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  • 2000-2004  (15)
  • 1
    Electronic Resource
    Electronic Resource
    Both apoptosis and necrosis occur early after intracerebral grafting of ventral mesencephalic tissue: a role for protease activation (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 86 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Neural transplantation is an experimental treatment for Parkinson's disease. Widespread clinical application of the grafting technique is hampered by a relatively poor survival (around 10%) of implanted embryonic dopamine neurones. Earlier animal studies have indicated that a large proportion of the grafted cells die during graft tissue preparation and within the first few days after intracerebral implantation. The present study was designed to reveal the prevalence of cell death in rat intrastriatal grafts at 90 min, 1, 3, 6 and 42 days after implantation. We examined apoptotic cell death using semi-thin and paraffin sections stained with methylene blue and an antibody against activated caspase 3, respectively. We identified abundant apoptotic cell death up to 3 days after transplantation. In addition, we studied calpain activation using an antibody specific for calpain-cleaved fodrin. We report a peak in calpain activity 90 min after grafting. Surprisingly, we did not observe any significant difference in the number of dopaminergic neurones over time. The present results imply that grafted cells may be victims of either an early necrotic or a later apoptotic cell death and that there is substantial cell death as early as 90 min after implantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2003.01931.x
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  • 2
    Electronic Resource
    Electronic Resource
    δ15N of zooplankton species in subarctic lakes in northern Sweden: effects of diet and trophic fractionation (2004)
    Oxford, UK : Blackwell Science Ltd
    Freshwater biology 49 (2004), S. 0 
    Details
    ISSN: 1365-2427
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: 1. To assess the use of stable nitrogen isotopes (δ15N) for reconstructing trophic relationships in planktonic food webs, crustacean zooplankton species and pelagic dissolved and particulate matter were analysed in 14 subarctic lakes in northern Sweden. The lakes are situated along an altitudinal gradient and show a substantial variation in nutrient content and energy mobilization by bacterioplankton and phytoplankton.2. The δ15N of dissolved and particulate matter was comparatively low, suggesting efficient N recycling and low losses of depleted N from the pelagic zone of these unproductive lakes.3. Copepods had a systematically higher δ15N than cladocerans, with an average difference of 3.1–4.9‰ within lakes, implying different trophic positions of the two groups. Comparisons of nitrogen pools and energy fluxes suggest that the low cladoceran δ15N was a result of feeding on bacteria.4. The difference in δ15N between copepods and cladocerans declined with decreasing bacterioplankton production among lakes, due either to increasing trophic isotope fractionation or decreasing relative importance of bacteria in the diet of cladocerans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2427.2004.01208.x
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of functional outcome after anterior cruciate ligament reconstruction resulting in low, normal and increased laxity (2002)
    Oxford, UK : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 12 (2002), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The aim of the study was to analyse and compare the results after arthroscopic anterior cruciate ligament (ACL) reconstruction using patellar tendon autografts in three groups of patients. The groups were determined by knee laxity as measured with the KT-1000 arthrometer at the follow-up two to five years after the reconstruction. Group A (n=15) had an anterior side-to-side laxity difference of 〈−3 mm (i.e. the reconstructed knee was less lax than the contralateral non-injured knee), Group B (n=376) had a difference of ≥−1, but ≤+2 mm and Group C (n=38) had a difference of ≥6 mm. All the patients had a normal contralateral knee. In Group A, 7/15 (47%) patients and, in Group B, 82/375 (22%) patients had an extension deficit of ≥5° (P=0.052). The corresponding values in terms of flexion deficit were 8/15 (53%) and 99/375 (26%) respectively (P=0.04) (one missing value in Group B). In Group C, 14/38 (37%) had an extension deficit (P=0.04; Group B vs Group C). Group C displayed worse results than Group B in terms of the Lysholm score and the one-leg-hop test (P=0.001 and P=0.011 respectively). The corresponding comparison between Group A and Group B revealed no significant differences. We conclude that a considerable number of patients showed persisting deficits in range of motion (ROM) after an ACL reconstruction. No major differences were found if they were analysed in subgroups with decreased, near normal or with increased knee laxity. The worst residual functional impairment, as measured with the Lysholm score and one-leg-hop test, was found in the group with increased knee laxity and most ROM deficits in the knees with decreased laxity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0838.2002.120109.x
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  • 4
    Electronic Resource
    Electronic Resource
    Eccentric overload training for patients with chronic Achilles tendon pain – a randomised controlled study with reliability testing of the evaluation methods (2001)
