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  • 2005-2009  (11)
  • 1870-1879  (9)
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  • 1
    Digitale Medien
    Digitale Medien
    Paraneoplastic pityriasis lichenoides in cutaneous lymphoma: case report and review of the literature on paraneoplastic reactions of the skin in lymphoma and leukaemia (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 152 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Paraneoplastic dermatoses are non-neoplastic skin disorders which occur in the context of an underlying malignant neoplasm. The classic paraneoplastic dermatoses are mostly associated with solid internal malignancies. They only rarely occur in the context of nodal or primary cutaneous lymphomas. Apart from these classic paraneoplastic dermatoses, there are additional skin disorders reported to occur in close association with haematological and lymphoproliferative disorders which can thus be regarded as paraneoplastic manifestations. We report for the first time two patients with pityriasis lichenoides et varioliformis acuta in association with mycosis fungoides. In addition, we review the literature on paraneoplastic dermatoses of the skin which have been described in patients with leukaemias and primary cutaneous lymphomas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06457.x
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  • 2
    Digitale Medien
    Digitale Medien
    Apoptosis in CD30-positive lymphoproliferative disorders of the skin (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Experimental dermatology 14 (2005), S. 0 
    Details
    ISSN: 1600-0625
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract:  The spectrum of CD30-positive cutaneous lymphoproliferative disorders (CD30+ CLPD) includes lymphomatoid papulosis (LyP), primary cutaneous CD30+ large T-cell lymphoma (LTCL) and rare borderline patients. Despite their malignant histopathology, CD30+ CLPD exhibit a low-grade malignant course with an excellent prognosis and a characteristic tendency for spontaneous regression. Apoptosis of tumour cells is considered a principal mechanism of tumour regression. We examined the proliferation and apoptosis rates as well as the expression of apoptosis-related proteins in various clinical entities, tumour cell lines and evolutional (evolving and regressing) stages of CD30+ CLPD. Skin biopsies of LyP (n = 20) and LTCL (n = 19) and five CD30+ lymphoma cell lines were analysed by means of immunohistochemistry and Western blotting in order to evaluate the proliferation (Ki67), apoptosis (FragEl) and expression of Bax, Bcl-x, C-kit and Mcl-1. A significantly higher apoptotic index (AI) was found in LyP (AI = 12.5%) than in LTCL (AI = 3.1%, P 〈 0.005). Bax was expressed by the majority of tumour cells in all forms of CD30+ CLPD and CD30+ cell lines. However, no Bax expression was found in tumour cell lines derived from systemic CD30+ lymphomas, which lack spontaneous regression and display an aggressive clinical course. No significant correlation was found between the expression of apoptosis-related proteins and the tumour type and evolutional stage of CD30+ CLPD. We conclude that the higher AI in LyP may contribute to the regression of LyP lesions and the excellent prognosis of the disease. Pro-apoptotic protein Bax is expressed at high levels in CD30+ CLPD and may play a crucial role in mediating apoptosis of tumour cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.0906-6705.2005.00293.x
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  • 3
    Digitale Medien
    Digitale Medien
    Deep dermal burn injury results in scarless wound healing in the ovine fetus (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Early to mid-term fetuses heal cutaneous incisional wounds without scars; however, fetal response to burn injury has not been ascertained. We present a fetal model of thermal injury and subsequent analysis of fetal and lamb response to burn injury. A reproducible deep dermal burn injury was created in the fetus by application of water at 66 °C for 7 seconds, and at 82 °C for 10 seconds to the lamb. Macroscopically, the area of fetal scald was undetectable from day 7 post injury, while all lamb scalds were readily identified and eventually healed with scarring. Using a five-point histopathology scoring system for alteration in tissue morphology, differences were detected between control and scalded skin at all stages in lamb postburn, but no difference was detected in the fetal model after day 7. There were also large differences in content of α-smooth muscle actin and transforming growth factor-β1 between control and scalded lamb and these differences were statistically significant at day 14 (P 〈 0.01). This novel model of fetal and lamb response to deep dermal injury indicates that the fetus heals a deep burn injury in a scarless fashion. Further elucidation of this specific fetal process of burn injury repair may lead to improved outcome for patients with burn injury.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130210.x
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  • 4
    Digitale Medien
    Digitale Medien
