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  • 2000-2004  (3)
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Material
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Novel agonists for cold receptors on sensory neurons (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc
    Experimental dermatology 13 (2004), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An exciting research topic these past 2 years has been the identification of transient receptor potential (TRP) channel protein receptors on sensory neurons that are linked to thermosensation. Two compounds, menthol and icilin, were shown to activate the putative cold receptor, TRP-M8 (CMR1, trp-p8), in vitro. Here, some of the pharmacological properties of icilin are described and compared to menthol, summarized in the table below.〈table frame="topbot"〉〈tgroup cols="1" align="left"〉〈colspec colnum="1" colname="col1" align="char" char="."/〉〈tbody valign="top"〉Menthol Stimulates TRP-M8 receptor, does not require extracellular  calcium for activity, and does not stimulate the ANKTM1 receptor. Mint odor Irritant and harsh taste at high concentrations Duration of action less than15 min after topical application After systemic administration, lethal at high concentrations  due to anesthetic activityIcilin Stimulates TRP-M8 and ANKTM1 receptor and requires  extracellular calcium for activity No odor No irritant activity on skin or mucous membranes Action on inflamed skin and mucous membranes (e.g.  eyelids, lips, nasal, and anorectal) can last 4–8 h〈row rowsep="1"〉 No anesthetic activity, and no lethality at doses of up to  1.5 g/kg intraperitoneally, but after systemic administration produces ‘wet dog shakes’ which are rapid, alternating contractions, and relaxations of the supination and pronation muscles about the spinal axis
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2004.0212am.x
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    CRH peptides modulate human hair follicle growth in vitro– a preliminary study (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc
    Experimental dermatology 13 (2004), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Mammalian skin may contain an equivalent of the hypothalamic-pituitary-adrenal axis (HPA), composed of locally produced corticotropin-releasing hormone (CRH) that, together with signalling via CRH receptor 1 (CRH-R1) and CRH-R2, may regulate local homeostasis. Studies in murine skin have demonstrated significant hair cycle-dependent fluctuations in the expression of CRH and urocortin peptides and CRH-Rs genes, suggesting a modulatory role for this signalling system in hair growth/cycling. This study was designed to investigate the effects of ligands showing increased selectivity for CRH-R1 [(D-Glu20)-CRH (10−7 and 10−8 m)] and CRH-R2 [(D-Pro5)-CRH (10−8 and 10−9 m)] and (D-Pro4)-urocortin (10−7 and 10−8 m) on human hair growth in ex vivo culture. (D-Pro5)-CRH can also activate CRH-R1, while (D-Pro4)-urocortin is highly selective for CRH-R2. Anagen hair follicles (HFs) were isolated from human scalp and stimulated for 9 days, with 10 HFs tested per CRH peptide concentration. Preliminary findings indicate that (D-Pro4)-urocortin (10−8 m) stimulated a 79% mean hair fibre elongation compared to the initial HF length over the 9-day study period. (D-Glu20)-CRH (10−8 m) also stimulated hair fibre elongation of 63% of initial length, while (D-Pro5)-CRH (10−9 m), which inhibited hair fibre elongation, compared to unstimulated controls. In agreement with our previous detection of CRH-R1 and CRH-R2 in human HFs, the above data suggest the existence of a functionally active CRH peptide/receptor system in cultured human HFs and suggest that signalling via these receptors may participate in the regulation of human hair growth/cycling in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2004.212bi.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    CRH peptides modulate proliferation, melanogenesis and dendri-city in human follicular melanocytes (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc
    Experimental dermatology 13 (2004), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Corticotropin-releasing hormone (CRH) is the most proximal element of the hypothalamic-pituitary-adrenal axis (HPA) and is the chief regulator of pituitary POMC gene expression and the subsequent production and secretion of POMC peptides. Previously, our laboratories documented cutaneous expression of CRH, urocortin and functional CRH receptors (CRH-Rs), suggesting their role in skin physiology and pathology. Human skin predominately expressed CRH-R1 with CRH-R2 being expressed primarily in the adnexal structures. While CRH-R activity has been implicated in the regulation of epidermal cell function, a role for these receptors in human hair biology has not yet been demonstrated. This study was designed to investigate the effects of modified CRH peptides (D-Glu20)-CRH, (D-Pro5)-CRH and (D-Pro4)-urocortin with respective selectivity for CRH-R1 and CRH-R2 on behaviour of cultured hair follicle melanocytes (HFMs) derived from scalp of seven normal individuals. HFMs were stimulated with these peptides (10−7−10−10 m) for 72 h. (D-Glu20)-CRH (10−8 m) and (D-Pro5)-CRH (10−9 and 10−10 m) markedly increased cell dendricity, melanogenesis and proliferation (P 〈 0.01) compared with unstimulated levels. While (D-Pro4)-urocortin failed to stimulate cell dendricity, this peptide did stimulate melanogenesis (10−8 m) (P 〈 0.01) and exhibited a biphasic proliferative response; stimulating pigment cell division at 10−7 and 10−8 m (P 〈 0.01) but inhibiting proliferation at 10−9 and 10−10 m (P 〈 0.01). Here, we demonstrate the existence of functionally active CRH-Rs in cultured human scalp HFM and show that signalling via these receptors modulates follicular melanocyte dendricity, melanogenesis and proliferation. Thus, activation of CRH-Rs may have a pivotal role in the regulation of follicular melanocyte homeostasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2004.212bh.x
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    Paper (German National Licenses)
    Fulltext
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