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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 112 (1990), S. 4-7 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 94 (1990), S. 7656-7661 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous work has identified the intermediate and medial part of the hyperstriatum ventrale (IMHV) as a region of the chick brain storing information acquired through the learning process of imprinting. We have examined in this brain region changes in expression of candidate genes involved in memory. Chicks were exposed to a rotating red box and the strength of their preference for it, a measure of learning, determined. Brain samples were removed ≈24 h after training. Candidate genes whose expressions were different in IMHV samples derived from strongly imprinted chicks relative to those from chicks showing little or no learning were identified using subtractive hybridization. The translation products of two candidate genes were investigated further in samples from the left and right IMHV and from two other brain regions not previously implicated in imprinting, the left and right posterior neostriatum. One of the proteins was the amyloid precursor protein (APP), the other was myristoylated alanine rich C kinase substrate (MARCKS). In the left IMHV the levels of the two proteins increased with the strength of learning. The effects in the right IMHV were not significantly different from those in the left. There were no effects of learning in the posterior neostriatum. This is the first study to relate changes in the amounts of MARCKS and APP proteins to the strength of learning in a brain region known to be a memory store and demonstrates that the systematic identification of protein molecules involved in memory formation is possible.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 125 (1991), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary A case of relapsing polychondritis (RPC) with strongly positive antibodies to both native and denatured type II collagen is reported. This is only the second report of the use of cyclosporin A in the treatment of RPC.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    Engineering computations 18 (2001), S. 347-376 
    ISSN: 0264-4401
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Technology
    Notes: A general philosophy is presented in which all the modules within the computational cycle are parallelised and executed on parallel computer hardware, thereby avoiding the creation of computational bottlenecks. In particular, unstructured mesh generation with adaptation, computational fluid dynamics and computational electromagnetic solvers and the visualisation of grid and solution data are all performed in parallel. In addition, all these modules are embedded within a parallel problem solving environment. This paper will provide an overview of these developments. In particular, details of the parallel mesh generator, which has been used to generate meshes in excess of 100 million elements, will be given. A brief overview will be presented of the approach used to parallelise the solvers and how large data sets are interrogated and visualised on distributed computer platforms. Details of the parallel adaptation algorithm will be presented. These parallel component modules are linked using CORBA communication to provide an integrated parallel approach for large scale simulations. Several examples are given of the approach applied to the simulation of large aerospace calculations in the field of aerodynamics and electromagnetics.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  This paper presents a method for simulating, in the time domain, the scattering of electromagnetic waves in piecewise homogeneous media. The method employs an explicit Taylor–Galerkin approach, implemented on a general unstructured triangular grid, with the electric and magnetic fields approximated in a continuous piecewise linear fashion. All boundary and material interface conditions are weakly applied in an integral form, following a characteristic decomposition of the solution. A number of simple examples, for which exact scattering width distributions are available, are included to demonstrate the numerical performance of the proposed procedure.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Women who carry mutations in the BRCA1 gene on chromosome 17q have an 85% lifetime risk of breast cancer, and a 60% risk of ovarian cancer. We have identified BRCA1 mutations in 12 of 30 (40%) Canadian families with breast and/or ovarian cancer, including six of the eight families (75%) that ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Computational mechanics 11 (1993), S. 433-451 
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A finite element based procedure for the solution of the compressible Euler equations on unstructured tetrahedral grids is described. The spatial discretisation is accomplished by means of an approximate variational formulatin, with the explicit addition of a matrix form of artificial viscosity. The solution is advanced in time by means of an explicit multi-stage time stepping procedure. The method is implemented in terms of an edge based representation for the tetrahedral grid. The solution procedure is accelerated by use of a fully unstructured multigrid algorithm. The approach is applied to the simulation of the flow past an installed aero-engine nacelle, at three different free stream conditions. Comparison is made between the numerical predictions and experimental pressure observations.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1939
    Keywords: Adélie Penguin ; energetics ; Microclimate ; Reproduction ; Thermoregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We measured meteorological conditions and estimated the energy costs of thermoregulation for young and adult Adélie Penguins (Pygoscelis adeliae) at a breeding colony near the Antarctic Peninsula. Air temperatures averaged 〈 5°C and strong winds were frequent. Operative temperatures (Te) for adults ranged from −8 to 28°C, averaging 5–6°C, for the period from courtship to fledging of chicks. The average energy cost of thermoregulation (Cth) for adult penguins was equivalent to 10–16% of basal metabolism. Cth comprised about 15% of the estimated daily energy budget (DEB) of incubating adults, but only about 1% of the DEB of adults feeding chicks. The Te's for chicks older than 14 days ranged from 0 to 31°C, averaging 8.0 C. The Cth for downy chicks ranged from about 31% of minimal metabolic rate (MMR) in 1 kg chicks to about 10% of MMR in 3 kg chicks. Between initial thermal independence (age 12–14 days) and the cessation of parental feeding (age 35–40 days), chicks use about 10–11% of assimilated energy for thermoregulation. Cth is equivalent to about 17% of the MMR of fledglings during their 2–3 week fast. We observed no indication of thermal stress (i.e., conditions in which birds cannot maintain stable Tb) in adults and no indication of cold stress in any age class. However, on clear, calm days when air temperature exceeds 7–10°C for several hours, downy chicks are vulnerable to lethal hyperthermia.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 19 (1994), S. 827-847 
    ISSN: 0271-2091
    Keywords: TVD ; Unstructured mesh algorithms ; Euler equations ; Hypersonic flows ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The Galerkin finite element method is used as the basis for the construction of schemes for the solution of the two-dimensional compressible Euler equations on unstructured triangular grids. The use of a side-based data structure readily allows for the construction of a local (structured) stencil and the incorporation of a high-resolution shock-capturing method formulated within the TVD concept. The essential features of the finite element side-based scheme and the ID TVD approach are described and their numerical implementation is discussed. The choice of limiters and the support for their computation are analysed and the solutions of some inviscid flows, obtained by advancing explicitly in time, are presented.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
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