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  • 1
    Digitale Medien
    Digitale Medien
    Preoperative detection of a highly malignant type of early gastric carcinoma by cytophotometric DNA analysis (1986)
    Springer
    Surgery today 16 (1986), S. 169-174 
    Details
    ISSN: 1436-2813
    Schlagwort(e): DNA pattern ; growth pattern ; malignancy ; early gastric carcinoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A cytophotometric DNA analysis was made of gastroendoscopically biopsied materials of 43 patients with early gastric carcinoma and the data were compared with the DNA patterns of the resected specimens of these patients. The DNA patterns could be classified into two types, Low Ploidy and High ploidy, according to the degree of dispersion of the DNA value. The Ploidy to Ploidy coincidence of the DNA patterns between biopsied material and the resected specimen in the same lesion was noted in 93 per cent (39/42). The DNA patterns of the resected specimens were consistent in the majority of cases, regardless of the areas examined, center or periphery, and mucosa or submucosa of the same lesion. This study provides evidence that a highly malignant type of early gastric carcinoma, Pen A type, could be differentiated in gastroendoscopically biopsied materials by a cytophotometric DNA analysis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02471089
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  • 2
    Digitale Medien
    Digitale Medien
    Postoperative adjuvant chemotherapy for gastric cancer, the second report. Analysis of data on 2873 patients followed for five years (1986)
    Springer
    Surgery today 16 (1986), S. 175-180 
    Details
    ISSN: 1436-2813
    Schlagwort(e): gastric cancer ; adjuvant chemotherapy ; futraful
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effectiveness of combination chemotherapy with mitomycin-C (MMC) plus futraful (N1-(2′-tetrahydrofuryl)-5-fluorouracil), as an adjunct to surgery for gastric cancer was investigated in a prospective randomized controlled study. Three thousand and thirty-three Japanese patients in 344 hospitals were entered and 2873 could be followed for 5 years. All patients had undergone gastrectomy from April 1977 to May 1979 and were assigned, at random, to either Groups A, B or C. In Group A, bolus MMC was administered with no further treatment. In Group C, oral futraful was given for one year, without MMC induction. In Group B, both a bolus MMC injection and oral futraful were prescribed. This randomized study showed no statistical difference in the 5 year survival rate among the three groups. However, in patients given MMC and put on oral futraful for one year, the 5 year survival rate for those with stage III gastric cancer or for those with positive lymphnode metastasis plus obvious serosal invasion seemed to be improved.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02471090
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  • 3
    Digitale Medien
    Digitale Medien
    Development of erosive gastritis in a canine model of esophageal varices (1986)
    Springer
    Surgery today 16 (1986), S. 218-224 
    Details
    ISSN: 1436-2813
    Schlagwort(e): erosive gastritis ; esophageal varices ; hyperdynamic state ; gastric mucosal blood flow
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We designed a reproducible canine model of esophageal varices, based on the concept of a regional hyperdynamic state in the upper stomach. Arterialization of the left gastric vein concomitant with the distal splenorenal shunt led to a stable hyperdynamic state and reproducible esophageal varices occurred. In the long-term follow-up of these dogs with varices, the erosive gastritis seen in the upper stomach learly resembled clinically observed lesions. Hemodynamic and morphological studies revealed that gastric mucosa of these animals was in an ischemic state, even though there was a remarkable increase in blood flow in the submucosal area. It is suggested that the decrease in mucosal blood flow, as induced by the hyperdynamic state caused erosive gastritis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02471096
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  • 4
    Digitale Medien
    Digitale Medien
    A cohort study on second malignancies in gastrectomized patients with gastric cancer I. Second malignancies other than cancer of the gastric remnant (1986)
    Springer
    Surgery today 16 (1986), S. 336-343 
    Details
    ISSN: 1436-2813
    Schlagwort(e): second malignancies ; cohort study ; gastric cancer ; adjuvant chemotherapy ; gastrectomy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In a retrospective cohort study, a total of 235 (2.32 per cent) second malignancies were clinically observed in 10,138 patients during the average 8.8-year follow-up period. The patients had undergone gastrectomy for gastric cancer during 1960–1975, in seven different institutions. This observed number was smaller than the expected one of 340.9 (p〈0.01). Among the 235, cancers of the gastrointestinal tract (111) were the most frequent and followed by respiratory (54) and urogenital (25) cancers. Twelve cases of malignant lymphoma and five of leukemia were also noted. With regard to adjuvant chemotherapeutic agents such as mitomycin-C (MMC), 5-fluorouracil (5FU) or its derivative Tegafur, and cyclophosphamide (EDX), no significant differences in the rate of second malignancies were obtained between the chemotherapy and non-chemotherapy groups. The occurrence rate of second malignancies tended to be higher in the Billroth II group than in the Billroth I, the significance of which is yet to be determined.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02470556
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  • 5
    Digitale Medien
    Digitale Medien
    A cohort study on second malignancies in gastrectomized patients with gastric cancer II. Second maliganacies in the gastric remnant (1986)
    Springer
    Surgery today 16 (1986), S. 344-350 
    Details
    ISSN: 1436-2813
    Schlagwort(e): cancer of gastric remnant ; cohort study ; gastric cancer ; adjuvant chemotherapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In a retrospective cohort study, a total of 22 (0.22 per cent) carcinomas of the gastric remnant were clinically observed, as second malignancies, in 7,672 patients during the average of a 9.4-year follow-up period. All had undergone distal subtotal gastrectomy for gastric cancer from 1960–1975 in seven different institutions. Of 22 carcinomas of the gastric remnant, 5 were at the anastomotic site, 14 distant from the anastomosis; the location was unknown in three. All five carcinomas of the anastomotic site occurred after Billroth II operation. Time intervals between the first operation and the occurrence of second cancer varied from two to 21 years. With regard to the administration of adjuvant chemotherapeutic agents such as mitomycin-C (MMC), 5-fluorouracil (5FU) or its derivative Tegafur, no significant differences in the rate of second malignancies were obtained between the chemotherapy and non-chemotherapy groups. The occurrence rate of cancer of the gastric remnant between Billroth I and Billroth II groups showed no statistically significant difference, although it did tend to be slightly higher in the latter.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02470557
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