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  • 2005-2009  (25)
  • 1
    Electronic Resource
    Electronic Resource
    Do People Value Racial Diversity? Evidence from Nielsen Ratings (2005)
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Topics in economic analysis & policy 5.2005, 1, art4 
    Details
    ISSN: 1538-0653
    Source: Berkeley Electronic Press Academic Journals
    Topics: Economics
    Notes: Nielsen ratings for ABC's Monday Night Football are significantly higher when the game involves a black quarterback. In this paper, we consider competing explanations for this effect. First, quarterback race might proxy for other player or team attributes. Second, black viewership patterns might be sensitive to quarterback race. Third, viewers of all races might be exhibiting a taste for diversity. We use both ratings data and evidence on racial attitudes from the General Social Survey to test these hypotheses empirically. The evidence strongly supports the taste-for-diversity hypothesis, while suggesting some role for black own-race preferences as well.
    Type of Medium: Electronic Resource
    URL: http://www.bepress.com/bejeap/topics/vol5/iss1/art4
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Aging and Future Healthcare Expenditure: A Consistent Approach (2007)
    Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)
    Forum for health economics & policy 10 (2007), S. 1 
    Details
    ISSN: 1558-9544
    Source: Berkeley Electronic Press Academic Journals
    Topics: Medicine , Economics
    Notes: The impact of aging on healthcare expenditure (HCE) has been at the center of a prolonged debate. This paper purports to shed light on several issues of this debate by presenting new evidence on the "red herring" hypothesis advanced by Zweifel, Felder and Meier (1999). This hypothesis amounts to distinguishing a mortality from a morbidity component in healthcare expenditure (HCE) and claiming that failure to make this distinction results in excessive estimates of future growth of HCE. A re-estimation based on a much larger data set is performed, using the refined econometric methodology. The main contribution is consistency, however. Rather than treating the mortality component as a residual in forecasting, its dynamics are analyzed in the same detail as that of the morbidity component when predicting the impact of population aging on the future growth of HCE. For the case of Switzerland, it finds this impact to be relatively small regardless of whether or not the mortality component is accounted for, thus qualifying the "red herring" hypothesis.
    Type of Medium: Electronic Resource
    URL: http://www.bepress.com/fhep/10/2/1
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Expression of androgen receptor coactivator ARA70/ELE1 in androgenic alopecia (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Androgens have been implicated in androgenic alopecia as evidenced by the increased cutaneous expression of androgen receptor (AR), 5α-reductase, and decreased aromatase. Abnormalities of the AR-signal transduction pathway probably participate in the development of androgenic alopecia. ARA70/ELE1 is an AR coactivator with two isoforms, one full-length form (ARA70α/ELE1α), and an internally deleted form (ARA70β/ELE1β). We decided to examine the cutaneous expression of both isoforms in male androgenic alopecia.Methods:  Formalin-fixed, paraffin-embedded tissue sections from seven subjects with androgenic alopecia with matched punch biopsies from non-balding and balding areas were examined by in situ hybridization.Results:  Expression of at least one of the two probes for ARA70/ELE1 was present in all phases of the hair-growth cycle in all epithelial hair structures except for the inner root sheath. The dermal papilla and hair bulb expressed only the short (β) but not the long (α) form of ARA70/ELE1. In situ labeling for ARA70β/ELE1β was weaker in the dermal papilla of balding recipient areas than those from donor ones.Conclusions:  Our data further support that the hair growth is regulated by androgens. The differential expression pattern of ARA70/ELE1 suggests that this key androgen receptor coactivator is involved in androgenic alopecia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.00397.x
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  • 4
    Electronic Resource
    Electronic Resource
    Loss of claudin-1 expression in tumor-associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  Claudins are a family of transmembrane proteins involved in cell-to-cell adhesion and are believed to be the main component of tight junctions. Recent studies have suggested that some metastatic solid tumors lack claudin expression. It is unknown whether claudins play a role in cutaneous melanoma. Immunohistochemical studies were performed on tissue microarrays containing 19 benign melanocytic nevi (BN), 21 dysplastic nevi (DN), 23 primary malignant melanomas (MMs), and 31 metastatic melanomas (MMMs) using a polyclonal anti-claudin-1 antibody. Immunoreactivity in tumor cells and associated vessels was graded by intensity and by percentage of reactive cells. Normal epidermis served as internal control (3+ labeling). Cases with at least 2+ labeling in more than 25% of the cells were considered positive. Claudin-1 expression was present in 37% of BN, 24% of DN, 26% of MM, and 3.2% of MMM. Tumor-associated vessels showed the following results: 11 of 19 (58%) in BN, 14 of 21 (67%) in DN, 17 of 23 (74%) in MM, and 6 of 31 (19%) in MMM. A significant loss of expression was noted between MMM and all other lesions in tumor cells and associated vessels. There was no significant difference between BN, DN, and MM. Within primary melanomas, there was a significant correlation between expression of claudin in tumor cells and Clark level/Breslow thickness. Also significant was a decreased expression of claudin in tumor vessels of lesions with higher Breslow thickness or Clark level. These data suggest that loss of claudin-1 may play a significant role in the acquisition of metastatic phenotype in cutaneous melanoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.00324.x