    Collagen in the scarless fetal skin wound: Detection with Picrosirius-polarization (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Our group has developed an ovine model of deep dermal, partial-thickness burn where the fetus heals scarlessly and the lamb heals with scar. The comparison of collagen structure between these two different mechanisms of healing may elucidate the process of scarless wound healing. Picrosirius staining followed by polarized light microscopy was used to visualize collagen fibers, with digital capture and analysis. Collagen deposition increased with fetal age and the fibers became thicker, changing from green (type III collagen) to yellow/red (type I collagen). The ratio of type III collagen to type I was high in the fetus (166), whereas the lamb had a much lower ratio (0.2). After burn, the ratios of type III to type I collagen did not differ from those in control skin for either fetus or lamb. The fetal tissue maintained normal tissue architecture after burn while the lamb tissue showed irregular collagen organization. In conclusion, the type or amount of collagen does not alter significantly after injury. Tissue architecture differed between fetal and lamb tissue, suggesting that scar development is related to collagen cross-linking or arrangement. This study indicates that healing in the scarless fetal wound is representative of the normal fetal growth pattern, rather than a “response” to burn injury.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130211.x
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  • 5
    Digitale Medien
    Digitale Medien
    HLA-G expression in basal cell carcinomas of the skin recurring after radiotherapy (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 30 (2005), S. 0 
    Details
    ISSN: 1365-2230
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Basal cell carcinoma (BCC) of the skin represents the most common malignancy in the fair-skinned population worldwide. HLA-G is one of the molecules implicated in immunotolerance. To investigate the role of HLA-G in recurring BCCs, we constructed a tissue microarray containing 38 primary BCCs that underwent radiotherapy and 14 secondary BCCs recurring on the primary site after radiotherapy, and evaluated the HLA-G protein expression by immunohistochemistry. The HLA-G protein was most frequently expressed in aggressive sclerosing BCCs. Nodular BCC demonstrated the strongest HLA-G expression. Interestingly, tumor infiltrating mononuclear cells (TIMC) expressed the HLA-G molecule in BCCs that showed no recurrence. After comparing primary BCCs and BCCs relapsed after radiotherapy, we observed decreased HLA-G expression on tumor cells and the loss of HLA-G expression on TIMC in relapsed BCCs. After radiotherapy, immunobiology of BCC may change resulting in the down-regulation of HLA-G expression on tumor and on tumor-infiltrating cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2230.2005.01790.x
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  • 6
    Digitale Medien
    Digitale Medien
    DNA array analysis of Candida albicans gene expression in response to adherence to polystyrene (2005)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 245 (2005), S. 0 
    Details
    ISSN: 1574-6968
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: Candidiasis is often initiated by the colonization of inert surfaces. In order to elucidate the mechanisms involved in this adherence process, DNA macroarrays were used to analyze the transcriptome of Candida albicans, the main causative agent of this mycoses, in a simple adherence model using germ tubes produced in polystyrene Petri dishes. Non-adherent germ tubes produced on glass surface were used as a control. Analysis of gene expression displayed 77 genes identified as statistically overexpressed in adherent germ tubes. Among these genes, some encoded enzymes participating in metabolism of lipids (such as LIP6), of proteins (such as SAP1) or of carbohydrates (like PGI1, PMI40 and PSA1. Some of these genes have already been reported as playing a role in pathogenesis of C. albicans. However, functions were unknown for a large part (45.5%) of the overexpressed genes which will be analyzed further in order to define their relationship with adherence.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/j.femsle.2005.02.014
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  • 7
    Digitale Medien
    Digitale Medien
    Storage solutions in a co-operative library system: The case of Germany/Bavaria (2005)
    Bingley : Emerald
    Library management 26 (2005), S. 79-88 
    Details
    ISSN: 0143-5124
    Quelle: Emerald Fulltext Archive Database 1994-2005
    Thema: Buch- und Bibliothekswesen, Informationswissenschaft
