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  • 1
    ISSN: 1432-1750
    Schlagwort(e): Aging ; Glutathione ; Bronchoalveolar lavage (BAL)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We studied the influence of age on glutathione (GSH) content in the distal lung and the lung tissue of mice. From 1 to 28 months of age, the quantity of GSH and glutathione disulfide (GSSG) in bronchoalveolar lavage (BAL) fluid and in the lung tissue were determined. The GSH content in BAL fluid, which reflects the antioxidant screen of the distal lung, decreased with advancing age. The ratio of GSSG to GSH increased in later life, suggesting increase of oxidation of the epithelial lining fluid in old mice. The GSH content in the lung tissue also decreased with aging. Therefore the lower respiratory tract may be less able to defend against external attack, including attack by oxygen-derived active molecules, in senescent mice. The decrease of the antioxidant screen of the distal lung may be associated with impaired lung defense in relation to oxidant-antioxidant balance in aged mice.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 0942-0940
    Schlagwort(e): Elderly meningioma ; clinical feature ; prognostic implication
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary During the 5 years from 1987 to 1991, 89 elderly patients, aged 70 years and over, were admitted to departments of neurosurgery in Yamaguchi prefecture with meningioma. The clinical features and prognostic implications of meningioma in the elderly were assessed retrospectively. Seventy-eight (88%) of the 89 patients underwent surgery, which was a higher rate than has been previously reported. The length of clinical history was also shorter than in previous studies, and was partly due to the recent introduction of magnetic resonance imaging (MRI). The incidence of poor prognosis (severe disability, vegetative or dead) in the elderly and a younger group aged less than 70 years was 13% and 7%, respectively, but the difference was not statistically significant. In the surgically treated elderly group, age did not influence the patient's outcome. The factors affecting the outcome were pre-operative neurological deficit (p〈0.05), histological malignancy (p〈0.05), and multiple operations (p〈0.05). Twenty-seven of the elderly meningioma patients were in good physical condition with minimal neurological involvement. They underwent total removal of the tumour at the first operation, and the histological diagnosis was benign. Twenty-five of these 27 patients fell into the best outcome category. Therefore, age alone was not a factor preventing proper surgical treatment of meningioma in the elderly.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1432-0983
    Schlagwort(e): Overexpression ; Peroxisomes ; Saccharomyces cerevisiae ; Stabilization
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract We have constructed a gene coding for the 12-kDa intermediate form of the 2s methionine-rich protein from Bertholletia excelsa seeds. This protein, expressed intracellularly in yeast, is characterised by a 20-min balf-life. By adding 11 amino acids corresponding to the peroxisome-targeting sequence (PTSc) of luciferase, we have significantly increased its half-life. This stabilization allowed accumulation of the BZN protein into the peroxisome as judged by cell fractionation. Accumulation of the 12-kDa protein results in a significant increase of the total methionine content in yeast cells (30%) indicating that such a microorganism could represent a practicable protected shuttl for an animal-feed additive.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    ISSN: 1432-0584
    Schlagwort(e): Plasma cell leukemia ; Myelofibrosis Chemotherapy ; Bone marrow biopsy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We describe a case of plasma cell leukemia associated with myelofibrosis. A 60-year-old woman was admitted due to lumbago and monoclonal hypergammaglobulinemia. Peripheral blood showed about 40% of plasma-cell-like cells. A bone marrow aspiration was dry tap. The patient was diagnosed as having plasma cell leukemia with myelofibrosis by bone marrow biopsy. Plasma cell leukemia as well as myelofibrosis improved with combination chemotherapy using vincristine, pirarubicin, and dexamethasone. However, when plasma cell leukemia became resistant to chemotherapies, myelofibrosis also reappeared. This case strongly suggests the pathogenetic relationship between plasma cell leukemia and myelofibrosis.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Journal of superconductivity 7 (1994), S. 657-661 
    ISSN: 1572-9605
    Schlagwort(e): Organic superconductors ; molecular superconductors ; antiferromagnetism ; weak ferromagnetism ; Fermi surface nesting
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Physik
    Notizen: Abstract The Fermi surface studies of layered BEDT-TTF salts have shown that some of them possess two kinds of bands; quasi 1D and 2D bands. The latter may work for superconductivity while the former for SDW. The interplay of the superconductivity with the magnetic ordering based on different Fermi surfaces have emerged as intriguing subjects in (BEDT-TTF)2 MHg(SCN)4 (M=NH4, K, Tl, Rb), and in (BEDT-TTF)2Cu[N(CN)2]Cl, where the interplay appears in different manners. They are compared to the cases for ternary and actinide compounds.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 6
    ISSN: 1572-9605
    Schlagwort(e): Organic superconductor ; reentrant superconductivity ; temperature-pressure phase diagram ; magnetic-field-induced phase transition
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Physik
    Notizen: Abstract Systematic experimental study of the electrical transport and static magnetization reveals a direct and delicate interplay between magnetism and superconductivity in the organic materialκ-(BEDT-TTF)2Cu[N(CN)2]Cl, displayed through the specific temperature-pressure phase diagram, and such new effects for organic solids as the reentrant superconductivity in zero applied magnetic field and high-field-induced interchange between superconductivity and the nonmetallic resistive phase in the high-pressure region.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 7
    ISSN: 1572-9540
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The formation of magnetite microcrystals in an aqueous solution containing stoichiometric quantities of iron chlorides and polyvinyl alcohol (PVA) at 90 °C has been studied by means of Mössbauer spectroscopy and X-ray diffraction. The crystallite size of the microcrystals was estimated to be 100–200 Å in diameter.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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