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  • 1
    Electronic Resource
    Electronic Resource
    The CRESST dark matter search (2000)
    Springer
    Physics of atomic nuclei 63 (2000), S. 1242-1248 
    Details
    ISSN: 1063-7788
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We discuss the short-and long-term perspectives of the CRESST (Cryogenic Rare Event Search using Superconducting Thermometers) project and present the current status of the experiment and new results concerning detector development. In the search for elementary particle dark matter, CRESST is presently the most advanced deep underground, low-background, cryogenic facility. The basic technique involved is to search for WIMPs (Weakly Interacting Massive Particles) by the measurement of nonthermal phonons, as created by WIMP-induced nuclear recoils. Combined with our newly developed method for the simultaneous measurement of scintillation light, strong background discrimination is possible, resulting in a substantial increase in WIMP detection sensitivity. This will allow a test of the reported positive evidence for a WIMP signal by the DAMA Collaboration in the near future. In the long term, the present CRESST setup permits the installation of a detector mass up to 100 kg. In contrast to other projects, CRESST technology allows the employment of a large variety of detection materials. This offers a powerful tool in establishing a WIMP signal and in investigating WIMP properties in the event of a positive signal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1134/1.855777
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Activity Increase After Extraction of Alkaline Phosphatase from Human Osteoblastic Membranes by Nonionic Detergents: Influence of Age and Sex (2000)
    Springer
    Calcified tissue international 66 (2000), S. 22-28 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Anchored alkaline phosphatase — Detergents — Bone cells — Age.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The solubilization of alkaline phosphatase (AP) from osteoblastic cell membranes obtained from human primary bone cell cultures was studied according to the age and sex of the donors (17 females, 11 males; age range: 2–77 years). Cell membranes were treated by non-ionic (n-octyl β-D-glucopyranoside, OG), ionic or zwitterionic detergents, then centrifuged. When OG was used almost all the AP was solubilized. AP activity in supernatant of solubilization was compared to the activity of the suspension before centrifugation. The activity ratio (AR) increased in function of age for subjects between 65 and 74. Neither total nor specific AP activities were influenced by age or sex. Electrophoresis studies showed that the AP released was a GPI (glycosyl phosphatidylinositol)-anchored protein, amphipatic form, with 140 kDa as apparent molecular mass. The activity change of AP in the presence of OG may result from age-related modifications either in the AP structure or in the constituents of the plasma membranes (proteins or phospholipids).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002230050006
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    Paper (German National Licenses)
    Fulltext
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