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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing
    The @journal of child psychology and psychiatry 46 (2005), S. 0 
    ISSN: 1469-7610
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Background:  Associations between early mother–child mutually responsive orientation (MRO) and children's conscience have been previously established, but the mechanisms accounting for those links are not understood. We examined three such mediational mechanisms: (a) the child's enhanced enjoyment of interactions with the mother, (b) increased committed, self-regulated compliance with the mother, and/or (c) a decreased need for maternal use of power assertion. Children's conscience was seen as a complex system encompassing moral emotion (guilt), conduct, and cognition.Methods:  In a longitudinal design, MRO was observed in mothers’ and children's multiple naturalistic interactions at 9, 14, and 22 months. The mediators were observed at 33 months. Children's conscience was observed at 45 months (moral emotion) and at 56 months (moral conduct and cognition).Results:  The mediating paths were different for the three components of conscience. MRO had a direct, unmediated effect on moral emotion. MRO influenced moral conduct through two mediational paths: by promoting the child's enjoyment of interactions with the mother and by enhancing committed compliance. MRO influenced moral cognition by promoting the child's enjoyment of mother–child interactions. Maternal power assertion did not mediate the relation between MRO and conscience once the influence of the other mediators was considered.Conclusions:  The impact of the early mother–child relationship on future conscience appears to be a complex process that progresses along distinct paths.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Burkholderia pseudomallei and B. mallei are the causative agents of melioidosis and glanders, respectively. As iron regulation of gene expression is common in bacteria, in the present studies, we have used microarray analysis to examine the effects of growth in different iron concentrations on the regulation of gene expression in B. pseudomallei and B. mallei. Gene expression profiles for these two bacterial species were similar under high and low iron growth conditions irrespective of growth phase. Growth in low iron led to reduced expression of genes encoding most respiratory metabolic systems and proteins of putative function, such as NADH-dehydrogenases, cytochrome oxidases, and ATP-synthases. In contrast, genes encoding siderophore-mediated iron transport, heme-hemin receptors, and a variety of metabolic enzymes for alternative metabolism were induced under low iron conditions. The overall gene expression profiles suggest that B. pseudomallei and B. mallei are able to adapt to the iron-restricted conditions in the host environment by up-regulating an iron-acquisition system and by using alternative metabolic pathways for energy production. The observations relative to the induction of specific metabolic enzymes during bacterial growth under low iron conditions warrants further experimentation.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Sedimentology 52 (2005), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: The concept of the wave-graded continental shelf, with sea floor sediment coarsening from offshore mud to shoreface sand, has been well known from the time of Johnson (1919). Although most of the modern shelf shows textures unrelated to water depth on account of relict features or sediment starvation, the geological record is more likely to preserve sites where sediment is being fed to a subsiding inner-shelf. These consistently show the landward-coarsening pattern of the wave-graded shelf, recording past water depth history in accumulated sea floor sediment. The landward-coarsening pattern is driven primarily by wave-induced bed shear stress, which increases shoreward exponentially, although it also varies from place to place with wave climate, and can be influenced by sediment concentration and currents. In this study, the relationship between bed shear stress, sediment texture and water depth has been investigated by comparing per cent mud and wave climate data from shore-normal transects of three modern wave-graded coastal settings: Wellington Harbour (low energy) and the Manawatu coast (moderate energy) in New Zealand, and Monterey Bay in California (moderate–high energy). Samples from all three locations show a progressive change from poorly sorted mud offshore to well-sorted fine sand nearshore, with the sand–mud transition ranging from 3 m (low energy) to 50 m (moderate–high energy), reflecting differences in average bed shear. Repeat measurements of per cent mud on seasonal, annual and decadal time scales along a Manawatu coastal transect showed no measurable change, demonstrating equilibrium between sediment supply, wave energy, water depth and sediment texture. A simple model based on the relationship between wave climate, shear stress and per cent mud, and using data and conditions from the modern Manawatu coast, is applied to two mid-Pliocene cyclothems exposed 50 km inland, giving results comparable with estimates from foraminifera and the deep-sea isotope record. Per cent mud offers more detail for palaeobathymetric trends in shallow water shelf strata than other proxy depth recorders, although it is limited to depths above wave base and requires an independent estimate of wave climate if depths are to be quantified.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Gene transfer into hematopoietic stem cells has been used successfully for correcting lymphoid but not myeloid immunodeficiencies. Here we report on two adults who received gene therapy after nonmyeloablative bone marrow conditioning for the treatment of X-linked chronic granulomatous disease ...
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Methylmalonic aciduria and homocystinuria, cblC type (OMIM 277400), is the most common inborn error of vitamin B12 (cobalamin) metabolism, with about 250 known cases. Affected individuals have developmental, hematological, neurological, metabolic, ophthalmologic and dermatologic clinical findings. ...
    Type of Medium: Electronic Resource
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