Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Transgenic mice overexpressing α2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis (2000)
    Springer
    Diabetologia 43 (2000), S. 899-906 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetes, insulin, catecholamines, α2-agonist, adrenoceptor, islets, transgenic mice.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. To study the role of the human α2A-adrenoceptor in the regulation of insulin secretion and the maintenance of glucose homeostasis in transgenic mice overexpressing this receptor in pancreatic beta cells.¶Methods. A human insulin promoter/human α2C10-adrenoceptor chimeric gene was microinjected into mouse embryos and transgenic mice were obtained.¶Results. Analysis by RT-PCR showed that the expression of the transgene was restricted to pancreatic islets. Study of the binding of the α2-antagonist [3H]RX821 002 to membrane preparations showed that islets from transgenic mice had ninefold higher α2-adrenoceptor density than those from controls. Immunohistological analysis showed, however, no change in the number or size of islets between control and transgenic mice. Transgenic animals had normal glycaemia and insulinaemia in basal conditions but greater hyperglycaemic and hypoinsulinaemic responses after injection of the α2-agonist, UK14 304. The lower blood insulin concentration detected in transgenic mice was a reflection of a stronger inhibitory effect of the α2-agonist on glucose-stimulated insulin secretion in transgenic islets than in controls. Furthermore, transgenic mice did not have lower glycaemia to basal values after an intraperitoneal glucose tolerance test. This defect was abolished by treatment with the α2-adrenoceptor antagonist, RX821 002.¶Conclusion/interpretation. These results provide evidence in vivo that overexpression of α2-adrenoceptors in beta cells can lead to impaired insulin secretion and glucose intolerance. [Diabetologia (2000) 43: 899–906]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051467
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Book review (2000)
    Springer
    Abdominal imaging 25 (2000), S. 216-216 
    Details
    ISSN: 1432-0509
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619910050
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Directed dynamic self-assembly of objects rotating on two parallel fluid interfaces (2002)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 116 (2002), S. 8571-8577 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: This paper describes dynamic self-assembly of millimeter-sized objects rotating at two parallel fluid interfaces and interacting with one another hydrodynamically, both in the plane of the interface and between the interfaces. The nature of hydrodynamic interactions between the objects rotating on different interfaces and, consequently, the morphologies of the ordered structures that self-assemble, depend on the sizes and the three-dimensional shapes of the rotating particles. Large particles rotating on one interface ("templates") can direct the self-assembly of smaller particles ("substrates") on the other interface. Two examples of directed self-assembly are discussed: (i) selective dimerization of disk spinning on the lower interface under the influence of cylinders rotating on the upper interface, and (ii) assembly of "substrate" rectangles into a pattern of squares that is identical with the pattern formed by the "template" squares. General, qualitative characteristics of the vortex–vortex interactions between objects of complex shapes are discussed. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1462607
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Bounds on Derivative Prices in an Intertemporal Setting with Proportional Transaction Costs and Multiple Securities (2001)
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Mathematical finance 11 (2001), S. 0 
    Details
    ISSN: 1467-9965
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mathematics , Economics
    Notes: The observed discrepancies of derivative prices from their theoretical, arbitrage-free values are examined in the presence of transaction costs. Analytic upper and lower bounds on the reservation write and purchase prices, respectively, are obtained when an investor's preferences exhibit constant relative risk aversion between zero and one. The economy consists of multiple primary securities with stationary returns, a constant rate of interest, and any number of American or European derivatives with, possibly, path-dependent arbitrary payoffs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1467-9965.00118
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    How the Emotional Climate (Field) Impacts Performance (2003)
    Oxford, UK and Malden, USA : Blackwell Publishing Ltd
    Creativity and innovation management 12 (2003), S. 0 
    Details
    ISSN: 1467-8691
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Independently of the creativity movement, others have demonstrated the benefits of creating positive fields. I have reviewed a number of cases involving field below and added some from my own creativity experiences. I then explore the psychological explanation of why such fields are effective and go on to the findings of recent brain research, which not only reinforce the benefits of positive fields but also throw light on the difficulty of creating them. Finally, I offer some suggestions from my own experience of what can be done to create positive fields. I believe that this should now be the focus of our efforts: to the extent that we are successful, we should get the creativity and innovation we need as a by-product.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0963-1690.2003.00287.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Predictive Power of Peer Behavioral Assessment for Subsequent Maladjustment in Community Samples of Disruptive and Nondisruptive Children (2000)
    Oxford, UK and Boston, USA : Blackwell Publishing Ltd.
