ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Four stocks (C, C-57 Bl, DBA and Swiss albino) of mice were fed a high-fat (28%), low-protein (8%), hypolipotropic diet for 3-480 days. Lipotropic activities of supplements of betaine and carnitine were evaluated. There were no strain-limited hepatic responses to the diet or to the action of the lipotropes. Without lipotropic supplements, parenchymal liposis (sudanophilia of frozen sections) was progressively incremental in all lobular zones for approximately 90 days. Subsquently, lobular liposis decreased and the remaining fat was concentrated in the middle zone within cords of fat-laden cells radiating in a stellate pattern. With choline supplemention, liposis was limited to small amounts of fat within cells that composed the stellate pattern. Betaine displayed a level of lipotropic activity approximating one-half to three-fourths that of choline. The lipotropic activity of carnitine was marginal and inconsistent. The combination of betaine and carnitine demonstrated some synergistic action. No parenchymal hyperplasia was observed. The intralobular reticulum increased in some livers, primarily around the central and intercalated veins, but no lobular distortion resulted.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091490411
Permalink
