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Cryoprecipitate-removed plasma ‘cryo-removed plasma’ as a source of factor IX in the treatment of haemophilia B (2004)

Lepatan, L. M. P. ; Hernandez, F. G. ; Montoya, M. M. ; [et al.]

Oxford, UK : Blackwell Science Ltd

Haemophilia 10 (2004), S. 0

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ISSN: 1365-2516

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Summary. Fresh frozen plasma (FFP) is the main source of factor IX (FIX) in the treatment of bleeding episodes of haemophilia B in the Philippines. Cryoprecipitate-removed plasma otherwise known in the Philippines as cryosupernate, is a by-product of cryoprecipitate preparation. These blood products expire in storage or are just thrown- away because of less demand for clinical use. By theory, this product should have almost the same amount of FIX as in FFP, therefore can be used in the treatment of haemophilia B. There is no local data on the actual FIX content of the cryoprecipitate-removed plasma. Hence, the authors established these data to support the use of this product. Eighty-three bags of cryoprecipitate-removed plasma received from three different blood banks in Manila, Philippines were tested for FIX activity using an activated partial thromboplastin time (APTT)-based one-stage FIX assay. The FIX content in each bag of cryoprecipitate-removed plasma was calculated by multiplying its volume in mL with that of FIX activity per mL of plasma measured in vitro. The total mean FIX content per bag was 212.20 U (±88.98) exceeding the contents set by the American Association of Blood Banks (AABB, 70–90 U). The mean FIX activity per bag was 127.62% (±38.23) with the mean volume of 164.28 mL (±52.23). Statistically significant difference on volume (P = 0.000) was found across the three sources resulting to a significant variation of the actual FIX content (P = 0.000).

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2516.2004.00884.x

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Comparison of the last interglacial climate simulated by a coupled global model of intermediate complexity and an AOGCM (2000)

Kubatzki, C. ; Montoya, M. ; Rahmstorf, S. ; [et al.]

Springer

Climate dynamics 16 (2000), S. 799-814

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ISSN: 1432-0894

Source: Springer Online Journal Archives 1860-2000

Topics: Geosciences , Physics

Notes: Abstract The climate at the Last Interglacial Maximum (125 000 years before present) is investigated with the atmosphere-ocean general circulation model ECHAM-1/LSG and with the climate system model of intermediate complexity CLIMBER-2. Comparison of the results of the two models reveals broad agreement in most large-scale features, but also some discrepancies. The fast turnaround time of CLIMBER-2 permits one to perform a number of sensitivity experiments to (1) investigate the possible reasons for these differences, in particular the impact of different freshwater fluxes to the ocean, (2) analyze the sensitivity of the results to changes in the definition of the modern reference run concerning CO2 levels (preindustrial versus “present”), and (3) estimate the role of vegetation in the changed climate. Interactive vegetation turns out to be capable of modifying the initial climate signals significantly, leading especially to warmer winters in large parts of the Northern Hemisphere, as indicated by various paleodata. Differences due to changes in the atmospheric CO2 content and due to interactive vegetation are shown to be at least of the same order of magnitude as differences between the two completely different models, demonstrating the importance of careful experimental design.