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  • 1985-1989  (3)
  • 1986  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of TZU-0460, a new H2-receptor antagonist, in patients with impaired renal function (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 709-712 
    Details
    ISSN: 1432-1041
    Keywords: TZU-0460 ; renal failure ; H2-receptor antagonist ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied pharmacokinetics of a new H2-receptor antagonist, TZU-0460, in patients with varying degrees of renal impairment. The apparent volume of distribution at steady-state was 1.70 l/kg, and the plasma protein binding of TZU-0460 or its active metabolite, desacetyl TZU-0460 was less than 10% in normal subjects. These variables were not altered with renal impairment. Sixty percent of TZU-0460 given orally was excreted via the kidney, mainly by tubular secretion. The half-time of elimination was 3.94 h in normal subjects, and was prolonged to 12.13 h in severe renal failure (creatinine clearance below 30 ml/min/1.48 m2). Dosage adjustment of TZU-0460 is necessary in renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00608220
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Deletion 14q(q24.3 to q32.1) syndrome: significance of peculiar facial appearance in its diagnosis, and deletion mapping of (α1-antitrypsin) (1986)
    Springer
    Human genetics 〈Berlin〉 74 (1986), S. 190-192 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A 10-month-old Japanese boy who had interstitial deletion of the long arm of chromosome No. 14; 46,XY, del(14)(pter»q24.3::q32.1»qter) is reported. A peculiar facial appearance, including round face, frontal hypertrichosis with thick eyebrows, horizontal narrow palpebral fissures, a short bulbous nose with a flat nasal root, and mild micrognathia, appeared to be common with the two previously reported cases. We stress the significance of this peculiar facial appearance in the diagnosis of 14q-(q24.3 to q32.1) syndrome. The level of α1-antitrypsin in the patient was only about half of that of his parents and controls, and the Pi locus was tentatively assigned to band 14q32.1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282092
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Characteristics of skin admittance for dry electrodes and the measurement of skin moisturisation (1986)
    Springer
    Medical & biological engineering & computing 24 (1986), S. 71-77 
    Details
    ISSN: 1741-0444
    Keywords: Bioimpedance ; Dehydration measurement ; Skin admittance ; Skin moisturisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The properties of skin adminttance were investigated with the intention of applying them to skin moisturisation measurement. Skin admittance is determined by measuring relative permittivity and the resistivity of the stratum corneum, and by contact ratio between dry electrode and stratum corneum. It was found, however, that the contact ratio is the predominant factor producing the change of skin admittance induced by changes in the water content of skin. To measure skin admittance, the following conditions were found to be approriate: (a) frequency of about 100 kHz; (b) concentric electrodes, the diameter of the measuring (inner) electrode being about 5 mm, and (c) an electrode pressure of about 100 g cm−2. Based on these optimal conditions, a system for measuring skin admittance was constructed. All measuring procedures were automated. Experimental observations made with this system have indicated its usefulness for the measurement of skin moisturisation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02441608
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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