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  • 1975-1979  (6)
  • 1976  (6)
Source
Material
Years
  • 1975-1979  (6)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    The pharmacokinetics of beta-methyl digoxin compared with digoxin tablets and capsules (1976)
    Springer
    European journal of clinical pharmacology 10 (1976), S. 231-236 
    Details
    ISSN: 1432-1041
    Keywords: Digoxin ; beta-methyl-digoxin ; capsules ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The intestinal absorption and urinary elimination rate of total cardioactive material was compared following digoxin and beta-methyldigoxin (BMD) administration to twelve healthy volunteers. Significantly more injected digoxin was recovered in urine. Urinary clearance was more rapid for digoxin, mean half-lives of elimination being 35 hours for digoxin and 40 hours for BMD. Calculated percentage intestinal absorption was lowest for digoxin tablets with a dissolution rate of 77% in one hour, intermediate for BMD tablets, and maximal for an experimental soft gelatin formulation of digoxin in solution. Respective mean values were 75%, 87% and 97%. Similar steady state plasma concentrations followed twice daily ingestion of the 0.25 mg digoxin tablets and 0.20 mg BMD tablets. Mean peak plasma concentration and percentage urinary recovery of ingested dose were higher during continued BMD administration. Between-subject variation in absorption was higher for the digoxin tablets. The comparative intestinal absorption of BMD and digoxin depends upon the formulation. Digoxin is virtually completely absorbed from a solution encapsulated in soft gelatin. Relatively more BMD is eliminated by nonrenal routes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558334
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Selective inhibition of neuronal GABA uptake by cis -1,3-aminocyclohexane carboxylic acid (1976)
    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 281-284 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the present study, we have found that a confor-mationally restricted structural analogue of GABA, cis-l,3-aminocyclohexane carboxylic acid (ACHC) (Fig. 1), which has previously been reported to competitively inhibit GABA transport in slices of cerebral cortex1, selectively inhibits neuronal ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/264281a0
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    Paper (German National Licenses)
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  • 3
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    Unknown
    The Worldly Christian: Matthias Claudius as a Critic of his Time (1976)
    Cambridge : Periodicals Archive Online (PAO)
    The Modern language review. 71:4 (1976:Oct.) 827 
    Details
    ISSN: 0026-7937
    Topics: Linguistics and Literary Studies
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0094-1976-071-04-000010
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Chromosome-specific control of chiasma formation in Crepis capillaris (1976)
    Springer
    Chromosoma 57 (1976), S. 33-49 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An experimental population of Crepis capillaris (2n=6) displays frequent chromosome-specific univalence affecting all three chromosome pairs of the complement independently in different plants. The frequency of univalence in the population varies from 0% in some plants to about 40% of pollen mother cells in other plants. Most commonly, affected pollen mother cells contain just one pair of univalents and wherever the frequency of cells containing univalents exceeds 10%, a chromosome-specific effect almost invariably appears. Univalence affecting the A, C and D chromosome pairs is about equally frequent in the population. The mean cell chiasma frequencies of affected plants are generally lower than those of normal plants from the same population, despite suggestions of compensating increases in the chiasma frequencies of unaffected chromosomes pairs in the presence of specific univalence of a third pair. Breeding tests have been carried out, and observations made on pachytene stages which demonstrate that the specific univalence is due to recessive genes causing desynapsis following apparently normal pairing of homologues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292949
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Mycoflora of activated sewage sludge (1976)
    Springer
    Mycopathologia 58 (1976), S. 115-116 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Thirty-eight species of fungi were identified in pure culture after isolation from activated sewage sludge by serial dilution. Nine species and genera were identified that had not been previously reported. In 1963, Cooke (1) published an excellent laboratory guide on the identification of fungi from polluted water, sewage, and sewage treatment systems; of approximately 30 papers cited only one (2) dealt with fungi from activated sewage sludge. Later (1970), Cooke & Pipes (3) enumerated 47 fungi consisting of 4 genera of yeasts and 33 genera of filamentous fungi that had been isolated from activated sludge. This paper reports the mycoflora of anaerobically digested sludge from a residential area in Auburn, Alabama.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00707182
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    A procedure for specifically selecting temperature sensitive mutants of tobacco mosaic virus (1976)
    Springer
    Molecular genetics and genomics 145 (1976), S. 307-309 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A procedure is described that permits the selection of functionally deficient, temperature sensitive mutants of tobacco mosaic virus based upon the time of local lesion formation on the appropriate host plant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00325828
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    Paper (German National Licenses)
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