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  • 1
    ISSN: 1432-0428
    Keywords: Keywords MODY, HNF-4α, HNF-1α, L-type pyruvate kinase, insulin.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Mutations in the hepatocyte nuclear factor (HNF)-4 α gene cause the type 1 form of maturity-onset diabetes of the young (MODY1). The R127W mutation is a missense mutation located in the T-box region of HNF-4α that was first identified in a Japanese family with MODY. We have examined the functional properties of this mutation in order to clarify the molecular basis of MODY1.¶Methods. The intracellular localisation, DNA binding ability, transactivation activity and functional synergism with the coactivator CREB-binding protein (CBP) of R127W-HNF-4α were investigated.¶Results. The nuclear import and functional synergy with CBP of R127W-HNF-4α were normal. The DNA binding ability of the mutant was decreased as was its transcriptional activation of the HNF-1 α and L-type pyruvate kinase (PKL) genes.¶Conclusion/interpretation. The R127W mutation seems to be a loss-of-function mutation. [Diabetologia (2000) 43: 520–524]
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 115 (2001), S. 3287-3296 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The mechanism of the cycloaddition reaction between thiophene and Si(111)-7×7 has been investigated using thermal desorption spectroscopy (TDS), high resolution electron energy loss spectroscopy (HREELS), electronic electron energy loss spectroscopy (EELS), scanning tunneling microscopy (STM), and PM3 semiempirical calculations. The results show that thiophene binds on Si(111)-7×7 through a [4+2] cycloaddition reaction between the 2, 5 C-atoms of thiophene and the adjacent adatom-rest atom pairs on Si(111)-7×7. Semiempirical PM3 calculations based on the cluster model further confirm this di-σ bonding configuration. A stepwise surface diradical mechanism has been proposed to account for the regioselective [4+2] cycloaddition reaction. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 112 (2000), S. 10131-10141 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Novel improvements of the pseudospectral method for assembling the Coulomb operator are discussed. These improvements consist of a fast atom centered multipole method and a variation of the Head–Gordan J-engine analytic integral evaluation. The details of the methodology are discussed and performance evaluations presented for larger molecules within the context of DFT energy and gradient calculations. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Inorganic nanoparticles exhibit size-dependent properties that are of interest for applications ranging from biosensing and catalysis to optics and data storage. They are readily available in a wide variety of discrete compositions and sizes. Shape-selective synthesis strategies now also yield ...
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Electron cyclotron resonance (ECR) ion sources are used for cyclotron complex and atomic physics research at the Institute of Modern Physics (IMP). Intense beams of highly charged gaseous and metallic ions could be produced by the IMP 14.5 GHz ECR ion source (LECR2-Lanzhou Electron Cyclotron Resonance Ion Source No. 2). A particular emphasis has been put on the production of metallic ion beams recently. Metallic ion beams of Mg, Ca, Fe, Ni, Cu, Zn, and Pb were tested at the IMP 14.5 GHz ECR ion source (LECR2) to improve beam intensities and long-term stability. A new ECR ion source (Lanzhou Electron Cyclotron Resonance Ion Source No. 3), an upgraded version of the IMP 14.5 GHz ECR (LECR2) but with double-frequency wave heating (10 GHz+14.5 GHz), is under commissioning. The preliminary results of this new source will be presented. To satisfy the requirements of the heavy ion cooling storage ring that is under construction at IMP, a fully superconducting ECR ion source (Lanzhou Electron Cyclotron Resonance Ion Source with Superconducting Coils) with a completely new structure is being developed for the production of intense heavy ion beams of very high charge states, such as Xe30+ and U40+. The superconducting magnet consists of three axial solenoid coils and six saddle-curved sextupole coils with a cold iron structure as field booster and clamp. At full excitation, this magnet assembly will produce maximum peak fields on axis of 4.0 T at the injection, 2.2 T at the extraction region, and a radial sextupole field of 2.0 T at plasma chamber wall. The design features and status of this new superconducting ECR ion source will be presented. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A new electron cyclotron resonance (ECR) ion source (LECR3—Lanzhou Electron Cyclotron Resonance Ion Source No. 3) has been constructed this year. The main purpose of this source is to provide highly charged ion beams for atomic physics and surface physics research. The design of this ion source is based on the IMP 14.5 GHz ECR ion source (LECR2—Lanzhou Electron Cyclotron Resonance Ion Source No. 2) with double rf heating by inserting waveguide directly and aluminum chamber. Furthermore, the volume of the plasma chamber is larger than that of LECR2 so as to increase the rf power and improve beam intensity for highly charged ions. But the hexapole field on the chamber wall is kept the same value in order to compare with the performance of LECR2. After only four days conditioning the first test results were obtained. The final result of this ion source is expected to be better than LECR2's. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 112 (2000), S. 4759-4767 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The adsorption and binding of chlorobenzene (C6H5Cl) on clean and D-modified Si(111)-7×7 surfaces have been investigated using high resolution electron energy loss spectroscopy (HREELS) and thermal desorption spectroscopy (TDS). On a clean surface, both chemisorbed and physisorbed C6H5Cl are observed at an adsorption temperature of 110 K. The HREEL spectra show direct evidence for the presence of both sp2 and sp3 carbon atoms in chemisorbed C6H5Cl molecules on Si(111)-7×7. Upon D-modification, the chemisorption of C6H5Cl decreases rapidly with increasing D-coverage (θD). At θD=1/3 ML, only physisorbed chlorobenzene is detected, which strongly suggests the involvement of rest-atoms in the chemisorption of C6H5Cl. Combined with the scanning tunneling microscopy (STM) results by Chen et al. [Surf. Sci. 340, 224 (1995)] showing the participation of adatoms in the binding, we propose that the 2,5-carbon atoms in C6H5Cl are stereo-selectively di-σ bonded to a pair of adjacent adatom and rest-atom on the Si(111)-7×7 surface, yielding a 2,5-chlorocyclohexadienelike surface adduct. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Plant, cell & environment 27 (2004), S. 0 
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The stripe rust (or yellow rust) disease caused by Puccinia striiformis Westend is a serious disease of wheat in many areas of the world. The role of NO, which is an important redox-active signalling molecule in plants, was investigated in the wheat-stripe rust system. The phenotypes from interactions of the same wheat variety, Lovrin10, with two different clones of stripe rust strains (P. striiformis Westend), namely China yellow rust (CY)22-2 and CY29-1, which are immune and susceptible reaction types, respectively. The time course of host endogenous NO detected by electron spin resonance indicated that recognition of an avirulent strain was associated with two peaks of NO production. The first peak of NO accumulated in the early infection stage whereas the second peak accumulated in the latent period; however, only a single peak of NO was observed in the latent period for the virulent strain. Furthermore, the activity of pathogen-related protein-phenylalanine ammonia-lyase was higher in the resistant system than in the susceptible system, which suggested that the first NO production was associated with resistance. Exogenous NO improved the activity of phenylalanine ammonia-lyase and induced a resistant response of Lovrin10 to the virulent strain CY29-1, thereby providing further evidence that the first peak of NO production was associated with resistance. These results indicate that the first NO burst in the immune system plays an important role in the resistant reaction of wheat to strip rust.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 254-256 (Dec. 2003), p. 801-804 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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