit a relatively refined differential diagnosis to be established and, either prospectively or retrospectively, alert the clinician to the appropriate additional investigative techniques which will allow a sound diagnosis to be attained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1996.tb00576.x
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  • 4
    Electronic Resource
    Electronic Resource
    Propofol for inpatient dental anaesthesia. A comparison of propofol as sole anaesthetic agent with thiopentone and halothane for inpatient dental anaesthesia (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 43 (1988), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The induction, maintenance and recovery characteristics of propofol anaesthesia were compared with thiopentone induction and halothane maintenance in 51 spontaneously breathing, intubated patients who underwent dental surgery. Induction with thiopentone produced fewer side effects than propofol, notably pain on injection. Control of the depth of anaesthesia was better in patients who breathed halothane than in those who received intermittent bolus doses of propofol. Recovery characteristics of the two groups were similar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1988.tb09080.x
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  • 5
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    An Hypothesis concerning the Relation between Body and Mind (I) (1928)
    Sydney, N.S.W. : Periodicals Archive Online (PAO)
    Australasian Journal of Philosophy. 6 (1928) 195 
    Details
    ISSN: 0004-8402
    Topics: Philosophy
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4251-1928-006-00-000015
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  • 6
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    An Hypothesis concerning the Relationship between Body and Mind (II) (1928)
    Sydney, N.S.W. : Periodicals Archive Online (PAO)
    Australasian Journal of Philosophy. 6 (1928) 272 
    Details
    ISSN: 0004-8402
    Topics: Philosophy
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4251-1928-006-00-000016
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  • 7
    Electronic Resource
    Electronic Resource
    Influence of cell age on production and assay of mouse interferon in L-cells (1970)
    Springer
    Archives of virology 32 (1970), S. 13-18 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect ofin vitro ageing of L-cells on their sensitivity to exogenous interferon and to infection with Semliki Forest virus (SFV) was studied. The production of interferon and SFV was also quantitated in the same system. Young cells were found to be less sensitive to both interferon and SFV and to produce less interferon and SFV than did older cells. The practical implication of these results to interferon assay and production is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01241514
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  • 8
    Electronic Resource
    Electronic Resource
    Immunity to influenza in ferrets (1974)
    Springer
    Archives of virology 45 (1974), S. 99-105 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response of ferrets to inoculation with tri-(n-butyl) phosphate split influenza A/Aichi/68 virus vaccine is reported. Normal ferrets did not produce detectable levels of serum HI antibody following inoculation with a single dose of either 640 or 6400 CCA of virus vaccine but produced low titres of antibody following two inoculations of 6400 CCA of virus. This antibody was insufficient to protect the animals against challenge infection with influenza virus A/Hong Kong/68. Ferrets which had been primed by previous infection with heterotypic influenza virus A/PR/8/34, however, responded to immunization with a single dose of 640 CCA of TNBP-split A/Aichi/68 virus by the production of low titres of serum HI antibody. Following immunization these animals were found to be susceptible to challenge infection. The difference in immunogenicity between the TNBP-split vaccine and similar concentrations of whole virus vaccine given to primed ferrets is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01240546
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  • 9
    Electronic Resource
    Electronic Resource
    Immunity following intranasal administration of an inactivated, freeze-dried A/England/42/72 vaccine (1975)
    Springer
    Archives of virology 48 (1975), S. 307-316 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A group of 23 student volunteers were each inoculated intranasally with 400 IU of inactivated, freeze-dried A/England/42/72 vaccine. Only one volunteer showed a four-fold rise in serum HI antibody following immunization, and the mean increase in serum HI antibody (gmt) for all volunteers did not increase two-fold. Thirteen of the volunteers developed detectable levels of nasal wash neutralizing antibody after immunization; local antibody was most commonly found in volunteers who also produced a detectable but less than four-fold rise in serum antibody titre, and who produced nasal washings with relatively high concentrations of protein and secretory IgA. Four weeks after immunization, the vaccinees and a matched group of control subjects were inoculated with attenuated A/England/42/72 (MRC-7) virus. Evidence of infection was found in 14 of 23 (61 per cent) of control subjects and in seven of 23 (30 per cent) of immunized volunteers. This result showed a significant protection (P=0.04) against challenge virus infection for volunteers given intranasal vaccine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01317429
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  • 10
    Electronic Resource
    Electronic Resource
    Immunity to influenza in ferrets (1973)
    Springer
    Medical microbiology and immunology 159 (1973), S. 53-62 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ferrets were infected with influenza A viruses and the production of serum antibodies studied using rate-zonal ultracentrifugation techniques. Following a primary infection 19S antibody was first detected in the serum, with 7S antibody occurring later. The antibody response of ferrets after a second infection with a heterotypic influenza virus appeared to be a modified primary response but occurred later. Ferrets immunized with inactivated influenza virus vaccine after prior infection with a heterotypic influenza virus produced serum antibody to the vaccine virus; this antibody response was rapid and consisted largely of 7S antibody. A secondary antibody response was also observed following infection of ferrets previously inoculated with homologous inactivated influenza virus vaccine, although no detectable serum antibody was produced after vaccination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02122649
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