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  • 1
    Electronic Resource
    Electronic Resource
    Influence of trocar placement and CO2 pneumoperitoneum on port site metastasis following laparoscopic tumor surgery (2000)
    Springer
    Surgical endoscopy and other interventional techniques 14 (2000), S. 193-197 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Port site metastasis — Abdominal wound metastasis — Laparoscopic surgery — Pneumoperitoneum — VX2 cancer — Tumor surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The mechanisms involved in the development of port site metastasis following laparoscopic tumor surgery remain controversial. Therefore, we decided to investigate the influence of trocar placement and CO2 pneumoperitoneum on abdominal wound implantation in relation to intraperitoneal tumor growth in a rabbit model. Methods: Rabbits received either CO2 pneumoperitoneum with insertion of nine trocars (pneumoperitoneum group, n= 15), insertion of nine trocars alone (nonpneumoperitoneum group, n= 15), or nine abdominal incisions (control group, n= 13) 3 days after intraperitoneal inoculation of VX2 cancer cells. Results: The frequency of overall wound implantation on day 17 in the pneumoperitoneum group (24.4%) and nonpneumoperitoneum group (27.4%) tended to be higher than that in the control group (15.3%) (p= 0.06). There was no significant difference among the three groups in the growth of cancer nodules on the omentum. Conclusions: The presence of a trocar may be a factor contributing to port site metastasis but CO2 pneumoperitoneum appears not to be a factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004649900099
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of different insufflation pressures during carbon dioxide pneumoperitoneum on the development of pulmonary metastasis in a mouse model (2000)
    Springer
    Surgical endoscopy and other interventional techniques 14 (2000), S. 578 -581 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Colon 26 — Colorectal cancer — Laparoscopic surgery — Pneumoperitoneum — Pulmonary metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The effects of different insufflation pressures on the development of pulmonary metastasis was investigated in a mouse laparoscopy model. Methods: BALB/C mice intravenously inoculated with colon 26 cells were randomized to one of five treatment groups (10 mice per group): pneumoperitoneum at different pressures of 5, 10 or 15 mmHg; full laparotomy for 60 min; or anesthesia control. Cancer nodules on the lung surface 19 days postoperatively were compared between groups. Results: (a) As compared with the control group, pneumoperitoneum at 10 and 15 mmHg and laparotomy enhanced the growth of pulmonary metastases (p 〈 0.01). (b) The growth of metastases also was greater in laparotomy group mice than in mice undergoing pneumoperitoneum at 5 and 10 mmHg (p 〈 0.05). Conclusions: These results suggest that the effects of different insufflation pressures on the growth of pulmonary metastases are not identical, and that pneumoperitoneum with high pressure may promote pulmonary metastases similar to those with laparotomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004640000098
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Pneumoperitoneum with carbon dioxide enhances liver metastases of cancer cells implanted into the portal vein in rabbits (2000)
    Springer
    Surgical endoscopy and other interventional techniques 14 (2000), S. 239-242 
    Details
    ISSN: 1432-2218
    Keywords: Key words: Laparoscopic surgery — CO2 pneumoperitoneum — Liver metastasis — Gastrointestinal cancer — VX2 cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Little is known about the role of the CO2 pneumoperitoneum on tumor cells that spread from the portal system into the liver during laparoscopic surgery for gastrointestinal malignancies. Therefore, we designed a study to investigate the effect of CO2 pneumoperitoneum on cancer cells implanted in the portal vein in a rabbit model. Methods: Immediately after intraportal inoculation of 2.5 × 105 cells of VX2 cancer, the rabbits received either CO2 pneumoperitoneum at a pressure of 10 mmHg for 30 min (pneumoperitoneum group, n= 14) or laparotomy alone for 30 min (laparotomy group, n= 14). Results: The number (p 〈 0.01) and area of cancer nodules (p= 0.045) on the liver surface on day 17 were greater in the pneumoperitoneum group than in the laparotomy group. The frequency of cancer nodules 〉3.0 mm in diameter was higher in the pneumoperitoneum group than in the laparotomy group (p 〈 0.001). Conclusions: Compared with laparotomy, CO2 pneumoperitoneum enhanced the development of liver metastases in this experimental model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004640000047
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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