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  • 2005-2009  (90)
  • 1
    Electronic Resource
    Electronic Resource
    Microbial Contamination and Associated Corrosion in Fuels, during Storage, Distribution and Use (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Advanced materials research Vol. 38 (Mar. 2008), p. 257-268 
    Details
    ISSN: 1662-8985
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Microbial contamination and growth in distillate fuels has been described for seventyyears. The consequences have ranged from fouling of filters and injectors, to engine malfunctionand damage, fuel gauge malfunctions and aggravated corrosion of engines, fuel tanks, equipmentand facilities. The types of microbes present vary with the differences in fuel composition anddifferences in storage and use conditions. Anti-microbial strategies have traditionally includedprevention by ‘good housekeeping’ and ‘fire-brigade’ applications of biocides when there areoperational problems. Since 2002, first the aviation industry and later fuel suppliers and somemilitaries, have used simple on-site microbiological tests to monitor fuel and fuel systems and usethe results to take remedial actions before operational problems occur. This paper will review ourlatest knowledge of microbially influenced corrosion and of the new anti-microbial strategies whichare being successfully implemented to prevent it
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/40/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.38.257.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Initial report of the use of an injectable porcine collagen-derived matrix to stimulate healing of diabetic foot wounds in humans (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A novel injectable scaffolding matrix (E-Matrix™) has been developed to accelerate wound healing in diabetic foot ulcers. This porcine collagen-derived matrix is designed to mimic tertiary embryonic connective tissue and to stimulate fetal wound repair mechanisms including angiogenesis. In vitro and animal studies have indicated a beneficial effect on tissue growth and an acceptable safety profile. In this report, we describe the initial use of this product in a pilot study of six humans with chronic nonhealing diabetic foot ulcers. A dramatic initial response to injection was seen, with an average wound size reduction of 72% 2 weeks after injection. Randomized trials are underway to define the potential benefit of this new treatment modality for diabetic foot ulcers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130305.x
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  • 3
    Electronic Resource
    Electronic Resource
    033
A Pilot Randomized Study of the Treatment of Diabetic Foot Ulcers with a Bioactive CoPolymer, E-Matrix (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A novel biopolymer composed of porcine gelatin and dextran was used in a randomized controlled pilot clinical trial to treat diabetic foot ulcers to establish safety profile and evaluate effect on wound closure. Fifty-six patients were prospectively randomized at 10 centers (control = 25; E-Matrix = 31). Control patients received routine sharp debridement, off-loading, and hydrogel dressings applied daily. E-Matrix patients received identical wound care with the addition of monthly subcutaneous injections of E-Matrix under the wound surface. Patients were monitored for 12 weeks using wound planimetry and photography. Primary endpoint was safety as measured by adverse event reporting and clinical laboratory analysis. Secondary endpoint was wound closure based on intent to treat.There was no significant difference in the rate of adverse events between treated and control subjects. Overall closure rate for E-Matrix treated wounds was 42%(13 of 31 subjects) compared to 32%(8 of 25 subjects) for controls. Subgroup analysis suggested that E-Matrix may be more effective than control for treatment of larger (〉2 cm2) and older (〉17 weeks duration) wounds (see table).〈table frame="topbot"〉〈tgroup cols="5" align="left"〉〈colspec colnum="1" colname="col1" align="left"/〉〈colspec colnum="2" colname="col2" align="left"/〉〈colspec colnum="3" colname="col3" align="center"/〉〈colspec colnum="4" colname="col4" align="center"/〉〈colspec colnum="5" colname="col5" align="center"/〉〈thead valign="bottom"〉〈row rowsep="1"〉ParameterTreatment GroupNClosed%Closed〈tbody valign="top"〉Size 〉2 cmE-Matrix17847%Control14429%Ulcer duration 〉17 weeksE-Matrix15640%Control15320% Although the study is insufficiently powered to evaluate statistical significance, E-Matrix demonstrated a similar safety profile to control treatment with trends toward improved healing in larger and older wounds. Further randomized trials are necessary to confirm these promising initial results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130215ag.x
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  • 4
    Electronic Resource
    Electronic Resource
    Determination of Troponin I Release After CABG Surgery (2005)
    350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc
    Journal of cardiac surgery 20 (2005), S. 0 
    Details
    ISSN: 1540-8191
