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  • 1
    Electronic Resource
    Electronic Resource
    EFFECT OF SOME PROSTAGLANDIN SYNTHESIS INHIBITORS ON THE ANTINOCICEPTIVE ACTION OF MORPHINE IN ALBINO RATS (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 5 (1978), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Five prostaglandin synthesis inhibitors, indomethacin, diclofenac, mefenamic acid, ibufen and paracetamol, were found to inhibit the antinociceptive action of morphine without affecting the antinociceptive response of an equi-analgesic dose of prostaglandin E12. Diclofenac was found to be the most potent and longest acting, whereas paracetamol was the least potent and shortest acting. Indomethacin, mefenamic acid and ibufen occupied an intermediate position, both in potency and duration of action.3. The results suggest that prostaglandins may be involved in the antinociceptive action of morphine in albino rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1978.tb00703.x
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  • 2
    Electronic Resource
    Electronic Resource
    Bovine TSH-stimulation of fish thyroid peroxidase activity and role of thyroxine thereon (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 136-137 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary bTSH augmented the fish thyroid peroxidase activity in a dose-response manner. Thyroxine could not modulate the effect of exogenous bTSH, but it decreased the peroxidase activity in a control system when administered alone. The data therefore suggest similar negative feedback control system for TSH-regulation as operative in the case of mammals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01921948
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Anticonvulsant action of cannabis in the rat: Role of brain monoamines (1978)
    Springer
    Psychopharmacology 59 (1978), S. 293-297 
    Details
    ISSN: 1432-2072
    Keywords: Cannabis indica ; Anticonvulsant action ; Brain monoamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of brain monoamines in the anticonvulsant action of Cannabis indica resin (CI), against maximal electroshock-induced seizures in albino rats, was investigated by using pharmacologic agents that influence brain monoamine activity. Delta-9-tetrahydrocannabinol content of cannabis resin was estimated to be 17%. The anticonvulsant action of CI (200 mg/kg, i.p.) was significantly inhibited after pretreatment with drugs that reduce brain serotonin activity but not by drugs that reduce brain catecholamine activity. Similarly, the anticonvulsant action of a subanticonvulsant dose (50 mg/kg, i.p.) of CI was potentiated by serotonin precursors but not by catecholamine precursors. Potentiation of the anticonvulsant action of CI by nialamide or by imipramine was inhibited after pretreatment with 5,6-dihydroxytrypt-amine. The results suggest that the anticonvulsant action of CI in the rat is serotonin- and not catecholamine-mediated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426637
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition of pentylenetetrazol-induced convulsions in rats by prostaglandin E1: Role of brain monoamines (1978)
    Springer
    Psychopharmacology 56 (1978), S. 235-237 
    Details
    ISSN: 1432-2072
    Keywords: Pentylenetetrazol ; Clonic convulsions ; PGE1 ; PGF2α ; Serotonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Prostaglandin E1-(PGE1-) induced inhibition of pentylenetetrazol (PTZ) convulsions in rats were significantly antagonized after pretreatment with drugs known to reduce brain serotonin activity, but not by pharmacological agents that decrease brain catecholamine activity. PGF2α also significantly inhibited PGE1 action. The results suggest that PGE1-induced inhibition of PTZ convulsions is not a direct effect, but an indirect one mediated through increase in brain serotonin activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431857
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  • 5
    Electronic Resource
    Electronic Resource
    Psychopharmacological studies on (-)-nuciferine and its Hofmann degradation product atherosperminine (1978)
    Springer
    Psychopharmacology 59 (1978), S. 29-33 
    Details
    ISSN: 1432-2072
    Keywords: Aporphine alkaloid and derived arylethylamine ; Nuciferine ; Neuroleptic ; Atherosperminine ; Dopamine-receptor agonist/antagonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract (-)-Nuciferine and its Hofmann degradation product atherosperminine showed divergent psychopharmacological effects. Because nuciferine has been reported to be a neuroleptic and atherosperminine has some chemical resemblance to dopamine, they were investigated for their dopamine-receptor activities. Nuciferine had a pharmacologic profile of action associated with dopamine-receptor blockade; i.e., it induced catalepsy, inhibited spontaneous motor activity, conditioned avoidance response, amphetamine toxicity and stereotypy. On the other hand, atherosperminine produced effects associated with dopamine receptor stimulation, i.e., stereotypy, increase in spontaneous motor activity and amphetamine toxicity, reversal of haloperidol-induced catalepsy and inhibition of conditioned avoidance response, inhibition of morphine analgesia, and potentiation of the anticonvulsant action of diphenylhydantoin. The results are discussed on the basis of the chemical configuration of the two compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428026
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  • 6
    Electronic Resource
    Electronic Resource
    Orbital optimization techniques: Comparative study in a semiempirical framework (1978)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 14 (1978), S. 289-297 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: In this paper, MC-SCF and CI methods have been explored for the calculation of ground- and excited-state energies of some aromatic heterocycles in the PPP framework. A new algorithm for solving the orbital equations in MC-SCF theory has been suggested and its performance has been compared with the conventional gradient optimization technique. Energies of first few transitions have been calculated and compared with rather extensive CI results.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560140307
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