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  • 1
    Electronic Resource
    Electronic Resource
    A mutation (Trp1193→Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance (1993)
    Springer
    Diabetologia 36 (1993), S. 414-422 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptor ; mutation ; tyrosine kinase activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We evaluated a 35-year-old diabetic male patient with type A insulin resistance, showing acanthosis nigricans. Insulin binding to the patient's Epstein-Barr-virus transformed lymphocytes was mildly reduced. The maximal insulin-stimulated autophosphorylation of the insulin receptor from the patient's transformed lymphocytes was decreased to 45% of that from the control subjects. On examination, the biological activities of insulin and insulin-like growth factor I in the patient's cultured fibroblasts, insulin sensitivity of amino isobutyric acid uptake and thymidine incorporation was decreased, but insulin-like growth factor I action was normal. The sequence analysis of amplified genomic DNA revealed that the patient was heterozygous for a mutation substituting Leu for Trp at codon 1193 in exon 20 of the insulin receptor gene. The patient's mother and sister were also heterozygous for a mutation in the insulin receptor gene that substituted Leu for Trp1193 in the Β subunit of the receptor. Therefore, the mutation causes insulin resistance in a dominant fashion. They were less hyperglycaemic and more hyperinsulinaemic than the proband after glucose loading. The mother had diabetes mellitus but did not show acanthosis nigricans, while the sister did not have diabetes and showed acanthosis nigricans. These results suggest that this mutation causes defective tyrosine kinase activity of the insulin receptor, which results in insulin resistance. Insulin action and phenotypic appearance may be mediated by different factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402277
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  • 2
    Electronic Resource
    Electronic Resource
    Nonoxidative protein glycation is implicated in familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation (2000)
    Springer
    Acta neuropathologica 100 (2000), S. 275-284 
    Details
    ISSN: 1432-0533
    Keywords: Key words Amyotrophic lateral sclerosis ; Imidazolone ; Nɛ-carboxymethyl-lysine ; Pyrraline ; Superoxide dismutase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess a role for oxidative stress in the pathogenesis of amyotrophic lateral sclerosis (ALS), we analyzed the immunohistochemical localization of 8-hydroxy-2′-deoxyguanosine (OHdG) as a nucleic acid oxidation product, acrolein-protein adduct and 4-hydroxy-2-nonenal (HNE)-protein adduct as lipid peroxidation products, N ɛ-carboxymethyl-lysine (CML) as a lipid peroxidation or protein glycoxidation product, pentosidine as a protein glycoxidation product, and imidazolone and pyrraline as nonoxidative protein glycation products in the spinal cord of three familial ALS patients with superoxide dismutase-1 (SOD1) A4V mutation, six sporadic ALS patients, and six age-matched control individuals. The spinal cord sections of the control cases did not show any distinct immunoreactivities for these examined products. In the familial ALS cases, intense immunoreactivities for pyrraline and CML were confined to the characteristic Lewy body-like hyaline inclusions, and imidazolone immunoreactivity was located in the cytoplasm of the residual motor neurons. No significant immunoreactivities for other examined products were detected in the familial ALS spinal cords. In the sporadic ALS cases, intense immunoreactivities for pentosidine, CML and HNE-protein adduct were seen in the cytoplasm of the degenerated motor neurons, and OHdG immunoreactivity was located in the cell nuclei of the residual neurons and glial cells. The present results indicate that oxidative reactions are involved in the disease processes of sporadic ALS, while there is no evidence for increased oxidative damage except for CML deposition in the familial ALS spinal cords. Furthermore, it is likely that the accumulation of pyrraline and imidazolone supports a nonoxidative mechanism in SOD1-related motor neuron degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004019900173
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  • 3
    Electronic Resource
    Electronic Resource
    Indole-inducible proteins in bacteria suggest membrane and oxidant toxicity (2000)
    Springer
    Archives of microbiology 173 (2000), S. 78-82 
    Details
    ISSN: 1432-072X
