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  • 1
    Electronic Resource
    Electronic Resource
    Plasma levels of opioid peptides after sunbed exposures (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background  Previous studies have indicated that solar and artificial ultraviolet (UV) radiation have a positive influence on psychological variables such as mood and emotional state. Circulating opioid peptides have been suggested as being important in this effect. Objectives  To investigate in a controlled trial the influence of UVA radiation on opioid peptide levels. Methods  We determined plasma levels of β-endorphin immunoreactive material (IRM) and met-enkephalin in UV-exposed ( n  = 35) and non-exposed ( n  = 9) healthy volunteers. On the first day of the study, blood samples were taken from the volunteers (time A). UVA irradiation was subsequently administered with an air-conditioned tanning device. During the UV exposures the volunteers wore opaque goggles. Twenty minutes after UV exposure, blood samples were collected again (time B). Within the following 3 weeks the volunteers had a series of five UV exposures. On the last day of the study (24 h after the sixth UV exposure) blood samples were collected (time C). The cumulative UVA doses were 96 J cm −2 for skin type II and 126 J cm −2 for skin type III. The controls had no UV exposures. Plasma β-endorphin IRM and met-enkephalin levels were determined using radioimmunoassays. Results  At all times of blood collection (A, B, C), there were no significant differences in plasma levels of β-endorphin IRM and met-enkephalin between UV-exposed and non-exposed volunteers ( P  〉 0·05). Conclusions  UVA irradiation does not significantly elevate plasma levels of β-endorphin IRM and met-enkephalin. Therefore we suggest that psychological benefits claimed to occur after UV exposure are unlikely to be mediated by the types of circulating opioid peptides measured in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04859.x
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  • 2
    Electronic Resource
    Electronic Resource
    Endotoxemia in organ donors: graft function following liver transplantation (2000)
    Springer
    Transplant international 13 (2000), S. S286 
    Details
    ISSN: 1432-2277
    Keywords: Key words Endotoxin ; Liver transplantation ; Graft function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Translocation of endotoxin (LPS) to the portal-venous system is produced by multiple factors. In the case of normal liver function, LPS is rapidly cleared from the portal blood by Kupffer cells; in impaired liver function, LPS can reach the systemic circulation. The objective of this study was to investigate whether elevated donor endotoxin levels affect graft function in the recipient. LPS levels in donor plasma were measured in 14 consecutive liver transplantations. Grafts with donor LPS levels ≤ 12 pg/ml had a function probability of 100 % after 600 days (n = 10). LPS concentrations of 〉 12 pg/ml in donor plasma led to loss of function in 75 % of the liver grafts (n = 4; P = 0.003; Wilcoxon). Elevated LPS values in donor plasma seem to impair the prognosis of the grafts and could predict poor graft function as early as at the time of brain death.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050343
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  • 3
    Electronic Resource
    Electronic Resource
    The quality of a liver graft (2000)
    Springer
    Transplant international 13 (2000), S. S288 
    Details
    ISSN: 1432-2277
    Keywords: Key words Liver graft quality ; Effluates ; Prediction of survival ; Glutathione S-transferase ; Glutamate dehydrogenase ; Leucocyte count
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Because transplantation success is influenced by the quality of the graft, the objective of this study was to find parameters to evaluate transplant livers in the recipient centre. In 64 liver grafts, the venous effluates of a portal back-table flush were investigated for various parameters. Amongst them, glutathione S-transferase (GST), glutamate dehydrogenase (GLDH) and the leucocyte count were found superior in predicting graft survival. Using the combination of these parameters, 100-day graft survival of between 95 % (all parameters positive) and 0 % (all parameters negative) was predicted. We concluded that good liver grafts are characterized by a low width of injury (cytosolic component: GST), a low depth of injury (mitochondrial component: GLDH), as well as by a potential to induce tolerance (passenger leucocytes). Perfusate analysis seems to be a valuable tool to recognize problematic grafts in advance and to quantify the “graft factor” in considerations concerning quality control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050344
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  • 4
    Electronic Resource
    Electronic Resource
    RANTES in the postoperative course after liver transplantation (2000)
    Springer
    Transplant international 13 (2000), S. S147 
    Details
    ISSN: 1432-2277
    Keywords: Key words RANTES ; Liver transplantations ; Graft survival ; Rejection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract RANTES (regulated upon activation, normal T-cell expressed and secreted), an inflammatory cytokine, promotes accumulation and activation of leukocytes. In 67 liver transplantations, systemic concentrations of RANTES were correlated to graft survival and incidence of rejection. RANTES levels either increased to highly elevated levels at day 14 (84 ± 64 ng/ml; group 1; n = 43) or remained within the limit of healthy controls (19 ± 11 ng/ml at day 14; group 2; n = 24). The 100-day graft function rate was 0.91 in group 1 and 0.63 in group 2 (P = 0.002). The risk ratio for rejection during the first 100 days was increased 2.2-fold in group 2 compared to group 1 (P = 0.02). High postoperative release of RANTES after liver transplantation, a beneficial factor, may reflect a general systemic immunological activation. It can be concluded that high early systemic RANTES levels may play a role in immunological recognition leading to a tolerance of the liver graft.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050307
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of perioperative sHLA I concentrations on the histological development of the liver graft (2000)
    Springer
    Transplant international 13 (2000), S. S449 
    Details
    ISSN: 1432-2277
    Keywords: Key words Soluble HLA I (sHLA) ; Flush catheter ; Rejection ; Liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Soluble HLA I (sHLA I) in human serum are ascribed an immunoregulatory role in the context of organ transplantation. Based on histological findings, the objective of the current study was to evaluate the protective influence of sHLA I in liver transplantation from the time point of reperfusion. The sHLA I concentrations in serum samples derived from the liver vein immediately after reperfusion (flush catheter) of 38 patients with liver transplantations were determined by ELISA. The postoperative histological findings of the transplant biopsies were categorized according to rejection, endothelialitis, cholestasis, and necrosis, as well as fatty degeneration. An evaluation according to Kaplan-Meier showed a lower incidence for all of these factors in liver grafts with high sHLA concentrations (P 〈 0.05). We conclude that low sHLA I concentrations during reperfusion correlate with later complications, thus indicating that sHLA I may have protective potential in liver transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050380
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    Paper (German National Licenses)
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