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Digitale Medien

Decreased bradykinin binding sites in fibroblasts from progressive systemic scleroderma (1994)

Ozeki, T. ; Osada, K. ; Seishima, M. ; [weitere]

Springer

Archives of dermatological research 286 (1994), S. 133-136

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ISSN: 1432-069X

Schlagwort(e): Bradykinin receptor ; Progressive systemic sclerosis ; Fibroblast

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The numbers of bradykinin receptors (BK-R) in cultured dermal fibroblasts from patients with progressive systemic sclerosis (PSS) and from healthy controls were measured using a receptor binding assay. The numbers of BK-R were significantly fewer in PSS fibroblasts than in control fibroblasts (P〈0.02). However, no differences in affinity were observed in BK-R between PSS and control fibroblasts. The BK-R mRNA levels were determined in PSS and control fibroblasts by Northern blot hybridization using BK-R cDNA, but no significant differences were found. These findings suggest that the decrease in BK-R in PSS fibroblasts might occur during a posttranslational step.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00374207

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