    Keywords: Key words Tetralin ; Cumene hydroperoxide ; Cpx ¶regulon ; Membrane adhesion sites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Oxidant toxicity of indole was demonstrated by the induction of alkylhydroperoxide reductase subunit C (AhpC) in Escherichia coli K12 and by the constitutive overproduction of AhpC in a variant of E. coli JM109 with enhanced resistance to indole. Oxidant toxicity was also indicated in an indole-adapted variant of Brevibacterium flavum by the indole-inducible overproduction of a novel 36-kDa protein with N-terminal sequence similarity to proteins involved in superoxide and singlet oxygen resistance. It is proposed that indole dissolved in membrane lipids, which caused membrane derangement and enabled direct interaction of redox-cycling isoprenoid quinones and dioxygen, resulting in the generation of superoxide. ¶A direct indication of membrane derangement in E. coli may be the indole-inducible overproduction of spheroplast protein y (Spy).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002030050012
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  • 4
    Electronic Resource
    Electronic Resource
    Short stature with normal growth hormone and elevated IGF-I (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 321-325 
    Details
    ISSN: 1432-1076
    Keywords: Short stature ; Somatomedin-C ; IGF-I ; IGF-I resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report on a Japanese girl with short stature, malar hypoplasia, up-slanting palpebral fissures, blue sclerae and thin, stiff and slightly brownish hair. Short stature started in utero and her psychomotor development was normal. Menarche appeared at 13 years 8 months. Height at 14 years 5 months was 132 cm (−4.6 SD). Her growth hormone (GH) sleep pattern and responses to insulin,l-dopa, arginine, propranolol-glucagon and growth hormone-releasing hormone were normal. Plasma insulin-like growth factor I (IGF-I) was high (2170–4860 units/l) and increased from 4860 to 7080 units/l 20 h after biosynthetic GH injection. Gel infiltration patterns of the free and protein-bound IGF-I in plasma from the patient were not different from the controls; IGF-I fraction of the high and low molecular weight binding protein and the non-protein bound fraction were 75.5%, 15.8% and 8.7%, respectively. IGF-I from the patient showed normal bioactivities when determined by [35S]sulphate and [3H]thymidine uptake into cultured rat chondrocytes, and by [3H]thymidine and [3H]α-aminoisobutyric acid uptake into the patient's skin fibroblasts. IGF-I binding to cultured skin fibroblasts from the patient was comparable to that of controls. These results suggest that tissue specific defects of IGF-I receptors may be the cause of increased IGF-I levels in the patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113248
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  • 5
    Electronic Resource
    Electronic Resource
    Superplasticity of Fine TiC and TiN Dispersed Ti-6Al-4V Alloy Composites (1994)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 170-172 (Oct. 1994), p. 549-554 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/00/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.170-172.549.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols (1991)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 77 (1991), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The antiviral extract from Rhodopseudomonas capsulata was purified and the predominant active component was defined as cis-vaccenic acid (C1- 8:1 Δ11) by gas-liquid chromatography and gas chromatography-mass spectrometry analyses. Antiviral activities of unsaturated fatty acids and related alcohols against T5 phage were also tested. Among them, linoelaidic acid, oleic acid, and petroselenyl alcohol inactivated 98%, 53%, 67% of T5 phage at the concentration of 50 μ g/ml, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1991.tb04314.x
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  • 7
    Electronic Resource
    Electronic Resource
    Frequency dependence of tokamak plasma response to the externally applied rotating helical field (2000)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 7 (2000), S. 3288-3300 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The frequency dependence of the tokamak plasma response to the externally applied rotating helical field was investigated by measuring the radial profile of the perturbation field with small magnetic probes which were inserted in the plasma. The experimental results are discussed, directly comparing with the generally accepted linear theory, and taking into account the E×B drift and diamagnetic effect of the plasma. It was found that the experimental results are in good agreement with the simple linear analysis based on the single helicity approximation in a cylindrical geometry, except for the ergodic region, which comes from the overlapping of several sideband components of the perturbation. It is also found that the radial component of the perturbation field is still amplified inside the resonance surface (r〈rs), even when a partial shielding takes place at r(approximate)rs. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.874194
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  • 8
    Electronic Resource
    Electronic Resource
