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  • 1
    Electronic Resource
    Electronic Resource
    Brain-associated cell surface antigens on neuroepithelial cells in a transplantable mouse teratoma (1977)
    Springer
    Acta neuropathologica 39 (1977), S. 281-287 
    Details
    ISSN: 1432-0533
    Keywords: Neuroepithelial differentiation ; Microcomplement fixation ; Indirect immunofluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mouse neonatal brain cell fractions enriched for surface membranes were used as immunogens to produce a heterologous immune serum. Following absorption to remove non-neural anti-mouse activity, this serum demonstrated by microcomplement fixation an anti-brain activity that was completely removed by absorption with neonatal mouse brain or with solid tumors of the mouse transplantable teratoma OTT-6050. Indirect immunofluorescence applied to living monolayer cultures of differentiating teratoma embryoid bodies showed the absorbed serum's reaction with neural cell surfaces only. In material studied with frozen sections, the absorbed serum recognized antigenic sites in all examined areas of both neonatal and adult mouse brain, and only within neuroepithelial cell populations of solid transplants of the teratoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691708
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  • 2
    Electronic Resource
    Electronic Resource
    Spectroscopic and ab initio investigation of the νOH overtone excitation in trans-formic acid (2000)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 113 (2000), S. 1535-1545 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Fourier transform spectroscopy and intracavity laser absorption spectroscopy are used to record the absorption spectrum of formic acid at high spectral resolution, in the ranges of the 2νOH (6968.258 cm−1) and 4νOH (13 284.075 cm−1) vibrational bands of the trans-rotamer, respectively. Numerous perturbations combined with a large line density limit the extent to which the vibration–rotation analysis is performed. Some 689 lines are assigned in the first overtone band and related vibration–rotation constants are determined. Only the band origin and upper state principal A-rotational constant are determined for the n=4 overtone band, because of much higher spectral density. Interpolation, helped by literature data, provides all missing principal rotational constants in the nOH series, for n=1 to 4. All major vibration–rotation parameters appear to evolve very smoothly along the series. This trend is fully supported by ab initio calculations performed at the MP2/cc-pVTZ level of theory and based on an effective one-dimensional model describing the OH local mode stretching vibration. Results of these calculations are detailed in terms of the mean nuclear structure in the excitation series, up to n=4. The related calculated dipole moment surface allows the experimental a:b subband intensity ratio in the series to be interpreted in terms of a decrease in the HOC angle, from Θ(approximate)90° (n=1) to 44°(n=4). The potential occurrence of a proton exchange mechanism between the two oxygen nuclei, close to a tautomerism mechanism, is discussed. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.481939
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  • 3
    Electronic Resource
    Electronic Resource
    Counseling and Student Development (1975)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Psychology 26 (1975), S. 337-366 
    Details
    ISSN: 0066-4308
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ps.26.020175.002005
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  • 4
    Electronic Resource
    Electronic Resource
    EFFECTS OF OSMOLAR CHANGES ON ISOLATED MITOCHONDRIA OF BRAIN AND LIVER (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The effects of altered osmolarity on respiration and fine structure were compared in isolated rat cerebral versus liver mitochondria.Polarographic study of cerebral mitochondria in hypo-osmolar media showed inhibition of State 3 (ADP-dependent) respiration which was not reversed by dinitrophenol. In hyperosmolar media, State 3 respiration was transiently inhibited and State 4 (ADP-independent) respiration increased with the NAD-linked substrate pair, glutamate and malate. With succinate as substrate, respiration was not affected by moderate hyperosmolarity. In the most hyperosmolar medium, State 3 respiration was inhibited with both substrates.In contrast to the results with cerebral mitochondria, State 4 respiration was increased in hypo-osmolar media and State 3 respiration was persistently inhibited in hyperosmolar media in liver mitochondria with both substrates.In both cerebral and liver mitochondria, cytochrome c oxidase (EC 1.9.3.1.) activity was mildly inhibited in hypo-osmolar media and increased in hyperosmolar media.Electron microscopy showed that liver mitochondria were swollen in hypo-osmolar media and condensed in hyperosmolar media. Cerebral mitochondria showed mild rarefaction in hypo-osmolar media and, in hyperosmolar media, more than half the mitochondria showed either no or minimal changes in fine structure.Our results suggest that there are differences in metabolic control and structure between mitochondria from different cell types, which may be important in the cellular metabolic response to pathologic changes in water or osmolarity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb10473.x
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  • 5
    Electronic Resource
    Electronic Resource
    Glial fibrillary acidic protein-solubility characteristics, relation to cell growth phases and cellular localization in rat C-6 glioma cells: an immunoradiometric and immunohistologic study (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb12415.x
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  • 6
    Electronic Resource
    Electronic Resource