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  Background: Troponin I is used to diagnose myocardial infarction (MI). Its use and pattern of elevation is not well defined in coronary artery bypass graft (CABG) surgery. This study assessed the timing of troponin I elevation in patients undergoing urgent CABG. Method: Patients undergoing urgent isolated-CABG with cardiopulmonary bypass were studied prospectively. Blood samples were taken to measure CK, CK-MB, and troponin I: preoperatively, 7 hours postoperatively, 14 to 18 hours postoperatively, 30 to 48 hours postoperatively, and on postoperative day 4. Electrocardiograms and in-hospital course were recorded. Perioperative MI (PMI) was defined by either (i) ECG criteria of new Q-waves in the presence of CK-MB elevation 〉50 μg/L or (ii) CK-MB 〉 100 μg/L. Results: Of the 50 patients studied, 6 met the criteria for PMI (12%); 2 by criteria (i) and 4 by criteria (ii). In patients not meeting the criteria for MI the troponin I level peaked at 7 hour post-op with a mean of 20.97 μg/L (95% CI, 17.11 to 24.83). At this time, patients who met the criteria for MI had a mean troponin I level of 46.85 μg/L (95% CI, 36.40 to 57.30). Of variables investigated for the 44 patients who did not meet MI criteria, only preoperative troponin I level impacted peak postoperative troponin I. Conclusions: CABG elevates troponin I far beyond current diagnostic benchmarks without the clinical occurrence of a MI and appears to peak during the second postoperative day. An elevated preoperative troponin I may predict an elevated peak postoperative troponin I in patients who do not have a PMI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0886-0440.2005.200387.x
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  • 5
    Electronic Resource
    Electronic Resource
    Magnetocardiography Predicts Coronary Artery Disease in Patients with Acute Chest Pain (2005)
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2XG , UK . : Blackwell Publishing, Inc.
    Annals of noninvasive electrocardiology 10 (2005), S. 0 
    Details
    ISSN: 1542-474X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: The value of magnetocardiography (MCG) for the detection of cardiac electrical disturbances associated with myocardial ischemia was studied. Methods: Sensitivity and predictivity of admission MCG for the presence of coronary artery disease (CAD) were prospectively evaluated in 264 consecutive patients presenting with acute chest pain and without ST-segment elevation. MCG findings were compared with 12-lead ECG, echocardiography (ECHO), and troponin-I in a head-to-head design. Coronary angiography was used for CAD diagnosis. Results: The visual assessment of magnetocardiograms by the experienced reader (R1) was superior to that by the unexperienced reader (R2) and superior to the automated computer analysis. Specificity and positive predictive value of MCG by R1 were comparable with those of ECG and troponin-I (〉90%), while ECHO specificity and ECHO positive predictive value were lower (76.2% and 87.9%, respectively). Sensitivity and negative predictive value of MCG were twice as high as those in the ECG, troponin-I, and ECHO tests. Conclusion: For the prediction of CAD in patients presenting with acute chest pain and without ST-segment elevation, an admission MCG test was superior to an admission ECG, ECHO, and troponin-I. The results of the study, however, are applicable only to a highly selected population comprising patients in whom immediate coronary angiography can be performed based on their clinical course in the hospital.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1542-474X.2005.00634.x
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  • 6
    Electronic Resource
    Electronic Resource
    Magnetocardiogram Recordings in a Nonshielded Environment—Reproducibility and Ischemia Detection (2005)
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2XG , UK . : Blackwell Publishing, Inc.
    Annals of noninvasive electrocardiology 10 (2005), S. 0 
    Details
    ISSN: 1542-474X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Magnetocardiography (MCG) is a noninvasive technology that measures the magnetic field of the heart by superconducting quantum interference devices (SQUID) sensors. The novelty of the present system is that the sensors can be operated without electromagnetic shielding of the examination room, thus allowing the system to be easily installed in the emergency department or chest pain unit. Studies in shielded rooms, found that this imaging modality may have better sensitivity as compared to ECG in detecting ischemia. We aimed (1) to assess the reproducibility, intra-observer, and interobserver interpretation variability and (2) to assess the MCG maps in the presence of coronary narrowings. Methods and Results: All measurements were performed in a nonshielded room. For the first part of the study, two MCG maps were recorded in 24 otherwise healthy volunteers (age 20–44 years, median 24, 16 male) in an interval ranging from 2 to 48 hours. The maps were interpreted using the CardioMag software for contour maps, averaged MCG time traces, and waveform morphology of repolarization by two observers blinded to each other. The parameters tested had low disagreement between repeated measurements. The correlations of the intra-observer and interobserver interpretation were excellent. Secondly, MCG maps were obtained in 29 patients referred for angiography due to suspected coronary artery disease. Nineteen of them had coronary narrowings defined as more than 50%. In this group, 16 (84.2%) had abnormal MCG maps as compared to only 5 (26.3%) who had abnormal ECGs (P 〈 0.01). Conclusions: MCG maps can be successfully obtained in a nonshielded room and allow feasible, accurate, and reproducible measurements with little intra-observer and interobserver variability. Ischemic changes in the heart's magnetic field may occur before electrical changes. Our pilot data suggests that this imaging modality may potentially offer better sensitivity as compared to rest ECG in detecting ischemia in a cohort of patients who had coronary narrowings identified by angiography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1542-474X.2005.05611.x
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  • 7
