ISSN:
1432-072X
Keywords:
Halobacterium halobium
;
Alpha like DNA polymerase
;
Oncogene v-myc
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Partial DNA sequencing of a genomic clone of the archaebacterium Halobacterium halobium, which hydridized with an avian v-myc probe, showed especially the presence, in the organism of one of the conserved regions through myb, myc and adenovirus E1a oncogenes. The archaebacterial deduced amino acid sequence displayed significant homology with the v-myc gene product. In accordance with the partial DNA sequencing which assured a sufficient homology to have similar epitopes, a protein having a molecular weight of 70,000 and possessing high antigenicity with a polyclonal antiserum against avian v-myc protein was isolated and purified from H. halobium extracts. The purified v-myc like protein stimulated in vitro DNA synthesis carried out by the alpha like DNA polymerase of H. halobium.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00422002
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