    The @journal of child psychology and psychiatry 41 (2000), S. 0 
    Details
    ISSN: 1469-7610
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: In a prospective, longitudinal study with community samples of disruptive and nondisruptive children, the predictive relations between peer-assessed dimensions of behavioral reputation in elementary school and teacher-rated behavioral adjustment and test scores of academic achievement were examined over a 4-year period. The Revised Class Play (RCP), a social role matching instrument completed by students about their classmates, was used to assess behavioral dimensions of children's peer reputation at baseline. Regression analyses showed that the RCP dimensions of aggressive-disruptive, sensitive-isolated, and social etiquette were the best predictors of later teacher-rated externalizing problems, internalizing problems, and subsequent adaptive skills respectively. Only IQ predicted later academic achievement. When IQ and disruptive/nondisruptive group status were added to each regression equation they further contributed as significant predictors. When parent and teacher ratings of behavior problems at baseline were entered jointly with RCP dimensions into regression equations, the peer dimensions further explained outcome variance. Additive effects of the RCP dimensions were found only for the externalizing problems outcome. Disruptive children with mild levels of aggressive behavior and high levels of sensitive-isolated behavior had less externalizing problems at outcome. A comparison of the difference between disruptive and nondisruptive groups in the relationship of baseline RCP scores to teacher outcomes showed no difference between groups, suggesting that the groups did not depart appreciably from their initial differences relative to each other over time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1469-7610.00559
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    A Home-based Description of Attachment in Physically Disabled Infants (2002)
    Oxford, UK and Malden, USA : Blackwell Publishers Ltd.
    Social development 11 (2002), S. 0 
    Details
    ISSN: 1467-9507
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Notes: This study investigated attachment security and behavior in 34 physically disabled infants and 26 non-disabled infants by using convergent, categorical (secure, avoidant and ambivalent) and continuous (Attachment Behavior Q-Set) measures of the relationship, based on the same set of home observations. Proportions of attachment classifications were not different for disabled and non-disabled infants, but insecure infants in the disabled group scored consistently lower on the AQS security score than non-disabled insecure infants. This result suggests that while proportions of attachment classifications may not vary as a function of infant status, insecure disabled infants are more insecure than insecure non-disabled infants. An analysis of 5 behavioral dimensions of the AQS showed that secure infants emitted the same kinds of attachment behaviors without regard for infant status. Insecure disabled infants, however, showed lower levels of secure base behavior and physical contact with mother than their non-disabled counterparts, and showed a marginal tendency to fuss more as well. Discussion focuses on the potential benefits of using convergent, categorical and continuous measures of attachment in the study of both typical and atypical groups of infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1467-9507.00192
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    E-learning challenges in the Arab world: revelations from a case study profile (2004)
    Bingley : Emerald
    Quality assurance in education 12 (2004), S. 15-27 
    Details
    ISSN: 0968-4883
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Education
    Notes: The overwhelming traditional knowledge delivery system for higher education in the Arab world demonstrates the pronounced information technology (IT) gap between Arab countries and the developed world. This study demonstrates the problems and possibilities of implementing e-learning in Arab educational institutions through analysing the attitudes of university professors (n = 294) in Lebanon towards three a priori e-learning dimensions. Favourable attitudes towards e-learning attested to faculty members' interest to get engaged in a fully-fledged e-learning programme in a country where the primary delivery educational model is essentially traditional. Discusses these attitudes in the light of the social, political and economic hindrances that impede the implementation of e-learning in the Arab region. A series of K-independent Kruskal-Wallis tests yielded significant attitudinal variations between males and females as well as between computer daily users and occasional users. Furthermore, daily computer users documented more favourable attitudes towards e-learning than their occasional user counterparts. Offers recommendations for the implementation of e-learning in "traditionally" demarcated educational systems in countries where the deployment of information and communications technologies is not widespread.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09684880410517405
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Promoting services via the Internet: new opportunities and challenges (2002)
    Bradford : Emerald
    The @journal of services marketing 16 (2002), S. 412-423 
    Details
    ISSN: 0887-6045
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: The Internet has the potential to revolutionize all kinds of business activities, including the creation, promotion, and delivery of services. In this paper, we examine the intersection of two frameworks in order to identify new opportunities for delivering and promoting services via the Internet. The first framework is based on technology and network boundaries (e.g. intranet, extranet, Internet). The second framework is based on the business objective of the network application (e.g. automation, information, transformation). By combining these two frameworks, we identify nine new ways to create and promote services.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/08876040210436885
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Ab initio structure determination of the lantibiotic mersacidin (2000)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 56 (2000), S. 705-713 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The crystal structure of mersacidin, a potential novel antibiotic against methicillin- and vancomycin-resistant Staphylococcus aureus strains, has been determined by ab initio methods. Despite all crystals being merohedrally twinned, an accurate structural model with an R value of 13.4% has been obtained at atomic resolution. With six molecules in the asymmetric unit and no atom heavier than sulfur, the structure corresponds to a protein of 120 amino acids and is the largest approximately equal-atom unknown structure solved by direct methods. In the crystal, the molecule assumes a compact fold different from that found by NMR in solution. Comparison of the NCS-related molecules reveals regions of variable flexibility. The region highly homologous to the related antibiotic actagardine is very rigid and possibly defines an essential building block of this class of new antibacterial substances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444900003711
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...