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  • 5
    Electronic Resource
    Electronic Resource
    BOOK REVIEWS (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 67 (2005), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-1112.2005.00827.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Does biogeographical history matter? Diversity and distribution of lotic midges (Diptera: Chironomidae) in the Australian Wet Tropics (2005)
    Oxford, UK : Blackwell Science Pty
    Austral ecology 30 (2005), S. 0 
    Details
    ISSN: 1442-9993
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract  We examined broad scale patterns of diversity and distribution of lotic Chironomidae (Diptera) within the Wet Tropics bioregion of northern Queensland, Australia. Field surveys across broad latitudinal and altitudinal gradients within the Wet Tropics revealed a fauna of 87 species-level taxa in 49 genera comprising three main elements: a small genuinely tropical fraction, and larger cosmopolitan and Gondwanan components. The latter group originated when Australia, as part of the ancient Gondwana supercontinent, was situated over Antarctic latitudes with a cooler, wetter climate than today. In the Wet Tropics, cool Gondwanan taxa occurred predominantly in upland and shaded lowland sites, but no species appeared narrowly temperature restricted, and there was no faunal zonation with altitude. Most chironomid species occurred at all latitudes within the Wet Tropics, with no evidence for an enduring effect of the historical rainforest contractions on current-day distribution patterns. These findings contrast with those for aquatic faunas elsewhere in the world and for the terrestrial Wet Tropics fauna. We relate this to the generally broad environmental tolerances of Australian chironomids, and comment on why the latitudinal diversity gradient does not apply to the Australian chironomid fauna.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1442-9993.2005.01408.x
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  • 7
    Electronic Resource
    Electronic Resource
    Reply to 'Truth in Numbers' (2006)
    [s.l.] : Nature Publishing Group
    Nature medicine 12 (2006), S. 269-269 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] To the editor: Merck is committed to the highest standards of scientific integrity and patient safety. Your editorial “Truth in Numbers” (January 2006) incorrectly characterizes how we disclosed information regarding the VIGOR study. I am writing to set the record straight. As we have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0306-269a
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  • 8
    Electronic Resource
    Electronic Resource
    Mitochondrial point mutations do not limit the natural lifespan of mice (2007)
    [s.l.] : Nature Publishing Group
    Nature genetics 39 (2007), S. 540-543 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Whether mitochondrial mutations cause mammalian aging, or are merely correlated with it, is an area of intense debate. Here, we use a new, highly sensitive assay to redefine the relationship between mitochondrial mutations and age. We measured the in vivo rate of change of the mitochondrial genome ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1988
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  • 9
    Electronic Resource
    Electronic Resource
    The roles of MAD1 , MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes (2005)
    [s.l.] : Nature Publishing Group
    Nature genetics 37 (2005), S. 756-760 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Errors in meiotic chromosome segregation are the leading cause of spontaneous abortions and birth defects. In humans, chromosomes that fail to experience crossovers (or exchanges) are error-prone, more likely than exchange chromosomes to mis-segregate in meiosis. We used a yeast model to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1588
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  • 10
    Electronic Resource
    Electronic Resource
    Emergence of a new disease as a result of interspecific virulence gene transfer (2006)
    [s.l.] : Nature Publishing Group
    Nature genetics 38 (2006), S. 953-956 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] New diseases of humans, animals and plants emerge regularly. Enhanced virulence on a new host can be facilitated by the acquisition of novel virulence factors. Interspecific gene transfer is known to be a source of such virulence factors in bacterial pathogens (often manifested as pathogenicity ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1839
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