    Copenhagen : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 11 (2001), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The purpose was to examine the reliability of measurement techniques and evaluate the effect of a treatment protocol including eccentric overload for patients with chronic pain from the Achilles tendon. Thirty-two patients with proximal achillodynia (44 involved Achilles tendons) participated in tests for reliability measures. No significant differences and strong (r=0.56–0.72) or very strong (r=0.90–0.93) correlations were found between pre-tests, except for the documentation of pain at rest (P〈0.008, r=0.45). To evaluate the effect of a 12-week treatment protocol for patients with chronic proximal achillodynia (pain longer than three months) 40 patients (57 involved Achilles tendons) with a mean age of 45 years (range 19–77) were randomised into an experiment group (n=22) and a control group (n=18). Evaluations were performed after six weeks of treatment and after three and six months. The evaluations (including the pre-tests), performed by a physical therapist unaware of the group the patients belonged to, consisted of a questionnaire, a range of motion test, a jumping test, a toe-raise test, a pain on palpation test and pain evaluation during jumping, toe-raises and at rest. A follow-up was also performed after one year. There were no significant differences between groups at any of the evaluations, except that the experiment group jumped significantly lower than the control group at the six-week evaluation. There was, however, an overall better result for the experiment group with significant improvements in plantar flexion, and reduction in pain on palpation, number of patients having pain during walking, having periods when asymptomatic and having swollen Achilles tendon. The controls did not show such changes. Furthermore, at the one-year follow-up there were significantly more patients in the experiment group, compared with the control group, that were satisfied with their present physical activity level, considered themselves fully recovered, and had no pain during or after physical activity. The measurement techniques and the treatment protocol with eccentric overload used in the present study can be recommended for patients with chronic pain from the Achilles tendon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0838.2001.110402.x
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  • 5
    Electronic Resource
    Electronic Resource
    A prospective four- to seven-year follow-up after arthroscopic anterior cruciate ligament reconstruction (2001)
    Copenhagen : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 11 (2001), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The aim of this study was to evaluate the results after arthroscopic anterior cruciate ligament reconstruction using a bone-patellar tendon-bone graft in 99 patients, who were followed up prospectively for four to seven years. The pre-injury Tegner activity level was 7 compared with 5 at the four- to seven-year follow-up (P〈0.0001). The preoperative Lysholm score was 74.5 points. At the two-year follow-up, the Lysholm score was 95 points, while it was 90 points at the four- to seven-year follow-up (P〈0.0001 preoperative vs two years and preoperative vs four to seven years and P〈0.0005 two years vs four to seven years). Using the IKDC evaluation system, 80% of the patients were classified as normal or nearly normal and 20% as abnormal or severely abnormal at the final follow-up. The KT-1000 laxity measurements revealed a side-to-side difference of 2.9 mm preoperatively, 0.6 at two years and 1.0 mm at four to seven years. Twenty-six patients underwent additional surgery during the follow-up period. The results after arthroscopic reconstruction of the anterior cruciate ligament appear to be satisfactory both at the short- and the medium-term follow-ups, but there appears to be some deterioration between the two-year and the four- to seven-year follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0838.2001.011001023.x
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  • 6
    Electronic Resource
    Electronic Resource
    Iontophoresis with or without dexamethazone in the treatment of acute Achilles tendon pain (2003)
    Oxford, UK : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 13 (2003), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The purpose of this double-blind study was to evaluate the effects of iontophoresis with dexamethazone to iontophoresis with saline solution on patients who had acute (less than 3 months) pain from the Achilles tendon, in terms of range of motion, muscular endurance, pain and symptoms. Twenty-five patients (15 men and 10 women), aged between 18 and 76 years (mean = 38), were evaluated before and after 2 weeks of treatment with iontophoresis, as well as after 6 weeks, 3 and 6 months and 1 year. Two groups were treated for 2 weeks with iontophoresis for each treatment. Three ml of dexamethazone were used for the experiment group (n = 14) and 3 ml of saline solution for the control group (n = 11). Both groups then followed the same rehabilitation programme for 10 weeks. Good reliability was found for the toe-raise and range of motion tests. Poor reliability was, however, found for the pain on palpation test, which was therefore excluded. No difference was found between or within groups for the toe-raise test. Several significant improvements were seen in the experiment group but not in the control group, in the range of motion test, pain during and after physical activity, pain during walking and walking up and down stairs, morning stiffness and tendon swelling. Even though the small sample size limits the possibilities to draw definite conclusions, we conclude from the present study, using a double-blind, randomised approach and a 1-year follow-up period, that positive effects from using iontophoresis with dexamethazone were found in the treatment of patients with acute Achilles tendon pain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1600-0838.2003.00305.x
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  • 7
    Electronic Resource
    Electronic Resource
    Patellofemoral pain syndrome: pain, coping strategies and degree of well-being (2002)
