ISSN:
1600-079X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
To examine the effect of melatonin on in vitro fertilization and embryonic development, mouse embryos after insemination in vitro were cultured in a physiological medium with or without melatonin. Melatonin increased the fertilization rate significantly at a concentration between 10−6 and 10−4 M (27.6 vs. 43.9 or 40.4%, P〈0.01). Furthermore, a significant increase in the rate of embryos reaching the four-cell stage (16.0 vs. 26.7%, P〈0.01), the eight-cell stage (12.1 vs. 25.8 or 23.5%, P〈0.01), and blastulation (8.9 vs. 23.5 or 17.5%, P〈0.01) was observed when the embryos were cultured in a medium containing 10−8 or 10−6 M melatonin. These results demonstrate that melatonin supports fertilization and early embryo development after in vitro fertilization.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1034/j.1600-079x.2000.280107.x
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