    Electronic Resource
    Electronic Resource
    Evaporation-Assisted Formation of Three-Dimensional Photonic Crystals (2005)
    Oxford, UK : Blackwell Science Inc
    Journal of the American Ceramic Society 88 (2005), S. 0 
    Details
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The process of evaporation-assisted formation of three-dimensional photonic crystals was studied. The photonic crystals were fabricated by stacking uniform-sized silica spheres into regularly arranged structure with solvent evaporation and sedimentation. Effects of important process parameters, including type of solvent (water and ethanol), system temperature (40° and 60°C), and material for sedimentation cell (quartz, polymethyl methacrylate, and Teflon), on structure regularity of the resulting photonic crystal were investigated. The structure regularity was evaluated with scanning electron microscope graphs and stop band depth achieved in optical absorption spectra. As revealed from the experimental results, photonic crystals of better quality were obtained by using suspending solvents of higher surface tension (water), lower system temperatures (40°C), and sedimentation cell materials of higher critical surface tension of wetting (quartz).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1551-2916.2005.00153.x
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  • 8
    Electronic Resource
    Electronic Resource
    Through the Past Darkly: A Review of the British Ability Scales Second Edition (2005)
    Oxford, UK : Blackwell Publishing Limited
    Child and adolescent mental health 10 (2005), S. 0 
    Details
    ISSN: 1475-3588
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Notes: This article provides a review of the British Ability Scales, Second Edition (BAS II) for applied psychologists; it aims to describe the special features of the scale, highlighting implications for practice, as well as describing the developments in psychometry this scale represents in comparison with other widely used tests. Although the BAS has been in use since 1979 and represents a more contemporary psychometric model of human ability, with British norms, it is not as widely used in British research or applied psychological assessment as might be anticipated; traditional allegiances to the older, more established, Anglicised standardisation of the American Wechsler scales appear to persist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1475-3588.2004.00123.x
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  • 9
    Electronic Resource
    Electronic Resource
    Prion protein glycosylation (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 93 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The transmissible spongiform encephalopathies (TSE), or prion diseases are a group of transmissible neurodegenerative disorders of humans and animals. Although the infectious agent (the ‘prion’) has not yet been formally defined at the molecular level, much evidence exists to suggest that the major or sole component is an abnormal isoform of the host encoded prion protein (PrP). Different strains or isolates of the infectious agent exist, which exhibit characteristic disease phenotypes when transmitted to susceptible animals. In the absence of a nucleic acid genome it has been hard to accommodate the existence of TSE strains within the protein-only model of prion replication. Recent work examining the conformation and glycosylation patterns of disease-associated PrP has shown that these post-translational modifications show strain-specific properties and contribute to the molecular basis of TSE strain variation. This article will review the role of glycosylation in the susceptibility of cellular PrP to conversion to the disease-associated conformation and the role of glycosylation as a marker of TSE strain type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.03104.x
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  • 10
    Electronic Resource
    Electronic Resource
    Synapse associated protein 102 is a novel binding partner to the cytoplasmic terminus of neurone-glial related cell adhesion molecule (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 94 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Neurone glial-related cell adhesion molecule (NrCAM) is a member of the L1 family of transmembrane cell adhesion receptors which are involved in the development and function of the mammalian nervous system. How these receptors interact with intracellular signalling pathways is not understood. To date the only identified binding partner to the cytoplasmic terminus of NrCAM is ankyrin G. We screened a developing rat brain cDNA yeast two-hybrid library with the cytoplasmic domain of NrCAM to identify further intracellular binding partners. We identified synapse associated protein 102 (SAP102) as a new binding partner for NrCAM. The interaction was confirmed biochemically using glutathione S-transferase (GST)-pull-down and tandem affinity purification, and also immunocytochemically as NrCAM and SAP102 co-localized in COS-7 and cerebellar granule cells. Binding was specific to NrCAM as neither neurofascin nor L1 bound SAP102, and this interaction was reliant on the last three amino acids of NrCAM. Additionally, NrCAM constructs whose last three amino acids had been deleted appeared to have a dominant negative effect on neurite extension of cerebellar granule cells. This is the first interaction reported for NrCAM, and its association with SAP102 suggests that it is part of a larger complex which can interact with many different signalling pathways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.03271.x
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