    Oxford, UK : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 12 (2002), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The purpose of this study was to evaluate how patients with patellofemoral pain syndrome (PFPS) experience their pain, what coping strategies they use for the pain, and their degree of well-being. Fifty patients, 15–52 years old, with PFPS were evaluated with multidimensional pain inventory (MPI), coping strategies questionnaire (CSQ) and Spielberger state trait anxiety inventory (STAI). Reliability of the evaluation methods was established for 12 patients. Good reliability was established for all instruments except for six of the 13 scales of the MPI. Results on MPI, CSQ and STAI are in agreement with the literature on other patient groups with chronic pain. The most frequently used strategies were ‘coping self statements’ and ‘ignoring sensations’. High scores were found for the strategy ‘catastrophizing’ compared with other patient groups having chronic pain. The STAI scores were in general found to be somewhat higher than the scores found in the literature on healthy subjects. It is concluded that the way patients with PFPS experience their pain, the coping strategies for pain they use and their degree of well-being, are in agreement with other patient groups who have chronic pain. Some concern is raised in terms of the high scores reported for the coping strategy ‘catastrophizing’.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0838.2002.10226.x
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  • 8
    Electronic Resource
    Electronic Resource
    Calf muscle function after Achilles tendon rupture. (2002)
    Oxford, UK : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 12 (2002), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: In a prospective, randomised, multicentre study, 112 patients with Achilles tendon rupture (ATR) were allocated to surgical treatment (n=59), followed by early functional rehabilitation using a brace, and non-surgical treatment (n=53), i.e. eight weeks of plaster treatment. In this study, the results of the isokinetic muscle strength evaluation are presented for contractions in both the concentric and the eccentric mode, plantar flexion and dorsiflexion, two angular velocities and three different positions of the subject. The heel-raise test for endurance, maximum calf circumference and tendon width were also evaluated. The re-rupture rate was 20.8% in the non-surgically-treated group and 1.7% in the surgically-treated group. No significant differences were found between the treatment groups in terms of the isokinetic strength measurements and the endurance test among the patients who did not sustain a re-rupture. If a re-rupture is avoided, both surgical and non-surgical treatment for ATR produce good functional outcome; however, the muscle function was not restored after two years in either group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0838.2002.120103.x
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  • 9
    Electronic Resource
    Electronic Resource
    Hamstring injury occurrence in elite soccer players after preseason strength training with eccentric overload (2003)
    Oxford, UK : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 13 (2003), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The primary purpose of this study was to evaluate whether a preseason strength training programme for the hamstring muscle group – emphasising eccentric overloading – could affect the occurrence and severity of hamstring injuries during the subsequent competition season in elite male soccer players. Thirty players from two of the best premier-league division teams in Sweden were divided into two groups; one group received additional specific hamstring training, whereas the other did not. The extra training was performed 1–2 times a week for 10 weeks by using a special device aiming at specific eccentric overloading of the hamstrings. Isokinetic hamstring strength and maximal running speed were measured in both groups before and after the training period and all hamstring injuries were registered during the total observational period of 10 months. The results showed that the occurrence of hamstring strain injuries was clearly lower in the training group (3/15) than in the control group (10/15). In addition, there were significant increases in strength and speed in the training group. However, there were no obvious coupling between performance parameters and injury occurrence. These results indicate that addition of specific preseason strength training for the hamstrings – including eccentric overloading – would be beneficial for elite soccer players, both from an injury prevention and from performance enhancement point of view.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0838.2003.00312.x
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  • 10
    Electronic Resource
    Electronic Resource
    Functional outcome of anterior cruciate ligament reconstruction in recreational and competitive athletes (2001)
    Copenhagen : Munksgaard International Publishers
    Scandinavian journal of medicine & science in sports 11 (2001), S. 0 
    Details
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The aim of this study was to compare the outcome after anterior cruciate ligament reconstruction in recreational and competitive athletes, with a minimum follow-up of two years. Forty-nine patients (24 males and 25 females) who, at the time of the index injury, were classified as recreational athletes (Tegner level 2–5) were compared with 226 patients (61 females and 165 males) who, at the time of the index injury, were classified as competitive athletes (Tegner level 9–10). At the follow-up, no significant differences were found between the study groups in terms of the Lysholm score, IKDC evaluation system, one-leg-hop test, KT-1000 laxity measurements, anterior knee pain and the patients’ subjective evaluation of the results. However, the competitive athletes displayed a significantly higher reduction in Tegner activity level than the recreational athletes. The functional and objective results after anterior cruciate ligament reconstruction were comparable for the recreational and competitive athletes. We, therefore, conclude that anterior cruciate ligament reconstruction could be recommended for recreational athletes as well as competitive athletes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0838.2001.110605.x
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