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Digitale Medien

Effect of rearing density on thyroid and interrenal gland activity and plasma and hepatic metabolite levels in rainbow trout, Salmo gairdneri Richardson (1985)

Leatherland, J. F. ; Cho, C. Y.

Oxford, UK : Blackwell Publishing Ltd

Journal of fish biology 27 (1985), S. 0

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ISSN: 1095-8649

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Biologie

Notizen: There were significant inverse correlations between rearing density of rainbow trout, Salmo gairdneri Richardson, and final body weight, plasma L-thyroxine (T4), trüodo-L-tryronine (T3), cortisol and protein concentrations, plasma T4/T3 ratios and thyroid epithelial cell height. In addition, hepatosomatic indices and plasma free fatty acid concentrations were higher in fish reared at low (134 g 1−1) density compared with groups reared at medium (210g1−1) or high density (299g 1−1), and the post-feeding (3.5-4h) elevation in plasma glucose and triglyceride levels evident in trout maintained at low rearing density was not found in those fish reared at higher densities. There were no significant effects of rearing density on hematocrit, carcass composition, hepatic glycogen and lipid levels and interregnal nucleus size.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1095-8649.1985.tb03203.x

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Digitale Medien

The effect of nicotine on ethanol-induced gastric ulcers in rats (1985)

Ogle, C. W. ; Cho, C. H. ; Wong, S. H.

Springer

Cellular and molecular life sciences 41 (1985), S. 1140-1141

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ISSN: 1420-9071

Schlagwort(e): Nicotine ; ethanol ; gastric ulcers

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary Nicotine, in concentrations of 5 and 25 μg/ml drinking water, given ad libitum for 10 days, dose-dependently increased lesion formation and worsened ethanol-induced ulceration in rat stomachs. Daily fluid intake and b.wt gain were not adversely affected by nicotine pretreatment.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01951697

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Digitale Medien

Sulphasalazine and experimental stress ulcers (1985)

Ogle, C. W. ; Cho, C. H. ; Dai, S.

Springer

Inflammation research 17 (1985), S. 153-157

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ISSN: 1420-908X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The effects of sulphasalazine on gastric ulceration induced by restraint at 4°C (stress) for 2 h were studied in rats. Doses of 63 or 125 mg/kg s.c., which had no effect on stomach wall prostaglandin E2 (PGE2) levels, prevented stress ulceration but not the lesions produced by indomethacin. Stress significantly increased gastric glandular mucosal PGE2 levels. Indomethacin pretreatment (20 mg/kg, p.o.) markedly reduced PGE2 levels in the same region of the stomachs, and worsened stress-induced lesion formation. Pretreatment with sulphasalazine of animals given indomethacin and then subjected to stress did not appear to affect the indomethacin component of indomethacin-stress ulceration. Oral administration of PGE2 200 μg/kg significantly elevated gastric PGE2 levels, but had no effect on stress ulceration. It appears that neither the antiulcer activity of sulphasalazine nor stress-induced ulceration is associated with gastric tissue PGE2 increase or decrease, respectively. The protective mechanism may result from the ability of sulphasalazine to inhibit lipoxygenase activity.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01966585

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Digitale Medien

Heparinized polyurethanes: In vitro and in vivo studies (1985)

Heyman, P. W. ; Cho, C. S. ; McRea, J. C. ; [weitere]

Hoboken, NJ : Wiley-Blackwell

Journal of Biomedical Materials Research 19 (1985), S. 419-436

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ISSN: 0021-9304

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Medizin , Technik allgemein

Notizen: Heparin immobilization chemistry using alkyl spacer arms was adapted to optimize yield on polyurethane (PU) surfaces. The resultant biological activity of immobilized heparin (HI) was examined in vitro and in vivo, and compared with a heparin releasing (HR) system. Immobilized heparin retained its ability to bind and inactivate thrombin and Factor Xa; nonspecific coagulation factor binding was insignificant. Such activity cannot be attributed to the leakage of improperly bound heparin. Immobilized heparin-polurethane catheters implanted in canine femoral and jugular veins for 1 h periods exhibited significant reduction in thrombus formation compared with untreated PU contralateral controls. Polyurethane catheters coated with a 9% heparin dispersion in PU (HR) system provided even greater improvement in antithrombogenicity.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jbm.820190407

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