    Electrostatic fluctuations in the Current Sustained Torus IV at Nagoya University (2000)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 7 (2000), S. 2449-2455 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A detailed experimental investigation of plasma fluctuation and its modification due to radial electric field effects, both its shear and curvature, has been carried out on the Current Sustained Torus IV at Nagoya University [Takamura et al., J. Plasma Fusion Res. 74, 38 (1998)] through measurement with an array of Langmuir probes. The observed statistical dispersion relation indicates a drift-wave-type turbulence. An examination of the radial electric field shear and curvature effects on the fluctuations as well as comparisons to theoretical predictions are presented. The decorrelation of turbulence is found to be influenced by the radial electric field shear in our experiment. A modification of the poloidal correlation length and the two-poloidal-point coherency due to the radial electric field has also been identified. Nonlinear analysis of quadratic mode coupling indicates that the radial electric field can affect the fluctuation amplitudes by modifying the coupling between different spectral components of the fluctuations. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.874084
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  • 9
    Electronic Resource
    Electronic Resource
    Immunomodulatory effects on rainbow trout, Oncorlynchus mykiss, injected with the extract of abalone, Haliotis discus hannai (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of applied ichthyology 7 (1991), S. 0 
    Details
    ISSN: 1439-0426
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Rainbow trout, Oncorhynchus mykiss, injected with a water fraction extracted from abalone, Haliotis discus hannai, showed enhanced phagocytosis. This enhanced activity reached its maximum level 5 days after injection. The natural killer cell activities and the chemiluminescence responses of kidney leukocytes in fish treated with this fraction were also significantly increased, compared to those in albumin-treated fish. Rainbow trout injected intraperitoneally with this fraction showed an increased resistance to Vibrio anguillarum.〈section xml:id="abs1-2"〉〈title type="main"〉Zusammenfassung Immunomodulationseffekte bei Regenbogenforellen, Oncorhynchus mykiss, nach Injektion von Aba-lone-Entrakt, Haliotis discus hannaiBei Regenbogenforellen, Oncorynchus mykiss, denen ein wäßriger Extrakt der Abalone, Haliotis discus hannai, injiziert wurde, konnte eine gesteigerte Phagocytoseaktivität beobachtet werden. Diese Aktivi-tätssteigerung erreichte 5 Tage nach Verabreichung der Injektion ihr Maximum. Die natürliche Aktivi-tat von Killer-Zellen und die Chemoluminizenz-Reaktion der Nieren-Leukozyten in den mit dem Extrakt behandelten Fischen waren gegenüber Tieren, denen Albumin injiziert wurde, signifikant erhoht. Regenbogenforellen, denen der Abalone-Extrakt intraperitoneal injiziert wurde, zeigten eine erhohte Resistenz gegen Vibrio anguillarum.〈section xml:id="abs1-3"〉〈title type="main"〉Résumé Effects immunomodulatoires chez la truite arc-en-ciel, Onchorhynchus mykiss, traitie par des injections d'extraits d'onneaux, Haliotis discus hannai La truite arc-en-ciel, Onchorhynchus mykiss, traitie par injection d'une fraction aqueuse extraite d'ormeaux, Haliotis discus hannai, a montré une augmentation du taux de phagocytose. Cette augmentation de I'activité a atteint son niveau maximal cinq jours aprés injection. Les activitts naturelles des cellules tueuses et les résonses chimioluminescentes des leucocytes du rein des poissons traitis par cette fraction ont aussi significativement augmentis, par rapport ä celle des poissons traitis par de l'albumine. Les truites arc-en-ciel uaities par des injections intrapiritoniales de cette fraction ont montré une résistance accrue äVibrio anguillarum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0426.1991.tb00594.x
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  • 10
    Electronic Resource
    Electronic Resource
    Influence of GaAs surface stoichiometry on the interface state density of as-grown epitaxial ZnSe/epitaxial GaAs heterostructures (1990)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 56 (1990), S. 1272-1274 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Epitaxial ZnSe/epitaxial GaAs interfaces have been formed by molecular beam expitaxy and evaluated by several techniques including capacitance-voltage measurements. In the study reported here, the GaAs surface stoichiometry was systematically varied prior to the nucleation of ZnSe. A dramatic reduction of interface state density occurred when the GaAs epilayer was made As deficient. The resulting interface state densities of as-grown structures are comparable to values obtained with (Al,Ga)As/GaAs interfaces.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.102534
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