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  • 2000-2004  (4)
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Material
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Pruritus-associated response mediated by cutaneous histamine H3 receptors (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Histamine is one of the most common chemical mediators causing pruritus, and H1 receptor antagonists have been used as a first choice in its treatment. On the other hand, although the presence of H3 receptors has been identified in the skin, few studies have investigated the involvement of H3 receptors on pruritus.Objective  The purpose of this study was to examine whether H3 receptor agonist or antagonist influences the incidence of scratching behaviour in ICR or mast cell-deficient WBB6F1-W/WV mice.Methods  The mice were given an intradermal injection of H3 receptor agonist or antagonist into the rostral part of the back, and the occurrence of scratching behaviour at the injected site by the hind paws was counted over 60 min.Results  H3 receptor antagonists, thioperamide and AQ0145 significantly increased the incidence of scratching behaviour in ICR mice. H3 receptor agonist, (R)-alpha-methylhistamine, had no effect. On the other hand, (R)-alpha-methylhistamine significantly inhibited thioperamide or AQ0145-induced scratching behaviour. In addition, both thioperamide and AQ0145 elicited scratching behaviour in mast cell-deficient WBB6F1-W/WV mice.Conclusion  From these results, it may be concluded that H3 receptors are involved in the modulation of pruritus in the skin, and mast cells are not essential in this response. In addition, H3 receptor agonists can be useful as a novel therapeutic approach against pruritus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.01876.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Experimental verification of guided modes in 60°-bent defect waveguides in AlGaAs-based air-bridge-type two-dimensional photonic crystal slabs (2002)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 91 (2002), S. 3477-3479 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Sixty-degree-bent defect waveguides (DWGs) in an AlGaAs-based air-bridge-type two-dimensional photonic crystal (2D PC) slab were fabricated, and the resulting optical transmission spectra and the plan-view image of the optical beam propagating along the bent DWG were measured in the wavelength range between 850 and 1100 nm. Using the two output ports of the stripe waveguides, one aligned to and another offset from the output edge of the bent DWG, the guided mode specific to the DWG and the slab mode in the defect-free PC slab were experimentally observed with the same sample. These results were verified using the calculated band structure and transmission spectra. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1436554
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Theoretical and experimental investigation of straight defect waveguides in AlGaAs-based air-bridge-type two-dimensional photonic crystal slabs (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 79 (2001), S. 4286-4288 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A detailed investigation was undertaken from both theoretical and experimental perspectives of straight defect waveguides in an AlGaAs-based air-bridge-type two-dimensional photonic crystal slab. Optical propagation properties were obtained by two methods: measurement of transmission spectra at wavelengths ranging from 850 to 1100 nm, and with plan-view observations of the optical beam trace along the waveguide measured with an infrared-vidicon camera. Three-dimensional finite-difference time-domain simulations for the band structure and transmission spectra in the air-bridge slab with and without defect waveguides resulted in the appearance of defect propagation modes specific to the defect waveguide, between two slab modes for the defect-free photonic crystal slab. These defect modes were experimentally identified in the measured transmission spectra. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1427752
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  • 4
    Electronic Resource
    Electronic Resource
    Involvement of histamine H3 receptors in scratching behaviour in mast cell-deficient mice (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Although the roles of histamine H3 receptors have been studied in several tissues such as the brain, lung, spleen, colon and peripheral sensory nerve endings, the involvement of H3 receptors in skin responses particularly in relation to scratching behaviour are not well documented. Objectives This work was performed to study the effects of histamine H3 antagonists on scratching behaviour in mast cell-deficient mice. Methods Histamine H3 antagonists iodophenpropit and clobenpropit, histamine and substance P were injected intradermally into the rostral part of the back of mast cell-deficient (WBB6F1 W/Wv) and wild-type (WBB6F1+/+) mice and scratching behaviour was measured for 60 min. The effects of H1 antagonists on scratching behaviour induced by H3 antagonists were also investigated. Results Intradermal injection of iodophenpropit and clobenpropit at doses of 10 and 100 nmol per site caused significant increases in scratching behaviour in both mast cell-deficient and wild-type mice. Histamine also caused a dose-related increase in the incidence of scratching behaviour, and a significant effect was observed at a dose of 100 nmol per site in both mast cell-deficient and wild-type mice. Substance P was also effective in causing scratching behaviour in both mast cell-deficient and wild-type mice. However, histamine H1 antagonists diphenhydramine and chlorphenamine failed to inhibit H3 antagonist-induced scratching behaviour in both types of mice. Conclusions Our results indicated that intradermal injection of H3 antagonists induces scratching behaviour and that chemical mediators other than histamine seem to be involved in the response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05341.x
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    Paper (German National Licenses)
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