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Low-emittance electron-beam generation with laser pulse shaping in photocathode radio-frequency gun (2002)

Yang, J. ; Sakai, F. ; Yanagida, T. ; [et al.]

[S.l.] : American Institute of Physics (AIP)

Journal of Applied Physics 92 (2002), S. 1608-1612

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ISSN: 1089-7550

Source: AIP Digital Archive

Topics: Physics

Notes: A technique of laser-pulse shaping was developed for low-emittance electron-beam generation in a photocathode radio-frequency (rf) gun. The emittance growth due to space charge and rf effects in the rf gun was experimentally investigated with square and gaussian temporal pulse shapes. It was found that the square pulse shaping was a useful tool for both the reduction of nonlinear space-charge force and the correction of linear space charge. The normalized transverse rms emittance at 1 nC was obtained to be 1.20 πmm-mrad for the square pulse shape with pulse length of 9 ps full width at half maximum. The emittance was measured as a function of the electron bunch charge and the laser-pulse length. © 2002 American Institute of Physics.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1063/1.1487457

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Bone marrow CD34+ progenitor cells from rheumatoid arthritis patients support spontaneous transformation of peripheral blood B cells from healthy individuals (2000)

Hirohata, S. ; Yanagida, T. ; Nakamura, H. ; [et al.]

Springer

Rheumatology international 19 (2000), S. 153-159

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ISSN: 1437-160X

Keywords: Key words Epstein-Barr virus ; GM-CSF ; Rheumatoid arthritis ; Bone marrow ; B cell activation

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We show that bone marrow (BM) CD34+ progenitor cells from rheumatoid arthritis (RA) patients have the capacity to support spontaneous transformation of peripheral blood B cells. CD34+ cells purified from BM blood from eight RA patients and eight osteoarthritis (OA) patients were expanded with granulocyte/macrophage colony stimulating factor (GM-CSF) for 4–6 weeks. GM-CSF-stimulated BM CD34+ cells from three of eight RA patients, but none from seven OA patients, gave rise to spontaneous transformation of highly purified B cells of Epstein-Barr virus (EBV)- seronegative healthy donors. GM-CSF-stimulated BM CD34+ cells from four of six RA patients and from one of four OA patients also supported the spontaneous transformation of peripheral blood B cells from EBV-seropositive healthy donors. All the transformed B cell lines were positive for EBV-DNA as determined by PCR. Neither GM-CSF-stimulated BM CD34+ cells alone nor highly purified B cells alone gave rise to spontaneously transformed B cell lines. These results suggest that the capacity of BM CD34+ cells to support survival of B cells might contribute to the pathogenesis of RA by sustaining abnormal B cell responses.