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  • 1
    Electronic Resource
    Electronic Resource
    Cyclooxygenase 2 (COX2) expression is associated with poor outcome in ER-negative, but not ER-positive, breast cancer (2004)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 45 (2004), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims:  Inflammation and hormonal signalling induce cyclooxygenase 2 (COX2) expression in solid tumours. COX2 expression is linked to neovascularization and tumour growth. HER2 modulates colorectal cancer COX2 expression. We investigated interactions between COX2 and HER1–4 in breast cancer.Methods and results:  COX2 expression was localized to epithelial cells with 21.2% of cases expressing higher levels than normal epithelium. Elevated COX2 expression was not associated with size, grade, high Nottingham prognostic index (NPI) or oestrogen receptor (ER) negativity. No association was observed between COX2 and HER1–4 expression. High COX2 expression was associated with reduced disease-free survival (P = 0.03) and disease-related survival in ER-negative (P = 0.046) but not ER-positive disease (P = 0.835).Conclusion:  HER1, 2, 3 and 4 are not associated with high breast tumour COX2 expression. COX2 is frequently expressed in breast carcinoma cells and adjacent epithelium. COX2 may be an important factor in promoting tumour progression in ER-negative tumours and a potential drug target in breast tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2004.01898.x
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  • 2
    Electronic Resource
    Electronic Resource
    Residential expansion as a continental threat to U.S. coastal ecosystems (2000)
    Springer
    Population and environment 21 (2000), S. 429-468 
    Details
    ISSN: 1573-7810
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Sociology
    Notes: Abstract Spatially extensive analysis of satellite, climate, and census data reveals human-environment interactions of regional or continental concern in the United States. A grid-based principal components analysis of Bureau of Census variables revealed two independent demographic phenomena, α-settlement reflecting traditional human settlement patterns and β-settlement describing relative population growth correlated with recent construction in non-agricultural areas, notably in coastal, desert, and “recreational” counties and around expanding metropolitan areas. Regression tree analysis showed that β-settlement was differentially associated with five distinct combinations of seasonality, summer heat or cool, intensity of agriculture, and extent of “barren” land. Beta-settlement was greatest in coastal and desert areas, and coincided with national concentrations of threatened and endangered species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02436749
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Driving reaction time after right knee arthroscopy (2000)
    Springer
    Knee surgery, sports traumatology, arthroscopy 8 (2000), S. 89-92 
    Details
    ISSN: 1433-7347
    Keywords: Key words Driving reaction time ; Knee arthroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Sports Science
    Notes: Abstract Driving reaction times of 30 right knee arthroscopy patients were measured using a computer-linked car simulator. Each patient was tested pre-operatively and ¶1 week after and 4 weeks after arthroscopy. As controls, 25 normal subjects were also tested. In the control group the average reaction time was 634 ms; the measurements at ¶1 week and at 4 weeks were 550 ms and 582 ms, respectively. In the arthroscopy group the average reaction time pre-operatively was 736 ms; the measurements 1 week and ¶4 weeks post-operatively were 920 ms and 685 ms, respectively. Two clinical tests (the stepping and standing tests) were also performed at each assessment. Statistical analysis showed a good correlation between these and reaction time. We conclude that it is appropriate for patients to delay their return to driving for at least 1 week, and that the actual timing of return to driving may be determined by performance on these two clinical tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001670050192
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    Paper (German National Licenses)
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