    Notizen: Purpose - Aims to highlight how the complex issue of storage problems is managed within the context of German and Bavarian libraries. Design/methodology/approach - Introduces very briefly the main features of the German scholarly library system, focusing on the aspects of storage and archiving. Then, presents the characteristics and peculiarities of the repository concepts realized on the national and the regional level. For the latter, focuses on Bavaria, which provides perhaps the best example of a working co-ordinated regional archiving system. Findings - In Germany, establishing a repository library like those in the Scandinavian countries or in the Anglo-Saxon world seems impossible. In the last few years in the area of storage concepts there has been an avoidance of the idea of central and regional storage libraries. The few existing co-operative models (examples are to be found in the states of North Rhine Westphalia and Baden-Württemberg) have failed. In light of experiences thus far, the idea of a more or less self-sufficient, self-staffed and independently organized regional storage library must be viewed with scepticism. Originality/value - A storage library is, at least in Germany, currently only conceivable in the sense of a stacks enlargement project, or in the creation of an additional stacks location for an already existing and already archive-friendly library. The best example is Bavaria.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1108/01435120510572905
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  • 8
    Digitale Medien
    Digitale Medien
    Hypertext atlas of dermatopathology with expert system for epithelial tumors of the skin (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background:  Image resolution required for reference histological images is high. Obtaining high-resolution images requires a system, composing large image from individual smaller components. Such systems must thus be capable of automatically taking individual image parts, performing shading compensation and fusion of the image parts into one large image. Distribution of such images over the Internet requires developing a suitable user's interface with access to the image details.Methods:  The ways of creating high-resolution images (virtual slides) and the interface enabling access to image details using Internet browser are described.Results:  A collection of about 3200 dermatopathological, mostly histologic images is available at : Hypertext atlas of dermatopathology. Methods of high-resolution image acquisition were used in digitizing the collection of skin lymphomas (Dermatology Institute, University Hospital, Zurich), which is a part of the atlas. The atlas is continuously maintained and upgraded; the number of contributors is growing.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.00291.x
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  • 9
    Digitale Medien
    Digitale Medien
    WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract:  The new WHO/EORTC classification for cutaneous lymphomas comprises mature T-cell and natural killer (NK)-cell neoplasms, mature B-cell neoplasms, and immature hematopoietic malignancies. It reflects the unique features of lymphoproliferative diseases of the skin, and at the same time it is as compatible as possible with the concepts underlying the WHO classification for nodal lymphomas and the EORTC classification of cutaneous lymphomas. This article reviews the histological, phenotypical, and molecular genetic features of the various nosological entities included in this new classification. These findings always have to be interpreted in the context of the clinical features and biologic behavior.Aim:  To review the histological, phenotypical and molecular genetic features of the various nosological entities of the new WHO/EORTC classification for cutaneous lymphomas.Methods:  Extensive review of the literature cited in Medline and own data of the authors.Results:  The WHO/EORTC classification of cutaneous lymphomas comprises mature T-cell and NK-cell neoplasms, mature B-cell neoplasms and immature hematopoietic malignancies. It reflects the unique features of primary cutaneous lymphoproliferative diseases.Conclusion:  This classification is as much as possible compatible with the concept of the WHO classification for nodal lymphomas and the EORTC classification of cutaneous lymphomas. The histological, phenotypical and molecular genetic features always have to be interpreted in the context of the clinical features and biologic behavior.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.00495.x
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  • 10
    Digitale Medien
    Digitale Medien
    Investigations on Explanted Ceramic-Ceramic Couplings after Squeaking (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 396-398 (Oct. 2008), p. 149-152 
    Details
    ISSN: 1013-9826
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: In the present investigation, three ceramic-ceramic-couplings (alumina - alumina) were examined for possible reasons of the squeaking noise which occurred after surgery. Under certain conditions like, for example, a suboptimal position of the implant and corresponding soft tissue relations, a subluxation or microseparation of the ceramic head from the ceramic liner may occur; this, in turn, may lead to a squeaking noise of the joint. Apart from the psychological stress for the patient due to the awkward noise and the resulting feeling of instability, the squeaking noise is a sign for damages on the implant in most cases
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/57/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.396-398.149.pdf
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