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  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 112 (2000), S. 5488-5498 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Beginning with the molecular-based Fokker–Planck equation obtained previously [M. H. Peters, J. Chem. Phys. 110, 528 (1999); J. Stat. Phys. 94, 557 (1999)], the Smoluchowski diffusion equation is derived here to describe the spatial and orientational dynamics of molecularly structured macromolecules near molecularly structured surfaces. The formal scaling and perturbation methods employed allow the establishment of definite limits on the use of the Smoluchowski equation when surfaces are present. It is shown that the Smoluchowski equation reduces to that given previously [D. W. Condiff and J. S. Dahler, J. Chem. Phys. 44, 3988 (1966)] in the absence of external surfaces. A specific example application is given involving a spherical macromolecule with electrostatic charge segments near a planar surface with an arbitrary charge distribution. Finally, we show that the short-time solution to the Smoluchowski equation obtained here yields a Brownian dynamics method consistent with that given previously [E. Dickinson, S. A. Allison, and J. A. McCammon, J. Chem. Soc. Faraday Trans. 2 81, 591 (1985)] for orientable, interacting Brownian particles. This study has applications to problems involving site-specific adsorption of orientable, structured Brownian particles, such as association or adsorption of biological macromolecules to cellular surfaces and enzyme–substrate docking kinetics, to name a few. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 6719-6721 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A new series of Sm(CowFevCuxZry)z alloys has been developed to produce magnets with high intrinsic coercivity iHc at high temperatures for use up to 550 °C. The maximum use temperature is defined as TM, which is the maximum temperature at which the extrinsic demagnetization curve is a straight line. An important feature of the alloys with high TM is a lower temperature coefficient of iHc, β. These magnets have a higher resistance to demagnetization from increasing thermal agitation which occurs with increasing temperature. A study on magnetic pinning field Hp, which will be explained in the text, vs TM was conducted by measuring the initial magnetization curves of the magnets at 25 and 300 °C. The study shows that as TM increases, Hp increase at high temperatures. At 25 °C, all magnets with TM from 250 to 550 °C have Hp higher than 24 kOe, which is too high to be determined using a hysteresigraph. At 300 °C, the magnet with TM=250 °C has Hp=7.0 kOe, and the magnet with TM=550 °C has Hp=15.1 kOe. Higher pinning field at high temperatures (≥300 °C) provides a greater resistance to thermal demagnetization, which leads to better performance at high temperatures. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 8 (2001), S. 4202-4210 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The current carried by a steady-state, finite-width beam produced by space-charge-limited emission in two-dimensional parallel plate geometry is known to diverge strongly from estimates based on the classic one-dimensional Child–Langmuir problem. The two-dimensional problem presents formidable analytic difficulties, but a numerical approach to this problem has been developed. The approach simultaneously determines the electrostatic potential and the unknown current density profile. Calculations show that the total current is a function of the dimensionless ratio of beam width (w) to anode–cathode gap (d), but that the current density profile varies with both w and d separately. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In recent Petawatt laser experiments at Lawrence Livermore National Laboratory, several hundred joules of 1 μm laser light in 0.5–5.0-ps pulses with intensities up to 3×1020 W cm−2 were incident on solid targets and produced a strongly relativistic interaction. The energy content, spectra, and angular patterns of the photon, electron, and ion radiations have all been diagnosed in a number of ways, including several novel (to laser physics) nuclear activation techniques. About 40%–50% of the laser energy is converted to broadly beamed hot electrons. Their beam centroid direction varies from shot to shot, but the resulting bremsstrahlung beam has a consistent width. Extraordinarily luminous ion beams (primarily protons) almost precisely normal to the rear of various targets are seen—up to 3×1013 protons with kTion∼several MeV representing ∼6% of the laser energy. Ion energies up to at least 55 MeV are observed. The ions appear to originate from the rear target surfaces. The edge of the ion beam is very sharp, and collimation increases with ion energy. At the highest energies, a narrow feature appears in the ion spectra, and the apparent size of the emitting spot is smaller than the full back surface area. Any ion emission from the front of the targets is much less than from the rear and is not sharply beamed. The hot electrons generate a Debye sheath with electrostatic fields of order MV per micron, which apparently accelerate the ions. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Boston, USA and Oxford, UK : Blackwell Publishers Inc
    Psychology of women quarterly 25 (2001), S. 0 
    ISSN: 1471-6402
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Notes: A convenience sample of 57 lesbian women who had been recruited for a study of adjustment to breast cancer completed measures of internalized homophobia, degree of disclosure of sexual orientation, social support, self-esteem, and distress. Consistent with our prediction, internalized homophobia related to greater distress. Contrary to our prediction, disclosure did not relate to lower distress. Path models were consistent with the position that internalized homophobia promotes distress through lower self-esteem and perceived unavailability of social support. However, the data were also consistent with a model in which low self-esteem leads to internalized homophobia by way of elevated distress. Internalized homophobia also related inversely to utilization of health care resources. Our discussion centers on the need for more information regarding this understudied population.