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  • 1985-1989  (3)
  • 1986  (3)
Materialart
Erscheinungszeitraum
  • 1985-1989  (3)
Jahr
  • 1
    ISSN: 1432-1041
    Schlagwort(e): TZU-0460 ; renal failure ; H2-receptor antagonist ; pharmacokinetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary We have studied pharmacokinetics of a new H2-receptor antagonist, TZU-0460, in patients with varying degrees of renal impairment. The apparent volume of distribution at steady-state was 1.70 l/kg, and the plasma protein binding of TZU-0460 or its active metabolite, desacetyl TZU-0460 was less than 10% in normal subjects. These variables were not altered with renal impairment. Sixty percent of TZU-0460 given orally was excreted via the kidney, mainly by tubular secretion. The half-time of elimination was 3.94 h in normal subjects, and was prolonged to 12.13 h in severe renal failure (creatinine clearance below 30 ml/min/1.48 m2). Dosage adjustment of TZU-0460 is necessary in renal failure.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary A 10-month-old Japanese boy who had interstitial deletion of the long arm of chromosome No. 14; 46,XY, del(14)(pter»q24.3::q32.1»qter) is reported. A peculiar facial appearance, including round face, frontal hypertrichosis with thick eyebrows, horizontal narrow palpebral fissures, a short bulbous nose with a flat nasal root, and mild micrognathia, appeared to be common with the two previously reported cases. We stress the significance of this peculiar facial appearance in the diagnosis of 14q-(q24.3 to q32.1) syndrome. The level of α1-antitrypsin in the patient was only about half of that of his parents and controls, and the Pi locus was tentatively assigned to band 14q32.1.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Medical & biological engineering & computing 24 (1986), S. 71-77 
    ISSN: 1741-0444
    Schlagwort(e): Bioimpedance ; Dehydration measurement ; Skin admittance ; Skin moisturisation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract The properties of skin adminttance were investigated with the intention of applying them to skin moisturisation measurement. Skin admittance is determined by measuring relative permittivity and the resistivity of the stratum corneum, and by contact ratio between dry electrode and stratum corneum. It was found, however, that the contact ratio is the predominant factor producing the change of skin admittance induced by changes in the water content of skin. To measure skin admittance, the following conditions were found to be approriate: (a) frequency of about 100 kHz; (b) concentric electrodes, the diameter of the measuring (inner) electrode being about 5 mm, and (c) an electrode pressure of about 100 g cm−2. Based on these optimal conditions, a system for measuring skin admittance was constructed. All measuring procedures were automated. Experimental observations made with this system have indicated its usefulness for the measurement of skin moisturisation.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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