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DECREASED EXPRESSION OF THE VERY LOW DENSITY LIPOPROTEIN RECEPTOR mRNA IN THE CARDIAC VENTRICLE OF SPONTANEOUSLY HYPERTENSIVE RATS (1995)

Jingami, H. ; Masuzaki, H. ; Matsuoka, N. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Clinical and experimental pharmacology and physiology 22 (1995), S. 0

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ISSN: 1440-1681

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: 1. To elucidate the functional implication of very low density lipoprotein (VLDL) receptor, we studied the gene expression of VLDL receptor in rats. The VLDL receptor mRNA was highly expressed in the cardiac ventricle and skeletal muscle. Intermediate amounts of VLDL receptor mRNA were detected in adipose tissue, adrenal gland, brain and lung. Thus the tissue distribution of VLDL receptor mRNA in rats was similar to that reported previously in rabbits.2. We studied the gene expression of the VLDL receptor in the heart of stroke-prone spontaneously hypertensive rats (SHRSP), an animal model for hypertension-induced cardiac hypertrophy. RNase protection assay showed that the level of ventricular VLDL receptor mRNA was already decreased to one half when hypertension was not fully developed, and further diminished to one fifth when cardiac hypertrophy was established.3. It is reported that energy utilization in SHRSP hypertrophied myocardium is impaired. Our results suggest that inactive fatty acid metabolism in the ventricle of SHRSP is related to the lowered expression of the VLDL receptor which is postulated as a gate for triglyceride-rich lipoprotein particle.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb02902.x

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An improved apparatus for the determination of krypton-85 and xenon-133 in an emergency situation (1988)

Matsuoka, N. ; Momoshima, N. ; Okai, T. ; [et al.]

Springer

Journal of radioanalytical and nuclear chemistry 120 (1988), S. 21-27

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ISSN: 1588-2780

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering

Notes: Abstract A simple and portable apparatus was developed for measurements of85Kr and133Xe that would be released into the atmosphere in an emergency situation of nuclear facilities. The method is based on cryogenic adsorption of these gases on charcoal followed by chromatographic separation from other gases. The85Kr and133Xe recovered from atmospheric air are determined separately by liquid scintillation counting. It takes about 1 hour for the stepwise determination of85Kr and133Xe. The atmospheric concentration of 3·10−3 μCi per m3 air (1.1·102 Bq/m3 air) is measurable for both nuclides with 20% counting error.