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    350 Main Street , Malden , MA 02148-5018 , USA and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 27 (2004), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An implantable cardioverter defibrillator with atrial therapies (ICD-ATs) is an effective therapy to manage atrial tacharrhythmias. Acceptance of this therapy is limited by atrial shock related anxiety and discomfort. Inhaled nitrous oxide (N2O) is a potent sedative-analgesic-anxiolytic agent that may mitigate shock discomfort and anxiety and improve patient ICD-AT acceptance. ICD-AT patients with more than one ambulatory atrial shock within 12 months were enrolled and grouped by ICD-AT shock method; awake (n = 9) or asleep (n = 4) when ambulatory ICD-AT shock is delivered. A baseline questionnaire assessed the most recent ambulatory ICD-AT shock (3 ± 3 months). A 65% N2O/35% O2 mixture was inhaled for 4 minutes followed by an ICD-AT test shock (18 ± 8 J). The test shock mimicked the awake shock method. The test shock experience during N2O was evaluated via questionnaire immediately following and 24 hours after the shock. Shock related anxiety, intensity, pain, and discomfort were assessed using a ten-point rank scale. Baseline test shock scores were similar between the shock method groups. In the awake shock method group, N2O greatly reduced preshock anxiety by 48% (6.4 ± 2.4 to 3.3 ± 2.0, or), and shock related intensity (5.9 ± 3.1 to 3.3 ± 2.5), pain (5.0 ± 2.6 to 2.0 ± 2.1), and discomfort (5.6 ± 2.4 to 1.3 ± 1.4) from baseline values by 45%, 60%, and 78% (P 〈 0.05), respectively. The asleep shock method group reported no changes in shock related anxiety, intensity, pain, or discomfort. Atrial shock concern, assessed via a five-point rank scale (5 = extreme concern) was improved by N2O but only in the awake group (3.1 ± 1.0 baseline to 1.6 ± 0.5 N2O, P = 0.008). There were no adverse events with N2O and patients fully recovered within 5 minutes after N2O. In conclusion, 65% N2O greatly reduced shock related pain and discomfort, and significantly reduced atrial shock concern but only in the awake shock method group. The benefits of N2O therapy may expand the use and acceptability of ICD-AT therapy into a larger atrial fibrillation cohort. (PACE 2004; 27:485–491)
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Futura Publishing, Inc.
    Pacing and clinical electrophysiology 25 (2002), S. 0 
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: BLOOMFIELD, D.M., et al.: The Immediate Reproducibility of T Wave Alternans During Bicycle Exercise. A number of recent studies have demonstrated that the microvolt level T wave alternans measured during bicycle exercise can identify patients at high risk for developing malignant ventricular arrhythmias. However, little is known about the reproducibility of T wave alternans measured during bicycle exercise. The purpose of this study was to prospectively evaluate the immediate reproducibility of T wave alternans measured during bicycle exercise testing. Thirty-five patients with congestive heart failure underwent two sequential bicycle exercise tests with the measurement of T wave alternans. The T wave alternans tests were randomly sorted and then classified by two readers who were blinded to the patient and the sequence of the two tests. Tests were classified as determinate (positive or negative) or indeterminate according to previously published criteria. Of the 22 patients that had two determinate T wave alternans tests, 18 (82%) of 22 patients had concordant test results (kappa 0.58). Of the four patients who had discordant test results on the two tests, three patients had one test that was borderline and difficult to interpret. One patient had two sequential tests that were clearly different. Of the ten patients whose initial test was indeterminate, five became determinate on the second test. T wave alternans measured during bicycle exercise has an acceptable reproducibility when measurements are made from two sequential exercise tests performed within a short period. This data suggests that the measurement of T wave alternans during exercise is reliable. Repeating the exercise test with a second measure of T wave alternans during the same session can significantly reduce the proportion of patients with indeterminate test results.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We examined sleeping problems in women with metastatic breast cancer in relation to depression, social support, and salivary cortisol. Ninety-seven women with metastatic breast cancer were drawn from a larger study on the effects of group therapy on quality of life and survival. This study is based on the baseline assessments conducted prior to randomization into treatment conditions. Sleep, depression symptoms, and social support were assessed by self-reporting. Cortisol was assessed from saliva samples taken over a 3-day period. Medical status and demographic characteristics were also examined in relation to each sleep variable in multiple regression analysis. Most women (63%) reported one or more types of sleep disturbance and 37% reported using sleeping pills in the previous 30 days. Problems with falling to sleep were significantly related to greater pain and depressive symptoms. Problems of waking during the night were significantly associated with greater depression and less education. Problems in waking/getting up were significantly associated with greater depressive symptoms and less social support. Sleepiness during the day was not significantly related to the variables in the regression model. Fewer hours of sleep were significantly associated with metastases to the bone, higher depressive symptoms, and more social support. Women who reported sleeping 9 or more hours per night, compared to those who reported a moderate amount of sleep (6.5–8.5 hours), had significantly lower 9 p.m. cortisol levels. Use of sleeping pills was more frequent among women reporting greater pain and depressive symptoms. These results suggest that women with metastatic breast cancer who are at higher risk for having sleeping problems are those who are less educated, in pain, depressed, have bony metastases, or lack social support.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd.
    Journal of management studies 41 (2004), S. 0 
    ISSN: 1467-6486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: We argue that the challenges faced by threshold firms are deeply rooted in governance characteristics (i.e. the incentives, authority and legitimacy) which imbue them with characteristic capabilities, disabilities and path dependencies. Whereas Zahra and Filatotchev (2004) reason the principal problem facing threshold firms relates to organizational learning and knowledge management, we posit resource acquisition and utilization to be equally important. Moreover, we argue governance theory is more able than a knowledge-based perspective to explain the root causes of the learning and resource issues faced by threshold firms as well as the complex set of processes involved in their effective management.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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