    NON-HISTONE CHROMOSOMAL PROTEINS IN MOUSE BRAIN AT DIFFERENT STAGES OF DEVELOPMENT AND IN A TRANSPLANTABLE MOUSE TERATOMA (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 29 (1977), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Non-histone chromosomal proteins (NHCP) from mouse brain at different stages of development and from adult liver and kidney of strain related mice were analyzed by SDS-polyacrylamide gel electrophoresis and were compared with the mouse teratoma, OTT-6050. The fetal, neonatal and adult brains were qualitatively similar in their NHCP profiles but had quantitative differences. The NHCP composition of the adult brain was clearly distinct from that of the liver and kidney and was dissimilar from that of the teratoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1977.tb10723.x
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  • 7
    Electronic Resource
    Electronic Resource
    Alterations in trkB mRNA in the human prefrontal cortex throughout the lifespan (2002)
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 15 (2002), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Signalling through tyrosine kinase receptor B (trkB) influences neuronal survival, differentiation and synaptogenesis. trkB exists in a full-length form (trkBTK+), which contains a catalytic tyrosine kinase (TK) domain, and a truncated form (trkBTK–), which lacks this domain. In the rodent brain, expression of trkBTK+ decreases and trkBTK– increases during postnatal life. We hypothesized that both forms of trkB receptor mRNA would be present in the human neocortex and that the developmental profile of trkB gene expression in human may be distinct from that in rodent. We detected both trkBTK+ and trkBTK– mRNA in RNA extracted from multiple human brain regions by Northern blot. Using in situ hybridization, we found trkBTK+ mRNA in all cortical layers, with highest expression in layer IV and intermediate-to-high expression in layers III and V of the human dorsolateral prefrontal cortex. trkBTK+ mRNA was present in neurons with both pyramidal and nonpyramidal shapes in the dorsolateral prefrontal cortex. trkBTK+ mRNA levels were significantly increased in layer III in young adults as compared with infants and the elderly. In the elderly, trkBTK+ mRNA levels were reduced markedly in all cortical layers. Unlike the mRNA encoding the full-length form of trkB, trkBTK– mRNA was distributed homogeneously across the grey matter, and trkBTK– mRNA levels increased only slightly during postnatal life. The results suggest that neurons in the human dorsolateral prefrontal cortex are responsive to neurotrophins throughout postnatal life and that this responsiveness may be modulated during the human lifespan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0953-816x.2001.01858.x
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  • 8
    Electronic Resource
    Electronic Resource
    Quantitative increase of neuroglia-specific GFA protein in rat C-6 glioma cells in vitro (1975)
    [s.l.] : Nature Publishing Group
    Nature 255 (1975), S. 633-634 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] C-6 cells and mouse strain L-929 fibroblasts, both obtained from the American Type Culture Collection, were maintained at 36-37 C in several systems. Monolayer cultures were grown in Roux bottles in a medium consisting of minimal essential medium?Spinner solution (Grand Island Biological Co., Grand ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/255633a0
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  • 9
    Electronic Resource
    Electronic Resource
    Nuclear Data for Applications (2000)
    Springer
    Journal of radioanalytical and nuclear chemistry 243 (2000), S. 227-233 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Nuclear data are numerical quantities that describe nuclear properties and nuclear interactions. Arranged into data libraries, they ultimately constitute the very basis of all nuclear applications. Nuclear data have to be measured, compiled, evaluated and validated so that users get the best and up-to-date information in an unrestricted manner. The paper provides an insight into this activity, describes the process from measurements to nuclear data services, illustrates key applications, and discusses future trends and developments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006712607567
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  • 10
    Electronic Resource
    Electronic Resource
    Comparative studies of glucose-fed and glucose-starved hamster cell cultures: Responses in galactose metabolismThis work was supported by grants from the American Cancer Society BC-120 and the National Institutes of Health AM-05507 and the National Science Foundation BMS71-01291 A03. This is publication No. 1517 of the Cancer Commission of Harvard University. (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 90 (1977), S. 387-405 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The metabolic flow of trace amounts of D-[14C]-galactose was followed in cultures of transformed and untransformed hamster cells over a period ranging from five minutes to two hours. The results of chromatographic and enzymatic analyses of the soluble pools are described. Non-glycolytic cells (previously deprived of sugar for periods of up to 24 hours) convert D-galactose to galactose-1-phosphate and uridine diphosphoglucuronic acid in 10 to 20 minutes. In the same short assay time, glycolytic cells which have been maintained for 24 hours in media containing glucose or galactose convert D-galactose to uridine diphosphogalactose and uridine diphosphoglucose (ratio 1.4:1). Longterm deprivation of sugar also results in 3- to 4-fold increases in the uptake of galactose. In addition, the incorporation of galactose label into chloroform-methanol soluble material appears to be influenced by the culture conditions of the untransformed cells while incorporation in the transformed cells appears unaffected. When cycloheximide is included in the maintenance medium for extended periods, the non-glycolytic cells also show increases in galactose uptake rates but the glucose-fed, glycolytic cells lose uptake ability. UDPhexose is the main galactose metabolic peak in the soluble pools of the cycloheximide-treated, glycolytic and the cycloheximide-treated, non-glycolytic cells. The results of these experiments suggest that uptake of galactose and its subsequent metabolism are under separate control.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040900303
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